Results 201 to 210 of about 278,188 (259)

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Proteomic profiling in personalized nutrition: a systematic review and methodological frameworks of randomized controlled trials. [PDF]

Front Nutr
Marino M, Tura S, Rendine M, Martini D, Del Bo' C, Riso P.   +5 more
europepmc   +1 more source

Current Standards and Perspectives in Proteomics for Cardiac Amyloidosis. [PDF]

Anal Chem
Greco F, McPhail E, Canetti D, Masri A, Ferrari Chen YF, Menichetti L, Aimo A, Franzini M, Ciccone L, Pucci A, Castiglione V, Limongelli G, Merlo M, Sinagra G, Basso C, Fontana M, Gillmore JD, McDonnell LA, Emdin M, Merlini G, Vergaro G.   +20 more
europepmc   +1 more source

The good, the bad, and the ugly: opportunities, challenges, and pitfalls in spatial proteomics modeling. [PDF]

Brief Bioinform
Haque SY, Shatabda S, Islam S, Dipu SA, Azim R.   +4 more
europepmc   +1 more source

Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells. [PDF]

Adipocyte
Al-Sayegh M, Khalili M, Alzaabi M, Sultana M, Ali L, Ali M, El-Hadidi M.   +6 more
europepmc   +1 more source

Correction to 'Integrating transcriptomics and proteomics to assess antisense oligonucleotide safety and efficacy: a time-resolved approach'. [PDF]

NAR Mol Med
europepmc   +1 more source