Mechanisms and Therapeutic Strategies of Macrophage Polarization in Intervertebral Disc Degeneration
JOR SPINE, Volume 8, Issue 2, June 2025.This article reviews the role of macrophage polarization in IVDD. It details how macrophage polarization influences various pathomechanisms of disc degeneration, including the inflammatory microenvironment, NPCs senescence, angiogenesis, fibrosis, and neural ingrowth and sensitization.
Kaiyuan Zheng +6 more
wiley +1 more source
DNA dioxygenase TET2 deficiency aggravates sepsis-induced acute lung injury by targeting ITGA10 via the PI3K/AKT signaling pathway. [PDF]
Cell Mol Biol LettFu H +7 more
europepmc +1 more source
Beyond Conventional Approaches: The Revolutionary Role of Nanoparticles in Breast Cancer
MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.This review explores integrated approach of nanotechnology to breast cancer diagnosis and treatment. We highlight imaging techniques for tumor detection and biomarker analysis in biological samples for early diagnosis. Advanced therapies, including targeted drug delivery and antibody‐drug conjugates, enable precise medication transport to cancer cells,
Mohan Liu +7 more
wiley +1 more source
Matrix stiffness enhances viability, migration, invasion and invadopodia formation of oral cancer cells via PI3K/AKT pathway in vitro. [PDF]
Eur J Med ResZhang Z +5 more
europepmc +1 more source
PRMT5 Promotes Pancreatic Cancer Tumorigenesis via Positive PRMT5/C‐Myc Feedback Loop
MedComm, Volume 6, Issue 6, June 2025.By forming a positive feedback loop with c‐Myc, PRMT5 promoted the pancreatic cancer tumorigenesis. Inactivation of PRMT5 with small molecular inhibitors led to suppressed proliferation, colony formation, enhanced apoptosis, and cell cycle arrest. Targeting PRMT5 exhibited promising therapeutic effect for pancreatic cancer . ABSTRACT The oncogenic role
Fan Yang +7 more
wiley +1 more source
Ticagrelor inhibits the growth of lung adenocarcinoma by downregulating SYK expression and modulating the PI3K/AKT pathway. [PDF]
Sci RepSong Y, He S, Zeng L, He Y, Huang L.
europepmc +1 more source
MedComm, Volume 6, Issue 6, June 2025.In this review, we first introduced the current application scenarios for radiotherapy in tumor treatment, the molecular mechanisms underlying anticancer effects of radiotherapy in treatment of cancer, and the side‐effects of radiotherapy. Second, we pay attention to discuss the main types of radiosensitizers and their latest applications and ...
Yuanyuan Zhao +5 more
wiley +1 more source
A molecular approach combined with American Thyroid Association classification better stratifies recurrence risk of classic histology papillary thyroid cancer [PDF]
, 2019 Baranski, Thomas +8 more
core +1 more source
Enhancing doxorubicin's anticancer impact in colorectal cancer by targeting the Akt/Gsk3β/mTOR-SREBP1 signaling axis with an HDAC inhibitor. [PDF]
Korean J Physiol PharmacolZhao H, Wu Y, Kim SM.
europepmc +1 more source
Lactylation: From Homeostasis to Pathological Implications and Therapeutic Strategies
MedComm, Volume 6, Issue 6, June 2025.Lactylation, a novel post‐translational modification derived from lactate metabolism, plays a critical role in cellular homeostasis and disease pathogenesis. Under physiological conditions, lactylation regulates gene expression, immune responses, and metabolic adaptation. However, dysregulated lactylation is implicated in various pathological processes,
Xi Chen +6 more
wiley +1 more source