Results 171 to 180 of about 85,248 (244)

Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives

American Journal of Hematology, Volume 100, Issue S4, Page 30-50, June 2025.
ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley   +1 more source

Molecular characterisation of ret tyrosine kinase signalling [PDF]

, 2005
Arighi, Elena
core  

A clinically feasible multiplex proteomic immunoassay as a novel functional diagnostic for pancreatic ductal adenocarcinoma [PDF]

, 2017
Azar, Riad R, Cao, Dengfeng, Early, Dayna S, et al,, Gao, Feng, Kushnir, Vladamir M, Li, Lin, Lim, Kian-Huat, Luo, Jingqin, Mullady, Daniel K, Wang-Gillam, Andrea   +10 more
core   +2 more sources

KIF3C inhibits the progression and proliferation of colorectal cancer. [PDF]

BMC Gastroenterol
Diallo MT, Chen B, Yao Q, Yan Z, Sun Q, Wang D.   +5 more
europepmc   +1 more source

Potential New Expression Biomarkers for Anorexia Nervosa

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 4, June 2025.
ABSTRACT Anorexia nervosa (AN) is a psychiatric disorder with an estimated heritability of around 70%. Although the largest meta‐analysis of genome‐wide association studies on AN identified independent risk‐conferring loci for the disorder, the molecular mechanisms underlying the genetic basis of AN remain to be elucidated.
Camille Verebi, Nicolas Lebrun, Justine Vily Petit, Odile Viltart, Philibert Duriez, Benjamin Saint‐Pierre, Philip Gorwood, Nicolas Ramoz, Thierry Bienvenu   +8 more
wiley   +1 more source

Quercetin Induces Apoptosis Through Downregulating P4HA2 and Inhibiting the PI3K/Akt/mTOR Axis in Hepatocellular Carcinoma Cells: An In Vitro Study. [PDF]

Cancer Rep (Hoboken)
Zhang J, Guo J, Qian Y, Yu L, Ma J, Gu B, Tang W, Li Y, Li H, Wu W.   +9 more
europepmc   +1 more source

Recent Findings in N6‐Methyladenosine Modification and Significance in Pancreatic Cancer

Cancer Medicine, Volume 14, Issue 11, June 2025.
ABSTRACT Background RNA modifications are widely detected in cells and are involved in RNA structural stabilization and regulation of gene expression. In cancer cells, RNA modifications are altered, resulting in abnormal expression of numerous genes and promoting cancer growth. N1‐methyladenosine (m1A), N6‐methyladenosine (m6A), N3‐methylcytosine (m3C),
Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Sarah Rennie, Ken Ofusa, Toru Kitagawa, Hideshi Ishii   +8 more
wiley   +1 more source

The Role of RAS in CNS Tumors: A Key Player or an Overlooked Oncogene? [PDF]

Int J Mol Sci
de Souza Barbosa I, Pilotto Heming C, Moura Neto V, Aran V.   +3 more
europepmc   +1 more source

GABRP Mediates GABA‐A Receptor to Shape Tumor Immunosuppressive Microenvironment and Promote Tumor Immune Escape and Corresponding Targeted Therapy

Cancer Medicine, Volume 14, Issue 11, June 2025.
Beyond its well‐established role in suppressing neuronal excitability, GABA (γ‐aminobutyric acid) has been shown to inhibit immune cell functions. Cancer cells exploit GABA signaling to modulate the tumor microenvironment and impair normal immune cell activities, thereby facilitating immune evasion.
Wu Cen, Genyuan Fu, Xiaoyu Wang, Ruting Wei, Xingwang Zhou, Wei Teng, Yuanguo Ling, Jiaze Tang, Zhongan Wang, Liangzhao Chu   +9 more
wiley   +1 more source

To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway.

World J Gastrointest Oncol
Bao ZC, Liu ZD, Zhang Y, Dai HJ, Jia H, Ren F, Li N, Zhao L, Wang YW, Lv SY, Zhang Y.   +10 more
europepmc   +1 more source