An investigation into the mechanisms by which bim gene expression is regulated in sympathetic neurons [PDF]
, 2010 Neuronal apoptosis plays a critical role in development and disease. Developing sympathetic neurons require nerve growth factor (NGF) for their survival and die by apoptosis in its absence.
Hughes, R.
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The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner [PDF]
, 1993 The product of the putative proto-oncogene bcl-3 is an I kappa B-like molecule with novel binding properties specific for a subset of the rel family of transcriptional regulators. In vitro, Bcl-3 protein specifically inhibited the DNA binding of both the
Scott, Martin L. +6 more
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Ras signaling enhances the activity of C/EBPalpha to induce granulocytic differentiation by phosphorylation of serine 248 [PDF]
, 2003 The transcription factor C/EBPa regulates early steps of normal granulocyte differentiation since mice with a disruption of the C/EBPa gene do not express detectable levels of the G-CSF receptor and produce no neutrophils.
Singh, Sheo Mohan
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The granulocytic inducer C/EBPalpha inactivates the myeloid master regulator PU.1 [PDF]
, 2003 Verschiedene Transkriptionsfaktoren spielen eine Rolle in der Entwicklung myeloischer Zellen. PU.1, ein Transkriptionsfaktor aus der ETS-Familie, ist sowohl für die Entwicklung lymphatischer als auch für die Entwicklung myeloischer Zellen von Bedeutung ...
Reddy, Venkateshwar
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The role of the notch signalling pathway in vascular smooth muscle cell apoptosis [PDF]
, 2004 The Notch signalling system is a highly conserved method of cell-to-cell communication involved in cell fate decisions in many cell types. Until recently, the importance of the Notch signalling pathway was recognized in the embryonic but not in the adult
Sweeney, Catherine Helena
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Importância da investigação de proteínas de resistência ABCB1, ABCC1 e LRP e da proteína antiapoptótica Bcl-2 no diagnóstico e no prognóstico de leucemias agudas [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2010A resistência a múltiplas drogas é uma das maiores causas para a falha do tratamento das leucemias ...
Moraes, Ana Carolina Rabello de
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Targeting C-terminal binding proteins (CtBPs) using genetic selection [PDF]
, 2011 There are many protein-protein interactions that are vital for cellular processes such as signal transduction, structural organisation and apoptosis. In this study we decipher the role of the protein-protein interaction of C terminal Binding Proteins ...
Nijjar, Sharandip K.
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Gene mutations and expression in breast cancer [PDF]
, 2000 Bibliography: leaves 163-190.Breast cancer is the most common cause of death amongst women, with the incidence of the disease varying between countries. Like all other cancers, breast cancer is a multigenic disorder with mutations in oncogenes and tumour
Donninger, Howard
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Differentiation of the mononuclear phagocyte system during mouse embryogenesis:the role of transcription factor PU.1 [PDF]
, 1999 During mouse embryogenesis, macrophage-like cells arise first in the yolk sac and are produced subsequently in the liver. The onset of liver hematopoiesis is associated with the transition from primitive to definitive erythrocyte production.
Lichanska, A M +7 more
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The receptor tyrosine kinase RET is a Hsp90 client protein and is degraded upon exposure to 17-AAG. [PDF]
, 2009 Molecular alterations of the receptor tyrosin kinase RET are involved in the pathogenesis of thyroid cancer. Germline point mutations in the extracellular and intracellular domains of the receptor are responsible of a group of inherited cancer diseases ...
Alfano, Luigi
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