Results 131 to 140 of about 94,537 (200)

Integrated Engineering of CAR‐T Cells for Solid Tumours

Cell Proliferation, EarlyView.
Solid tumours pose multifactorial barriers including antigen heterogeneity, immunosuppressive microenvironment, and poor T‐cell trafficking, limiting CAR‐T efficacy compared to hematologic malignancies. Integrated engineering strategies are essential, combining logic‐gated receptors for precision, metabolic‐epigenetic reprogramming for resilience, and ...
Chao Yang, Tan Li, Ping He, Zhijie Zhao, Shenglong Li, Liming Wang   +5 more
wiley   +1 more source

Unresolved mechanisms: a hypothesized spatial regulation of myosin light chain phosphorylation within the walls of resistance arteries. [PDF]

Front Physiol
Sun Z, Hill MA.
europepmc   +1 more source

CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems

The FEBS Journal, EarlyView.
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén, Viktória Varga, Fatime Szalai, Risa Miyaura, Nóra Förhécz, Bálint Csikós, Rebeka Gelencsér, Zsófia Gábriel, Timea Komlódi, Katalin Dezső, Ildikó Krencz, Dorottya Moldvai   +11 more
wiley   +1 more source

Mapping the SHP2 Allosteric Pocket With Target-Biased Covalent Fragments. [PDF]

Chembiochem
Efrém NL, Csorba N, Amoussa M, Ábrányi-Balogh P, Guo Z, Petri L, Bo F, Di Lorenzo V, Roske Y, Szalai TV, Mihalovits L, Simon J, Li J, Daumke O, Keserű GM, Nazaré M.   +15 more
europepmc   +1 more source

Hippo pathway disruption and YAP1 activation in anogenital papillary squamous intraepithelial lesion

Histopathology, EarlyView.
Disruption of the Hippo Pathway with YAP1 activation is a consistent finding in papillary squamous intraepithelial lesions and may underlie their altered epithelial maturation and HPV E6/E7 expression patterns, providing new insight into the pathogenesis of this distinct low‐risk HPV‐associated lesion.
Gloria Zhang, Karen L. Talia, W. Glenn McCluggage, Robert A. Soslow, Bin Yang   +4 more
wiley   +1 more source

Protein Tyrosine Phosphatases in Schizophrenia: A Review of Pathophysiology and Emerging Evidence. [PDF]

Cureus
Murugesan K, Rebellow D, Kasagga A, Mon AM, Anwar S.   +4 more
europepmc   +1 more source

Northern cod (Gadus morhua) movement: insights from acoustic telemetry and genomics

Journal of Fish Biology, EarlyView.
Abstract Knowledge of the timing and diversity of fish movements within a commercially exploited stock complex is required to ensure the sustainability of fisheries. Although migration can be driven by environmental factors, genomic mechanisms also play an important role in this complex life‐history trait. The northern cod (Gadus morhua) stock complex,
M. Lisette Delgado, Nicole Smith, Frederick Whoriskey, Steve Devitt, Emilie Novaczek, Corey J. Morris, Tony Kess, Ian Bradbury, Sara Iverson, Paul Bentzen, Daniel E. Ruzzante   +10 more
wiley   +1 more source

Major clinical improvement in a boy with developmental disabilities and a PTPN4 mutation with intensive re-education and an enriched environment in a day care hospital: a case report. [PDF]

J Med Case Rep
Tasu C, Oppetit A, Galbert C, Ouaki S, Zammouri I, Gazzano O, Mourao J, Mignot C, Cohen D, Benarous X.   +9 more
europepmc   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

DUSP family phosphatases in cell signaling, inflammation, and chronic diseases. [PDF]

J Biomed Sci
Wang CW, Chuang HC, Tan TH.
europepmc   +1 more source