Results 1 to 10 of about 94,537 (200)

Clinical Characteristics and Prognosis of Acute Myeloid Leukemia Patients with Protein Tyrosine Phosphatase Non-Receptor Type 11 Gene Mutation [PDF]

Pharmacogenomics and Personalized Medicine, 2023
Rui Huang,* Yi-Ting Zhang,* Yu Lin, Ru-Li Pang, Zhi Yang, Wei-Hua Zhao Department of Hematology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China*These ...
Huang R, Zhang YT, Lin Y, Pang RL, Yang Z, Zhao WH   +5 more
doaj   +5 more sources

Mometasone Furoate Inhibits the Progression of Head and Neck Squamous Cell Carcinoma via Regulating Protein Tyrosine Phosphatase Non-Receptor Type 11 [PDF]

Biomedicines, 2023
Mometasone furoate (MF) is a kind of glucocorticoid with extensive pharmacological actions, including inhibiting tumor progression; however, the role of MF in head and neck squamous cell carcinoma (HNSCC) is still unclear.
Lin Qiu, Qian Gao, Anqi Tao, Jiuhui Jiang, Cuiying Li   +4 more
doaj   +4 more sources

SHP2: A Redox-Sensitive Regulator Linking Immune Checkpoint Inhibitor Therapy to Cancer Treatment and Vascular Risk [PDF]

Antioxidants
Src homology 2-domain containing protein tyrosine phosphatase 2 (SHP2), encoded by the Ptpn11 gene (Tyrosine-protein phosphatase non-receptor type 11), is a key downstream effector of PD-1/PD-L1 signaling and is likely important, in addition to immune ...
Silvia Fernanda López Moreno, Stefania Assunto Lenz, Bernardo Casso-Chapa, Angelica Paniagua-Bojorges, Jung Hyun Kim, Nicolas L. Palaskas, Kevin T. Nead, Venkata S. K. Samanthapudi, Gilbert Mejia, Oanh Hoang, Jonghae Lee, Steven H. Lin, Joerg Herrmann, Guangyu Wang, Syed Wamique Yusuf, Cezar A. Iliescu, Noah I. Beinart, Charlotte Manisty, Masuko Ushio-Fukai, Tohru Fukai, Pietro Ameri, Roza I. Nurieva, Michelle A. T. Hildebrandt, Keri Schadler, Efstratios Koutroumpakis, Sivareddy Kotla, Nhat-Tu Le, Jun-ichi Abe   +27 more
doaj   +2 more sources

PTPN11 (protein tyrosine phosphatase, non-receptor type, 11) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on PTPN11 (protein tyrosine phosphatase, non-receptor type, 11), with data on DNA, on the protein encoded, and where the gene is implicated.
M Tartaglia, BD Gelb
openaire   +1 more source

A novel stop-gain pathogenic variant in FLT4 and a nonsynonymous pathogenic variant in PTPN11 associated with congenital heart defects

European Journal of Medical Research, 2022
Background Congenital heart defects (CHDs) are the most common congenital malformations, including structural malformations in the heart and great vessels.
Avisa Tabib, Taravat Talebi, Serwa Ghasemi, Maryam Pourirahim, Niloofar Naderi, Majid Maleki, Samira Kalayinia   +6 more
doaj   +1 more source

Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus

Frontiers in Immunology, 2020
Circular RNAs (circRNAs) constitute a class of covalently circular non-coding RNA molecules formed by 5′ and 3′ end back-splicing. The rapid development of bioinformatics and large-scale sequencing has led to the identification of functional circRNAs ...
Lan Yang, Lan Yang, Xiao Han, Xiao Han, Caiyan Zhang, Caiyan Zhang, Chengjun Sun, Saihua Huang, Saihua Huang, Wenfeng Xiao, Wenfeng Xiao, Yajing Gao, Yajing Gao, Qiuyan Liang, Qiuyan Liang, Feihong Luo, Wei Lu, Jinrong Fu, Yufeng Zhou, Yufeng Zhou   +19 more
doaj   +1 more source

Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice

Redox Biology, 2022
Objective: Inflammation and oxidative stress contribute to the progression of sepsis-induced acute lung injury (ALI). SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1) is a signaling adaptor protein, and mainly regulates inflammatory ...
Wanli Jiang, Chengtai Ma, Jiawei Bai, Xianjin Du   +3 more
doaj   +1 more source

Long-term GH treatment improves adult height in children with Noonan syndrome with and without mutations in protein tyrosine phosphatase, non-receptor-type 11 [PDF]

European Journal of Endocrinology, 2008
ContextNoonan syndrome (NS) is characterized by short stature, typical facial dysmorphology and congenital heart defects. Short-term effect of GH therapy in NS is beneficial, reports on the effect on adult height are scarce.ObjectiveTo determine the effect of long-term GH therapy in children with NS.DesignTwenty-nine children with NS were treated with ...
Noordam, C., Peer, Pg, Francois, I., De Schepper, Jean, Van Den Burgt, I., Otten, Bj   +5 more
openaire   +4 more sources

Sprouty-related Ena/Vasodilator-stimulated Phosphoprotein Homology 1-Domain-containing Protein (SPRED1), a Tyrosine-Protein Phosphatase Non-receptor Type 11 (SHP2) Substrate in the Ras/Extracellular Signal-regulated Kinase (ERK) Pathway [PDF]

Journal of Biological Chemistry, 2011
SHP2 is a tyrosine phosphatase involved in the activation of the Ras/ERK signaling pathway downstream of a number of receptor tyrosine kinases. One of the proposed mechanisms involving SHP2 in this context is to dephosphorylate and inactivate inhibitors of the Ras/ERK pathway.
Martina, Quintanar-Audelo, Permeen, Yusoff, Saravanan, Sinniah, Sumana, Chandramouli, Graeme R, Guy   +4 more
openaire   +2 more sources

Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage

Virulence, 2021
Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death are
Usama Ashraf, Zhen Ding, Shunzhou Deng, Jing Ye, Shengbo Cao, Zheng Chen   +5 more
doaj   +1 more source