Results 191 to 200 of about 262,485 (201)

The PKA/MBD2 Axis Transcriptionally Represses INPP5A to Modulate PI3K/Akt Signaling and Accelerate Pituitary Tumorigenesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
Loss of INPP5A in PitNETs disrupts IP3 clearance and drives aberrant PI3K/Akt activation. PKA‐dependent phosphorylation stabilizes MBD2 via 14‐3‐3σ, sustaining transcriptional silencing of INPP5A. MBD2 inhibition sensitizes tumors to standard treatments and limits PitNET growth.
Qian Jiang, Yaorui Wang, Zihan Wang, Quanji Wang, Sihan Li, Linpeng Xu, Zhuo Zhang, Zhoubin Tan, Huaqiu Zhang, Kai Shu, Ting Lei, Yimin Huang, Zhuowei Lei   +12 more
wiley   +1 more source

MYBL2 regulates the expression of CENPF in lung adenocarcinoma and promotes tumor development and metastasis through AKT pathway activation. [PDF]

Eur J Med Res
Liu Y, Yu F, Jiang J, Ma H.
europepmc   +1 more source

Integration of single‐cell and bulk transcriptomics reveals the association of manganese metabolism‐related genes with prognosis and immune infiltration in lung adenocarcinoma

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
This study developed a prognostic model for lung adenocarcinoma using manganese metabolism‐related genes (MRGs). Nine key MRGs were identified via multi‐omics and LASSO‐Cox analyses to calculate a risk score. The model showed robust predictive performance in both training and validation cohorts.
Hongliang Li, Shuzhen Wei, Wei Li, Junxia Sun, Yi Wang   +4 more
wiley   +1 more source

TMEM121 suppresses cervical cancer cell proliferation and migration via interaction with the ERK pathway. [PDF]

Am J Cancer Res
Wang H, Xu S, Li S, Lin M, Jiao Z, Zhao J, Wu D, Huang Y, Liu S, Ge S, Wu X, Li F, Guo L, Fan X.   +13 more
europepmc   +1 more source

Multi‐omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
We developed three UC clusters, applicable for MIBC and NMIBC, which were validated using transcriptomic- and proteomic datasets. Publically available UC cell lines were assigned to the clusters, to have in vitro models representing each cluster. The clusters differ in molecular and biological signatures, with distinct prognostic and therapeutic ...
Nils C. H. van Creij, Piotr Tymoszuk, Florian Handle, Andreas Seeber, Teresa Sellemond, Agnieszka Martowicz, Eva Comperat, Hamed Wafa, Steffen Ormanns, Michael Günther, Walther Parson, Maxim Noeparast, Frédéric R. Santer, José Daniel Subiela, Petros Grivas, Roger Li, Zoran Culig, Renate Pichler   +17 more
wiley   +1 more source

Retracted: Maternally-Expressed Gene 3 (MEG3)/miR-143-3p Regulates Injury to Periodontal Ligament Cells by Mediating the AKT/Inhibitory kB Kinase (IKK) Pathway. [PDF]

Med Sci Monit
Dong Y, Feng S, Dong F.
europepmc   +1 more source

Disrupting Akt-Wnt/β-catenin signaling suppresses glioblastoma stem cell growth and tumor progression in immunocompetent mice. [PDF]

J Neurooncol
Sarkar MM, Gonsalves N, Davarzani A, Mitchell E, Singh AM, Karumbaiah L, Stice SL.   +6 more
europepmc   +1 more source

ANXA1 overexpression promotes B cell acute lymphoblastic leukemia progression and resistance by regulating fatty acid metabolism through PI3K/Akt signaling. [PDF]

Mol Cell Biochem
Liu P, Ma D, Pan C, Kang Q, Wang Y, Zhang M, Wang J.   +6 more
europepmc   +1 more source

Systematic understanding of mechanism of Shenfu decoction improve the prognosis of ischemic stroke using a network pharmacology and animal experiment approach. [PDF]

J Tradit Chin Med
Wei Z, Changhong R, Chen G, Jun XU, Xiaodan WU, Yong Y.   +5 more
europepmc   +1 more source

γ-Mangostin attenuates osteoclastogenesis and bone resorption by suppressing the PI3K/AKT/NF-κB pathway. [PDF]

Front Pharmacol
Wei J, Xie J, He Z, Feng X.
europepmc   +1 more source