Results 151 to 160 of about 85,248 (244)

Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes. [PDF]

Cancers (Basel)
Singh SR, Bhaskar R, Ghosh S, Yarlagadda B, Singh KK, Verma P, Sengupta S, Mladenov M, Hadzi-Petrushev N, Stojchevski R, Sinha JK, Avtanski D.   +11 more
europepmc   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

The FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang, Min Peng, Gerson Dierley Keppeke, Li‐Kuang Tsai, Ziheng Zhang, Li‐Mei Pai, Li‐Ying Sung, Ji‐Long Liu   +7 more
wiley   +1 more source

MicroRNAs as Sensitizers of Tyrosine Kinase Inhibitor Resistance in Cancer: Small Molecule Partnerships. [PDF]

Pharmaceuticals (Basel)
Campos-Parra AD, Sánchez-Marín D, Acevedo-Sánchez V.   +2 more
europepmc   +1 more source

ZNF224 enhances the oncogenic function of p21 via p53 and AKT pathways in melanoma

The FEBS Journal, EarlyView.
KRAB zinc finger protein ZNF224 acts as an oncogenic factor in melanoma cells, enhancing p21 cytosolic retention and impairing nuclear p21 cytostatic activity through stimulation of the AKT pathway. Furthermore, ZNF224 regulates transcriptional expression levels of p21 via p53.
Leandra Sepe, Umberto Candia, Dario Sasso del Verme, Elvira Toscano, Marianna Toriello, Gaetano Sodaro, Roberta Rapuano, Simona Romano, Michela Grosso, Giovanni Paolella, Angelo Lupo, Paola Costanzo, Elena Cesaro   +12 more
wiley   +1 more source

A novel role for nonactin: interfering with G-quadruplex in RET-driven medullary thyroid cancer. [PDF]

BMC Cancer
Alqahtani T, Alsubait A, Aloumi M, Alamer A, Alomari G, Alwassil OI, Obaidullah AJ, Alghamdi SS.   +7 more
europepmc   +1 more source

Central mechanisms of emesis: A role for GDF15

Neurogastroenterology &Motility, Volume 37, Issue 3, March 2025.
Abstract Background Nausea and emesis are ubiquitously reported medical conditions and often present as treatment side effects along with polymorbidities contributing to detrimental life‐threatening outcomes, such as poor nutrition, lower quality of life, and unfavorable patient prognosis.
Tito Borner, Allison M. Pataro, Bart C. De Jonghe   +2 more
wiley   +1 more source

Targeted Therapies for Slow-Flow Vascular Malformations. [PDF]

Australas J Dermatol
Li GX, Sebaratnam DF, Pham JP.
europepmc   +1 more source

AEBP1 inhibition reduces cell growth and PI3K/AKT pathway while less regulates cell mobility in hepatocellular carcinoma. [PDF]

World J Surg Oncol
Liu L, Cai Q, Wu D, Li S, Liu D, Zheng J.   +5 more
europepmc   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

Shexiang Baoxin Pills alleviate doxorubicin-induced cardiotoxicity via the reactive oxygen species-mediated AKT/Bcl-2 pathway. [PDF]

Medicine (Baltimore)
Wang S, Chen M, Qian Y, Chen X, Xu W.
europepmc   +1 more source