Results 181 to 190 of about 262,485 (201)

SLC12A8 Drives Immune Evasion and Metastasis in Luminal B Breast Cancer by Inducing CD8+ T‐Cell Exhaustion via the TLR Signaling Pathway

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background To investigate the role and mechanism of SLC12A8 in the progression of Luminal B breast cancer. Methods Data from TCGA, GTEx, and HPA databases were used to analyze SLC12A8 expression and its prognostic value in breast cancer. qPCR was performed to validate SLC12A8 expression in various breast cancer cell lines.
Zhiyong Liu, Ran Chen
wiley   +1 more source

Evaluation of the mechanism underlying melatonin action in cholestatic liver disease treatment via network pharmacology, molecular docking, and in vivo experiments. [PDF]

PLoS One
Li T, ZhenYu J, Jing W.
europepmc   +1 more source

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source

GANT61 suppresses proliferation and induces apoptosis in ALK-Positive anaplastic large cell lymphoma via modulating the Hh-PIK3IP1-Akt signaling axis. [PDF]

Ann Hematol
Chen H, Gao J, Li C, Han Y, Liu S, Zhu X.   +5 more
europepmc   +1 more source

Mechanistic role of GNE‐987 targeting BRD4‐HCP5 axis in pediatric T‐cell acute lymphoblastic leukemia

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
Abstract This study aims to explore the mechanism of action of the Bromodomain‐containing protein 4 (BRD4) inhibitor GNE‐987 in the treatment of pediatric T‐cell Acute Lymphoblastic Leukemia (T‐ALL), focusing on its effect in inhibiting T‐ALL cell proliferation by activating the HLA Complex P5 (HCP5) Super‐enhancer.
Xu Sang, Mengying Jiang, Yanchun Guan, Xin Chen, Zhen Zhang, Yumeng Wu, Wansheng Peng   +6 more
wiley   +1 more source

Emerging role of histone and non-histone lactylation in metabolic reprogramming of female-specific malignancies. [PDF]

World J Surg Oncol
Sun C, Hu D, Peng W, Cui Z, Lin Y.
europepmc   +1 more source

Altered DNA Methyltransferase Expression in Pulmonary Large‐Cell Neuroendocrine Carcinoma: Pilot Experimental Data Targeted DNMT1, DNMT3A, and DNMT3B

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Introduction Large cell neuroendocrine carcinoma (LCNEC) is a subtype of non‐small‐cell lung carcinoma with poorly understood methylation characteristics, including the activity of DNA methyltransferases. Despite the pivotal role of DNA methyltransferases in epigenetic regulation, their expression profile in LCNEC remains unexplored.
Adam Put, Katerina Smesny Trtkova, Marcel Mittak, Petra Herentinova, Jana Vaculova, Radoslava Cernekova, Jozef Skarda   +6 more
wiley   +1 more source

MicroRNA-195-5p Targets MYB to Regulate Proliferation and Malignant Metastasis in Triple-Negative Breast Cancer via PI3K/AKT/mTOR Signaling. [PDF]

Breast J
Tang K, Bai S, Zhou Q, Liu S, Yin L, Tong Y, Long L, Ou L, Yin Q.   +8 more
europepmc   +1 more source

Elucidating Trigonelline's Therapeutic Mechanisms for Traumatic Brain Injury Through Integrated Network Pharmacology and In Vivo Validation

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Trigonelline alleviates traumatic brain injury (TBI) by attenuating oxidative stress and neuroinflammation. It inhibits MAPK signaling–mediated neuronal apoptosis and reduces cerebral edema via downregulation of AQP4 and MMP‐9, thereby maintaining blood–brain barrier integrity.
Qian Zhang, Yuefan Zhang, Zhibing Song, Zixiang Tang, Guoqiang Wang, Xiang Yang, Jincai Li, Tiejun Li   +7 more
wiley   +1 more source

Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy. [PDF]

Sci Rep
Xie X, Liu C, Liu X, Hou L, Zhang Y, Huang L, Peng W, Liu Y.   +7 more
europepmc   +1 more source