Results 201 to 210 of about 85,248 (244)

Ginkgolide B Inhibits EMT and Promotes Pyroptosis in Gastric Cancer via AKT/mTOR Pathway. [PDF]

Drug Des Devel Ther
Lu X, Zhang Y, Wang R, Li Z.
europepmc   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

Exosomes from human umbilical cord mesenchymal stem cells promote the growth of human hair dermal papilla cells. [PDF]

PLoS One
Chen YC, Tsai WC, Li ZX, Lin WJ, Lin HY, Hsieh YJ, Wang KH, Chen YY, Hwang TL, Lin TY.   +9 more
europepmc   +1 more source

Fexofenadine Overcomes Osimertinib Resistance by Inhibiting c‐Met in Non‐Small Cell Lung Cancer

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Fexofenadine was identified as a new Met inhibitory drug by a computational drug repurposing tool called “DRAR‐CPI” via chemical‐protein interactome analysis of known Met inhibitors. It was shown to overcome osimertinib resistance in non‐small cell lung cancer by inhibiting Met in vitro and in vivo.
Kenneth K. W. To, Kwong‐Sak Leung, William C. Cho   +2 more
wiley   +1 more source

Exploring the potential mechanism of Polygonatum sibiricum for Alzheimer's disease based on network pharmacology and molecular docking: An observational study. [PDF]

Medicine (Baltimore)
Luo L, Pan Y, Chen F, Zhang Z.
europepmc   +1 more source

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

KLC3 activates PI3K/AKT signaling and promotes ovarian cancer cell proliferation and migration through COL3A1. [PDF]

Oncol Rep
Yang J, He R, Zhang X, Wang X, Liu M, Liu X, Li Y.   +6 more
europepmc   +1 more source

Alcohol Dehydrogenase 4‐Mediated Retinol Metabolism Inhibits Hepatocellular Carcinoma Progression Through Inhibiting the Wnt/β‐Catenin Pathway

MedComm – Oncology, Volume 4, Issue 2, June 2025.
The downregulation of ADH4 expression induces hepatocyte apoptosis, thereby contributing to liver fibrosis and the initiation of hepatocellular carcinoma (HCC). Moreover, sustained suppression of ADH4 in HCC cells disrupts retinoic acid synthesis, leading to reduced expression of the Wnt/β‐catenin signaling inhibitor WIF‐1 via RARs/RXRs‐mediated ...
Jiaying Li, Mingshu Gao, Yanan Zhang, Dawen Liao, Feng Zhou, Zhaohui Zhang, Lele Ji, Yilin Zhao, Qichao Huang, Qian Bi, Nan Wang   +10 more
wiley   +1 more source

Sodium aescinate protects renal ischemia-reperfusion and pyroptosis through AKT/NLRP3 signaling pathway. [PDF]

Ren Fail
Xin L, Kanghao N, Jiacheng L, Xiaodong Y, Juhan Y, Xinyang Z, Xiangdong L.   +6 more
europepmc   +1 more source

CNDP1 Overexpression by Promoter Hypomethylation Predicts Poor Prognosis and Immunotherapy Response in Mucosal Melanoma

Cancer Science, Volume 116, Issue 6, Page 1671-1678, June 2025.
The epigenetic status of CNDP1 serves as a dependable biomarker for mucosal melanoma. Hypomethylation of its promoter region can lead to the overexpression of CNDP1, a condition that correlates with an unfavorable prognosis and diminished response to immunotherapy in melanoma patients.
Jia Jia, Junjie Gu, Lina Gao, Kaihua Liu, Jie Dai, Fanshuang Zhang, Pei Yuan, Lili Mao, Xiaoting Wei, Yang Shao, Jun Guo, Yanfeng Xi, Jianming Ying, Lu Si   +13 more
wiley   +1 more source