Results 201 to 210 of about 49,807 (253)

HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAF^V600E-mutant microsatellite stable colorectal cancer. [PDF]

J Immunother Cancer
Sun Z, Shi M, Xia J, Li X, Chen N, Wang H, Gao Z, Jia J, Yang P, Ji D, Gu J.   +10 more
europepmc   +1 more source

Unique characteristics of autoantibodies targeting MET in patients with breast and lung cancer. [PDF]

JCI Insight
Navon M, Ben-Shalom N, Dadiani M, Mor M, Yefet R, Bakalenik-Gavry M, Chat D, Balint-Lahat N, Barshack I, Tsarfaty I, Nili Gal-Yam E, Freund NT.   +11 more
europepmc   +1 more source

Therapeutic Potentials of MiRNA for Colorectal Cancer Liver Metastasis Treatment: A Narrative Review. [PDF]

Iran J Med Sci
Barjasteh AH, Jaseb Mazhar AleKassar R, Al-Asady AM, Latifi H, Avan A, Khazaei M, Ryzhikov M, Hassanian SM.   +7 more
europepmc   +1 more source

Macrophage and Preeclampsia: Macrophage Polarization Imbalance at the Maternal‐Fetal Interface

Journal of Clinical Laboratory Analysis, Volume 39, Issue 11, June 2025.
The development and progression of preeclampsia (PE) are associated with immune‐inflammatory responses induced by placental dysfunction. The polarization imbalance of decidual macrophages, particularly the increase in M1 polarization, exacerbates placental inflammation.
Yao Wei, Yang Su, Cheng Liu, Xiaolong Ma, Zihui Ling, Yilin Wang, Rui Qiao   +6 more
wiley   +1 more source

PFKP silencing suppresses tumor growth via the AXL-MET axis. [PDF]

Int J Biol Sci
Zhao H, Sun Y, Feng H, Cai J, Liu Y, Li Y, Chen S, Zhou Z, Du Y, Zeng X, Ren H, Su W, Mei Q, Chen G.   +13 more
europepmc   +1 more source

A Single‐Center Study on Frontline Treatment for Multiple Myeloma Patients With 1q Abnormalities

eJHaem, Volume 6, Issue 3, June 2025.
ABSTRACT Introduction Chromosome 1q copy gains (with‐1q‐gain) is a frequently observed genetic abnormality in multiple myeloma (MM) patients. Recent research has demonstrated that 1q gain is a prognostic factor, linked to poorer clinical outcomes. Methods This study was conducted at the Princess Margaret Cancer Centre to examine the clinical outcomes ...
Ashish Patel, Esther Masih‐Khan, Adam Smith, Katherine Lajkosz, Sita Bhella, Christine Chen, Anca Prica, Donna Reece, A. Keith Stewart, Roger Tiedemann, Suzanne Trudel, Chloe Yang, Guido Lancman, Vishal Kukreti   +13 more
wiley   +1 more source

Old players and new insights: unraveling the role of RNA-binding proteins in brain tumors. [PDF]

Theranostics
Wang X, Li J, Zhang C, Guan X, Li X, Jia W, Chen A.   +6 more
europepmc   +1 more source

Pleiotropic Effects of Metformin on the Chemotherapy Response of HPV‐Positive Cancer Cells

Journal of Medical Virology, Volume 97, Issue 6, June 2025.
ABSTRACT Improved treatment strategies for HPV‐positive cancers are urgently required. The viral E6/E7 oncoproteins are essential for the proliferation of HPV‐positive cancer cells and considered attractive therapeutic targets. Metformin is proposed to be repurposed for cancer therapy, but this is under controversial debate.
Alicia Avenhaus, Bianca J. Kuhn, Milica Velimirović, Tobias D. Strobel, Julia Bulkescher, Claudia Lohrey, Jeroen Krijgsveld, Felix Hoppe‐Seyler, Karin Hoppe‐Seyler   +8 more
wiley   +1 more source

Identification of Novel Compounds That Bind to the HGF β-Chain In Silico, Verification by Molecular Mechanics and Quantum Mechanics, and Validation of Their HGF Inhibitory Activity In Vitro. [PDF]

Molecules
Suzuki K, Inoue K, Namiguchi R, Morita S, Hayakawa S, Yokota M, Sakai K, Matsumoto K, Aoki S.   +8 more
europepmc   +1 more source

Beyond Conventional Approaches: The Revolutionary Role of Nanoparticles in Breast Cancer

MedComm – Biomaterials and Applications, Volume 4, Issue 2, June 2025.
This review explores integrated approach of nanotechnology to breast cancer diagnosis and treatment. We highlight imaging techniques for tumor detection and biomarker analysis in biological samples for early diagnosis. Advanced therapies, including targeted drug delivery and antibody‐drug conjugates, enable precise medication transport to cancer cells,
Mohan Liu, Yusi Wang, Yan Li, Yibing Zhang, Bailing Zhou, Lei Yang, Xi Yan, Li Yang   +7 more
wiley   +1 more source