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A model for random sampling and estimation of relative protein abundance in shotgun proteomics.
Analytical Chemistry, 2004Proteomic analysis of complex protein mixtures using proteolytic digestion and liquid chromatography in combination with tandem mass spectrometry is a standard approach in biological studies.
Hongbin Liu, R. Sadygov, J. Yates
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Proteomics methods for subcellular proteome analysis
The FEBS Journal, 2013The elucidation of the subcellular distribution of proteins under different conditions is a major challenge in cell biology. This challenge is further complicated by the multicompartmental and dynamic nature of protein localization. To address this issue, quantitative proteomics workflows have been developed to reliably identify the protein complement ...
Romain Drissi +2 more
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Chemical proteomics for subcellular proteome analysis
Current Opinion in Chemical Biology, 2019Protein functions are tightly regulated by their subcellular localization and dynamic alteration. Chemical proteomics offers convenience and efficiency for profiling protein features in a native context. In this review, we summarize the recent progress of subcellular-compartment-focused chemical proteomics which do not rely on organelle fractionation ...
Hao Zhu, Tomonori Tamura, Itaru Hamachi
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The emerging role of mass spectrometry-based proteomics in drug discovery
Nature reviews. Drug discovery, 2022F. Meissner +3 more
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2007
Proteomics has been widely applied to several biomedical fields in recent years. The high-throughput capability of proteomics allows simultaneous examination of numerous proteins and offers the possibility of a global analysis of proteins in cells, tissues or biofluids.
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Proteomics has been widely applied to several biomedical fields in recent years. The high-throughput capability of proteomics allows simultaneous examination of numerous proteins and offers the possibility of a global analysis of proteins in cells, tissues or biofluids.
openaire +2 more sources
The MaxQuant computational platform for mass spectrometry-based shotgun proteomics
Nature Protocols, 2016Stefka Tyanova +2 more
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Single-pot, solid-phase-enhanced sample preparation for proteomics experiments
Nature Protocols, 2018Christopher S. Hughes +5 more
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Spatial proteomics: a powerful discovery tool for cell biology
Nature reviews. Molecular cell biology, 2019E. Lundberg, Georg H. H. Borner
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