Results 211 to 220 of about 85,248 (244)

Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis. [PDF]

Sci Rep
Gu P, Chen J, Xin J, Chen H, Zhang R, Chen D, Zhang Y, Shao S.   +7 more
europepmc   +1 more source

MIB2‐Mediated SUZ12 Ubiquitination Regulates Clonal Proliferation in Patients With Paroxysmal Nocturnal Haemoglobinuria

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Secondary gene mutations are one of the main mechanisms underlying paroxysmal nocturnal haemoglobinuria (PNH) clone proliferation. Our previous studies showed that SUZ12 participates in PNH clone proliferation by regulating H3K27me3. However, the mechanism underlying the SUZ12 function remains unclear. Immunoprecipitation and mass spectrometry
Hui Liu, Lijie Zeng, Chaomeng Wang, Yingying Chen, Liyan Li, Zhaoyun Liu, Honglei Wang, Rong Fu   +7 more
wiley   +1 more source

Taletrectinib promotes pyroptosis in colorectal carcinoma via SRC/AKT/mTOR axis inhibition. [PDF]

Sci Rep
Zhang T, Zou Y, Zhang SH, Wang YY, He S, Yuan W, Yang M, Liu T, Deng SH, Wu DM, Xu Y.   +10 more
europepmc   +1 more source

Multi‐Omic Analysis of Glutamate Excitotoxicity in Primary Neuronal Cultures

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
Our study on rat neuron cells found 250 μM glutamate to be toxic, causing neuron death. We identified genes in pathways linked to apoptosis, neuron plasticity, and cell signaling, along with proteins regulating the cell cycle and tumor proliferation.
Jennifer H. Nguyen, Xiaolu Zhang, Hunter M. Eby, Khaled Alganem, William G. Ryan, Ali Sajid lmami, Anna E. Lundh, Anvitha R. Madhavaram, James D. Bretz, Ethel Tackie‐Yarboi, Kelsee Zajac, William S. Messer Jr., Isaac T. Schiefer, Robert E. McCullumsmith   +13 more
wiley   +1 more source

Solid stress compression enhances breast cancer cell migration through the upregulation of Interleukin-6. [PDF]

Front Cell Dev Biol
Azizan F, Sheriff RS, Goh CJH, Chiam KH, Koh CG.   +4 more
europepmc   +1 more source

Therapeutic options for human papillomavirus‐positive tonsil and base of tongue cancer

Journal of Internal Medicine, Volume 297, Issue 6, Page 608-629, June 2025.
Abstract The incidences of human papillomavirus‐positive (HPV+) tonsillar and base tongue squamous cell carcinomas (TSCC and BOTSCC) have increased in recent decades. Notably, HPV+ TSCC and BOTSCC have a significantly better prognosis than their HPV‐negative counterparts when treated with current surgical options, radiotherapy, or intensified ...
Mark Zupancic, Ourania N. Kostopoulou, Linda Marklund, Tina Dalianis   +3 more
wiley   +1 more source

Mechanism of Qigu capsule as a treatment for sarcopenia based on network pharmacology and experimental validation. [PDF]

J Tradit Chin Med
Jinyu S, Fuwei P, Haiya GE, Zongrui Y, Hongsheng Z.   +4 more
europepmc   +1 more source

First Steps toward the Design of Peptides that Influence the Intracellular Palmitoylation Machinery

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Herein, DC peptides consisting of the cell‐penetrating peptide sC18* and a Asp–His–His–Cys (DHHC) motif derived from human ZDHHC palmitoyltransferase are highlighted. DC peptides demonstrate high cellular internalization into various cellular models, exert cytotoxic effects against cancerous cells, and alter the function and localization of known ...
Katharina Stillger, Eric Platz‐Baudin, Florian Friedland, Melina Ruppel, Coco‐Louisa Sticker, Anne Bodenhausen, Erik Noetzel, Ines Neundorf   +7 more
wiley   +1 more source

AP5Z1 affects hepatocellular carcinoma growth and autophagy by regulating PTEN ubiquitination and modulating the PI3K/Akt/mTOR pathway. [PDF]

J Transl Med
Quan Z, Peng B, Hu K, Liang L, Liu M, Liao L, Chen S, Qin J, He S, Li Z.   +9 more
europepmc   +1 more source

WWP1 inhibition suppresses the proliferation of pancreatic cancer cells by regulating the PI3K-AKT pathway. [PDF]

J Gastroenterol
Notoya G, Kishikawa T, Yasugi K, Iwata T, Seimiya T, Miyabayashi K, Takahashi R, Yamamoto K, Ijichi H, Otsuka M, Fujishiro M.   +10 more
europepmc   +1 more source