Results 181 to 190 of about 85,248 (244)

MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction. [PDF]

Int J Mol Med
Zhou H, Gong H, Zeng X, Zeng C, Liu D, Liu J, Zhang Y.   +6 more
europepmc   +1 more source

Extracellular vesicle‐LncRNA HOTAIR modulates esophageal cancer chemoresistance and immune microenvironment via miR‐375/CDH2 pathway

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
Abstract Chemoresistance and immune evasion remain significant barriers to effective esophageal cancer (EC) treatment. This study explores the mechanistic role of extracellular vesicles (EVs) delivering LncRNA HOTAIR in modulating these processes. Using transcriptomic profiling, LncRNA HOTAIR was identified as a critical factor in EC progression.
Tayier Tuersong, Munire Shataer, Yan Chen, Gaosi Chen, Xiaoling Li, Linjie Lei, Ayiguli Younusi, Liangying Ma   +7 more
wiley   +1 more source

Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy. [PDF]

Mol Med Rep
Wang H, Cheng G, Zhang S, Qu H, Zhao X, Yang A, Sun X, Pan H.   +7 more
europepmc   +1 more source

Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential

Cancer Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background Cancer represents a complex group of diseases characterized by abnormal cell proliferation, invasion, and metastasis. These features pose significant challenges to conventional therapeutic approaches, necessitating the development of more targeted and effective treatment strategies.
Sumaira Anjum, Mariam Hashim, Maham Imran, Sundus Babur, Sanniah Adnan, Christophe Hano, Wisam Nabeel Ibrahim   +6 more
wiley   +1 more source

The intersection of aging and estrogen in osteoarthritis. [PDF]

NPJ Womens Health
Atasoy-Zeybek A, Showel KK, Nagelli CV, Westendorf JJ, Evans CH.   +4 more
europepmc   +1 more source

Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
ACT001 disrupts the MDK/c‐Myc complex, enhancing c‐Myc ubiquitination and overcoming temozolomide resistance in glioma. Combining ACT001 with temozolomide synergistically inhibits tumour growth and progression, offering a promising therapeutic strategy for glioma patients, particularly those with high MDK expression.
Xiaonan Xi, Xiaojing Ding, Qianqian Wang, Ning Liu, Bangmao Wang, Genbei Wang, Weilong Zhong, Yaxin Lu   +7 more
wiley   +1 more source

Chronic intermittent hypoxia affects the expression of IRS - 2/p - Akt/GSK - 3 in the liver of SD rats and its impact on glucose metabolism. [PDF]

Sleep Breath
Wang H, Guo T.
europepmc   +1 more source

Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease)

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
(A) Post hoc pairwise comparisons between the four studied groups regarding the log2 of serum fold change of CircFUNDC1. There were significant differences between CRC, UC, or CD and controls. p values (Controls vs. UC = < 0.001, Controls vs. CD = < 0.001, Controls vs. CRC = < 0.001, UC vs. CD = 1.000, UC vs. CRC = 0.194, CD vs. CRC = 0.255).
Marwa A. Ali, Olfat G. Shaker, Eman M. Ezzat, Abeer A. Khalefa, Naglaa A. Ahmed, Raghda Yahia Abu El‐Ela, Amal A. Ibrahim Amin, Fatma Abdel Hamid Mohamed, Marwa Mamdouh Ahmed Abdelhafeez, Mohamed Saad Zaghloul Ahmed, Marwa N. AbdelHafez, Abdulrhman Khaled Al Abdulqader, Reham Fares   +12 more
wiley   +1 more source

YY1-induced DDX18 modulates EMT via the AKT/mTOR pathway in esophageal cancer: a novel therapeutic target. [PDF]

J Transl Med
Ma X, He Y, Yang Y, Lu T, Tang Z, Cui Y, Wang R.   +6 more
europepmc   +1 more source

Mago nashi controls auxin‐mediated embryo patterning in Arabidopsis by regulating transcript abundance

New Phytologist, Volume 247, Issue 1, Page 14-23, July 2025.
Liping Liu, Wen Gong, Regina Stöckl, Philipp Denninger, Uwe Schwartz, Mark A. Johnson, Thomas Dresselhaus   +6 more
wiley   +1 more source