Results 151 to 160 of about 260,711 (183)

γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway. [PDF]

Front Pharmacol
Wei J, Xie J, He Z, Feng X.
europepmc   +1 more source

Emerging Role of ctDNA Fragmentomics and Epigenetic Signatures in the Early Detection, Minimal Residual Disease Assessment, and Precision Monitoring of Renal Cell Carcinoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Renal cell carcinoma (RCC) presents a significant global health challenge, with a substantial proportion of patients diagnosed with advanced or metastatic disease due to the limitations of current diagnostic imaging and the lack of validated non‐invasive biomarkers.
Hossam Kamli, Najeeb Ullah Khan
wiley   +1 more source

Exploring the mechanism of Danggui Niantong Decoction in the treatment of rheumatoid arthritis based on network pharmacology, Mendelian randomization, molecular docking and molecular dynamics simulation. [PDF]

Medicine (Baltimore)
Wang H, Fan B, Liu M, Shu Q, Huang Y, Sun Q, Wang H.   +6 more
europepmc   +1 more source

Trichomonosis, a common curable STI, and prostate carcinogenesis—A proposed molecular mechanism [PDF]

, 2011
Siobhan Sutcliffe, Calvin Neace, Nancy S. Magnuson, Raymond Reeves, J. F. Alderete, Joseph Heitman   +5 more
core   +3 more sources

Unlocking the Therapeutic Potential of Integrin‐Linked Kinase Inhibitors in Bioengineered 3D Breast Tumor Stroma Models

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
3D cancer models provide a more reliable representation of drug responses compared to 2D cell culture owing to their 3D architecture and facilitation of cell‐extracellular matrix interactions. In this study, we engineered dense compartmentalized 3D tumoroids composed of breast tumor mass and a surrounding stromal compartment replicating either breast ...
Salma T. Rafik, Anuja Upadhyay, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

NRas Nanoclusters Mediate Crosstalk Between BRAF/ERK and PI3K/AKT Signaling in Melanoma Cells. [PDF]

Int J Mol Sci
Yakovian O, Sajman J, Sherman E.
europepmc   +1 more source

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

Systematic understanding of mechanism of Shenfu decoction improve the prognosis of ischemic stroke using a network pharmacology and animal experiment approach. [PDF]

J Tradit Chin Med
Wei Z, Changhong R, Chen G, Jun XU, Xiaodan WU, Yong Y.   +5 more
europepmc   +1 more source

HOXB4 Promotes Bladder Cancer Progression in Part Through Transcriptional Activation of Smoothened

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
HOXB4 is overexpressed in bladder cancer and associated with poor prognosis. By transcriptionally activating Smoothened (SMO), HOXB4 amplifies SMO–GLI signaling to promote tumor growth and metastatic behavior. This graphical abstract highlights the HOXB4–SMO axis as a key driver of bladder cancer progression and a potential target for future ...
Zhaoheng Jin, Wenjie Yang, Yueqiang Peng, Lin Ma, Ziyi Li, Jie Dong, Zhigang Ji   +6 more
wiley   +1 more source

Upregulation of LTF promotes left-sided colorectal cancer development via activating PI3K/AKT pathway. [PDF]

Cell Adh Migr
Chen P, Zhang M, Bai X.
europepmc   +1 more source