Results 41 to 50 of about 252,117 (230)

Alternative HER/PTEN/Akt Pathway Activation in HPV Positive and Negative Penile Carcinomas [PDF]

, 2011
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Berney Daniel M., Mesher, D, Frances Hiscock, Berney, Daniel M., Cuzick, Jack, Catherine Corbishley, Lu Yong-Jie, Ng, Mansum, Prowse David M., Corbishley, Catherine, Cuzick, J, Yong-Jie Lu, Lam, W, Ng Mansum, Daniel M. Berney, Stankiewicz, Elzbieta, Mesher, David, Ng, M, Nicholas Watkin, Lam, Wayne, Lu, YJ, Jack Cuzick, Daniel M Berney, Watkin, N, Watkin Nicholas, Lam Wayne, Watkin, Nicholas, David M Prowse, Wayne Lam, David M. Prowse, Corbishley, C, Berney, DM, Prowse, DM, Elzbieta Stankiewicz, David Mesher, Prowse, David M., Hiscock Frances, Lu, Yong Jie, Hiscock, Frances, Stankiewicz Elzbieta, Mesher David, Corbishley Catherine, Hiscock, F, Stankiewicz, E, Mansum Ng, Cuzick Jack   +45 more
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FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

C-terminal binding proteins: Emerging roles in cell survival and tumorigenesis [PDF]

, 2006
Within a cell, the levels and activity of multiple pro- and anti-apoptotic molecules act in concert to regulate commitment to apoptosis. Whilst the balance between survival and death can be tipped by the effects of single molecules, cellular apoptosis ...
Blaydes, J.P., J. P. Blaydes, Bergman, L.M., L. M. Bergman   +3 more
core   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Cigarette-Specific Carcinogen Induces Stabilization of DNA methyltransferases through AKT/GSK3β/βTrCP Pathway in Lung Cancer [PDF]

, 2011
[[abstract]]Background: Most lung cancer cases are caused by cigarette-specific carcinogens, such as nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Previous studies have shown that NNK induces promoter hypermethylation of several tumor
Yi-Shuan Hsieh, 謝翊萱
core  

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Combining Spatial Multi‐Omics Data to Decipher Spatial Domains and Elucidate Cell Heterogeneity Based on Self‐Supervised Graph Learning

Advanced Science, EarlyView.
A self‐supervised multi‐view graph fusion framework integrates spatial multi‐omics, excelling in domain identification and denoising. It reconstructs spatial pseudo‐expression, jointly analyzes multi‐omics data, infers RNA velocity, predicts spatial omics features from single‐cell multi‐omics, and detects spatially dark genes and transcription factors,
Yuejing Lu, Rui Qiao, Ying Li, Junhong Li, Nuoya Yue, Jing Ge, Jiao Wang, Luonan Chen, Peiluan Li   +8 more
wiley   +1 more source

Engineered Carbon Dots from a Traditional Herb Pair Orchestrate Concurrent Antioxidant and AP‐1‐Mediated Inflammation to Attenuate Renal Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study integrates two complementary traditional Chinese medicine components as precursors to synthesize bioactive AM‐AS@CDs. Compared with single‐component CDs, these dual‐component CDs exhibit enhanced antioxidant capacity and superior renoprotective effects.
Bixiao Liu, Fuying Zhu, Zhuqing Wang, Jiawen Chen, Xiaomiao Cui, Congzhong Yang, Yao Peng, Dengyuan Feng, Li Lu, Hui Wei, Xiaozhi Zhao   +10 more
wiley   +1 more source

A yeast gene encoding a protein homologous to the human c-has/bas proto-oncogene product

, 1983
Organisms amenable to easy genetic analysis should prove helpful in assessing the function of at least those proto-oncogene products which are highly conserved in different eukaryotic cells.
Sander, C., Donath, C., Gallwitz, D.
core   +1 more source