Results 311 to 320 of about 218,532 (388)

Copper Overload Affects α‐Synuclein Clearance Mechanisms in a Parkinson's Disease In Vitro Model

open access: yesAdvanced Biology, Volume 10, Issue 5, May 2026.
This study reveals that copper overload disrupts neuronal protein clearance, leading to the accumulation of α‐synuclein and its phosphorylated form (p‐S129). By blocking autophagy and impairing the ubiquitin–proteasome system, copper promotes toxic aggregation in dopaminergic cells.
Debora Musarò   +4 more
wiley   +1 more source

Commissioning and clinical implementation of Monaco treatment planning system on a compact pencil beam scanning proton therapy system. [PDF]

open access: yesJ Appl Clin Med Phys
Xu X   +13 more
europepmc   +1 more source

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

open access: yesAdvanced Science, Volume 13, Issue 25, 4 May 2026.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng   +19 more
wiley   +1 more source

Challenges in Diagnosing and Treating Percutaneous Nephrostomy‐Related Urinary Tract Infection in Cancer Patients: A Retrospective Cohort Study

open access: yesCancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Objective We aimed to evaluate medical decisions regarding urinary tract infection (UTI), describe associated microorganisms, and assess potential risk factors for percutaneous nephrostomy‐related UTI (UTI‐PN). Methods Oncological patients who underwent percutaneous nephrostomy (PN) were included. We assessed percutaneous nephrostomy procedure‐
Jeferson Rodrigo Zanon   +3 more
wiley   +1 more source

B‐Lymphoblastic Leukemia With Isolated Central Nervous System Relapse Mimicking a Vestibular Schwannoma

open access: yesClinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT The central nervous system (CNS) is the most common site of extramedullary relapse in acute lymphoblastic leukemia (ALL). However, the diagnosis may be challenging due to its protean manifestations. A 64‐year‐old male reported right‐sided hearing loss with intermittent bilateral occipitotemporal headaches during a clinic follow‐up for Ph + B ...
Jun Yen Ng   +3 more
wiley   +1 more source

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