Results 151 to 160 of about 262,485 (201)

Network centric identification of PI3K/Akt hub proteins as key oncogenic drivers and therapeutic targets. [PDF]

Sci Rep
Fadhal E.
europepmc   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

SHED-Derived Exosomes Attenuate Osteoclastogenesis to Ameliorate Apical Periodontitis in Rats. [PDF]

Int Dent J
Wang S, Dai Z, Huo L, Yang R, Huang G, Fang H, Chen R, Yang H, Wu J.   +8 more
europepmc   +1 more source

FNDC1 Competitively Binds Gβ2 to Suppress the β‐Catenin–Destruction Complex and Promote Gastric Cancer Malignancy

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
FNDC1 competitively binds Gβ2 to suppress the β‐catenin–destruction complex and promote the malignant behavior of gastric cancer (GC) by the following mechanism: elevated FNDC1 competes with Dvl for binding to Gβ2, thereby reducing Dvl–Gβ2 interaction; this reduction inhibits Dvl degradation in the cytoplasm; increased Dvl recruits Axin1, thereby ...
Wenyu Gao, Hao Chen, Fangyu Lin, Jialin Liu, Tingxuan Huang, Han Wang, Xiaojiao Weng, Xinli Wang, Xiaoyan Lin, Tao Jiang   +9 more
wiley   +1 more source

Kaempferol inhibits osteoclast differentiation and bone resorption by targeting the TNF-α/NF-κB and SRC/PI3K/AKT signaling pathways. [PDF]

Sci Rep
Yu Q, Jiang T, Zhao Y, Liu Z, Guan Z.
europepmc   +1 more source

CSDE1 Drives Glycolysis and the Progression of Prostate Cancer Through RAC1‐Dependent RAS/MAPK Activation

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
The mechanism by which CSDE1 promotes prostate cancer progression through RAC1‐dependent RAS/MAPK activation and enhanced glycolysis. ABSTRACT Prostate cancer (PCa) remains a leading cause of cancer‐related morbidity and mortality among men, necessitating the elucidation of molecular drivers behind its progression.
Zhen Yin, Zefeng Wang, Wei Gong, Zitao Wang, Zongze Li, Lizhe Xu, Jinzhuo Ning, Lei Gao, Tiejun Pan, Weimin Yu, Yu Zhou, Jinbo Sun, Fan Cheng   +12 more
wiley   +1 more source

<i>RGS4</i> in gastric cancer: A multifaceted regulator of focal-adhesion-kinase -phosphatidyl-inositol-3-kinase - protein-kinase-B signaling and epithelial-mesenchymal transition beyond tumor progression. [PDF]

World J Gastroenterol
Yang Y, Chen WM.
europepmc   +1 more source

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Regulatory role of ezrin in esophageal cancer progression via the PI3K-AKT signaling pathway. [PDF]

Hereditas
Zhang Y, Zhao Q, Du J.
europepmc   +1 more source

Exploring the Therapeutic Potential of Cannabidiol in Cutaneous Squamous Cell Carcinoma: An Integrated Computational and Experimental Study

International Journal of Quantum Chemistry, Volume 126, Issue 5, March 5, 2026.
Cannabidiol (CBD) exhibits increased reactivity, stronger CB1 receptor binding, and enhanced cytotoxicity against A431 squamous carcinoma cells compared to 5‐fluorouracil (5‐FU). Integrated DFT, molecular docking, and experimental analyses demonstrate CBD's improved stability and binding affinity, highlighting its potential as an alternative ...
Andrea Jess Josiah, Krishna Kuben Govender, Penny Poomani Govender, Werner Cordier, Margo Nell, Suprakas Sinha Ray   +5 more
wiley   +1 more source