Results 121 to 130 of about 260,711 (183)

Unraveling the Impact of KRAS Accessory Proteins on Oncogenic Signaling Pathways. [PDF]

Cells
Garg V, Hofmann RNHM, Saleem M, Mirzaiebadizi A, Hashemi GS, Hameed T, Jooyeh B, Pudewell S, Mehrabipour M, Mosaddeghzadeh N, Piekorz RP, Ahmadian MR.   +11 more
europepmc   +1 more source

A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Atractylone exhibits diverse pharmacological effects, including anticancer and neuroprotection. A systematic review was conducted following PRISMA guidelines to analyze Atractylone. This study explores Atractylone's sources, biosynthesis, and therapeutic potential.
Hamza Elhrech, Oumayma Aguerd, Meriem El Fessikh, Zouhair Essahli, Taoufiq Benali, Waleed Al Abdulmonem, Learn‐Han Lee, Imane Chamkhi, Abdelhakim Bouyahya   +8 more
wiley   +1 more source

Network centric identification of PI3K/Akt hub proteins as key oncogenic drivers and therapeutic targets. [PDF]

Sci Rep
Fadhal E.
europepmc   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

<i>RGS4</i> in gastric cancer: A multifaceted regulator of focal-adhesion-kinase -phosphatidyl-inositol-3-kinase - protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression. [PDF]

World J Gastroenterol
Yang Y, Chen WM.
europepmc   +1 more source

Loss of METTL3 m6A methyltransferase results in short‐term progression and poor treatment outcome of bladder cancer patients

International Journal of Cancer, Volume 158, Issue 3, Page 763-774, 1 February 2026.
What's new? Bladder cancer exhibits a highly heterogeneous molecular landscape and treatment response. The dysregulation of RNA modifications such as m6A has been involved in cancer initiation and progression. This study comprehensively analyzed the expression of the main catalytic component of the m6A methylation machinery in bladder tumors across one
Katerina‐Marina Pilala, Stella Koroneou, Maria‐Alexandra Papadimitriou, Konstantina Panoutsopoulou, Konstantinos Soureas, Georgios‐Christos Giagkos, Panagiotis Levis, Dimitrios Linardoutsos, Konstantinos Stravodimos, Margaritis Avgeris, Andreas Scorilas   +10 more
wiley   +1 more source

[Expression of Concern] PI3K/Akt signaling pathway‑induced heme oxygenase‑1 upregulation mediates the adaptive cytoprotection of hydrogen peroxide preconditioning against oxidative injury in PC12 cells. [PDF]

Int J Mol Med
Mo L, Yang C, Gu M, Zheng D, Lin L, Wang X, Lan A, Hu F, Feng J.   +8 more
europepmc   +1 more source

Multi‐Omics Revealed the Effects of Intrauterine Hyperglycemia Exposure on the Development of Skeletal Muscle in Offspring

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Gestational diabetes mellitus (GDM), a common pregnancy complication characterized by maternal hyperglycemia, negatively impacts offspring health. Skeletal muscle, a critical tissue for glucose and lipid metabolism, is especially vulnerable to prenatal environmental insults.
Rui Liu, Junsen She, Xinyuan Li, Yishang Yan, Jiaying Mo, Jianzhong Sheng, Hongbo Yang, Hefeng Huang   +7 more
wiley   +1 more source

NEDD4L knockdown reduced lipid accumulation in non-alcoholic fatty liver disease by promoting the activity of PI3K/AKT signaling pathway. [PDF]

Eur J Med Res
Zhou J, Li W, Chi X, Li D, Yang C, Duan Z.   +5 more
europepmc   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source