Results 101 to 110 of about 94,537 (200)

Identification and Discrimination of Sulfated and Unsulfated Gut‐Hormone Biomarkers in Human Serum by Nanopore

Small, EarlyView.
This study discriminates between sulfated and unsulfated cholecystokinin‐8 gut‐hormone forms at single‐molecule‐level resolution. Using an aerolysin nanopore embedded in a hybrid lipid‐polymer membrane, the system produces distinct electrical signatures enabling highly sensitive detection, even in 20% human serum.
Luca Iesu, Laurent Bacri, Juan Pelta, Benjamin Cressiot   +3 more
wiley   +1 more source

Probing 3-Amino-2H-Azaindazoles as Allosteric Inhibitors of the Protein Tyrosine Phosphatase SHP2. [PDF]

ChemMedChem
Amoussa M, Efrém NL, Li F, Guo Z, Roske Y, Frank KJ, Pach S, Wolf CA, Bo F, Lesina M, Kintzel M, Alsalim R, Zeitz V, Csorba N, Radetzki S, Keserű GM, Daumke O, Algül H, Wolber G, Li J, Nazaré M.   +20 more
europepmc   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Genetic role in autoimmune encephalitis and paraneoplastic neurological syndromes. [PDF]

Curr Opin Neurol
Binks SNM, Yip J, Knight JC.
europepmc   +1 more source

Topic classification of synchrotron experiment proposals using the OpenAlex model: enhancing metadata granularity and assessing live service feasibility

Journal of Synchrotron Radiation, EarlyView.
This paper validates the OpenAlex model for real‐time topic classification of synchrotron proposals. The proposed live service architecture incorporates user verification, providing a scalable solution for introducing enhanced topic metadata into scientific workflows without sacrificing precision.Experiment proposals at synchrotron facilities serve as ...
Terence Tan, Oliver J. Clark, Matthew J. Derry, Renaud Duyme, Guilherme Abreu Faria, Robert Farla, Ralf Flaig, Yogal Prasad Ghimirey, Anushka Ghosh, Miguel A. Gomez-Gonzalez, Ellen L. Heeley, Anna Herlihy, Annette Kleppe, Paul Millar, Melanie Nentwich, Josh Pickston, Nick Terrill, Armin Wagner, Andrew C. Walters, Matthew Watson, Philippe Rocca-Serra, Susanna-Assunta Sansone, Stephen P. Collins   +22 more
wiley   +1 more source

Targeting MCL-1 and MAPK overcomes venetoclax resistance in FLT3-ITD-positive AML cells harbouring activating PTPN11 (SHP-2) mutations. [PDF]

Br J Haematol
Fleischmann M, Hansen O, Voigtländer D, Bechwar J, Schwietzer LJ, Bahr S, Schnetzke U, Fischer M, Heidel FH, Schnöder TM, Müller JP, Hochhaus A, Scholl S.   +12 more
europepmc   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

The dual-specificity phosphatase JSP1 regulates neutrophil adhesion via integrin-SRC signaling in vascular inflammation. [PDF]

J Biol Chem
Li L, Tonks NK.
europepmc   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

The tumor suppressor NDRG2 recruits protein phosphatase 2A to suppress STAT5 phosphorylation in adult T-cell leukemia/lymphoma. [PDF]

J Biol Chem
Ichikawa T, Nakahata S, Shimoda K, Murakami T, Morishita K.   +4 more
europepmc   +1 more source