Results 211 to 220 of about 35,987 (237)

Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogene activation and perturbation of mitochondrial metabolism. [PDF]

J Biol Chem
Suspène R, Raymond KA, Guardado-Calvo P, Dairou J, Bonhomme F, Bonenfant C, Guyetant S, Lecomte T, Pagès JC, Vartanian JP.   +9 more
europepmc   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Proto-oncogene DEK binds to pre-mRNAs and regulates the alternative splicing of Hippo signaling genes in HeLa cells. [PDF]

Mol Genet Genomics
Liu D, Sun W, Han J, Wang C, Chen D, Wu Y, Chang Y, Yang B.   +7 more
europepmc   +1 more source

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway

Advanced Science, EarlyView.
Relapsed and refractory multiple myeloma remains a major clinical challenge. This study shows that FOXM1 contributes to resistance against BH3 mimetics in multiple myeloma cells. The FOXM1 inhibitor NB73 enhances the effectiveness of BH3 mimetics by reducing FOXM1 expression and suppressing the MYC pathway.
Zhi Wen, Yidan Wang, Kathryn C. Fox, Adam M. Bissonnette, Luke F. Moat, Terrie E. Kitchner, Kelsey Springstroh, Sung Hoon Kim, Dagna S. Sheerar, Patcharon Tanawattanacharoen, Chady A. Leon, Seth O. Fagbemi, John A. Katzenellenbogen, Scott J. Hebbring, Benita S. Katzenellenbogen, Siegfried Janz, Adedayo A. Onitilo   +16 more
wiley   +1 more source

Salicylate-Elicited Activation of AMP-Activated Protein Kinase Directly Triggers Degradation of C-Myc in Colorectal Cancer Cells. [PDF]

Cells
Matos ALSA, Ovens AJ, Jakobsen E, Iglesias-Gato D, Bech JM, Friis S, Bak LK, Madsen GI, Oakhill JS, Puustinen P, Moreira JMA.   +10 more
europepmc   +1 more source

Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy

Aggregate, EarlyView.
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang, Hao Fu, Jiangtao Lin, Meng Zhao, Chuanrong Chen, Hongze Liao, Yourong Duan   +6 more
wiley   +1 more source

Screening, Analysis, and Validation of Endoplasmic Reticulum Stress-Related DEGs in Epilepsy. [PDF]

Cell Mol Neurobiol
Shi S, Feng X, Cao Z, Wang L, Sun M, Zhao Z, Sun W.   +6 more
europepmc   +1 more source

Unlocking the Genetic Secrets of Acromegaly: Exploring the Role of Genetics in a Rare Disorder. [PDF]

Curr Issues Mol Biol
Balinisteanu I, Caba L, Florea A, Popescu R, Florea L, Ungureanu MC, Leustean L, Gorduza EV, Preda C.   +8 more
europepmc   +1 more source

Reverse Vaccinology and Immunoinformatics Strategy to Screen Oncogenic Proteins and Development of a Multiepitope Peptide Vaccine Targeting Protein Kinases against Oral Cancer: An in-silico Study. [PDF]

Asian Pac J Cancer Prev
Shaikh S, Kunchala D, Patel M, Velecha D, Prajapati S, Gupta R.   +5 more
europepmc   +1 more source

Recent updates in pediatric diffuse glioma classification: insights and conclusions from the WHO 5^th edition. [PDF]

J Med Life
Patel T, Singh G, Goswami P.
europepmc   +1 more source