Results 41 to 50 of about 20,082,992 (152)

[G691S, L769L and S836S ret proto-oncogene polymorphisms are not associated with higher risk to sporadic medullary thyroid carcinoma in Chilean patients].

, 2005
Medullary thyroid carcinoma (MTC) may occur either assporadic or as hereditary. Even though the sporadic form corresponds to the majority of cases, thepathogenesis is still unclear. Several polymorphisms of the RET proto-oncogene, including those located
G. NelsonWohllk, C. EmilianoSoto, A. MaritzaBravo, C. PedroBecker   +3 more
semanticscholar   +1 more source

Colorectal Cancer: Epidemiology, Risk Factors, Signaling Pathways, Clinical Features, Screening, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Colorectal cancer is a heterogeneous, adaptive disease shaped by population‐level risk, genomic and epigenetic alterations, tumor ecosystem evolution, and treatment pressure. This review integrates epidemiology, risk factors, signaling networks, clinical presentation, screening, molecular diagnosis, and stage‐ and biomarker‐guided management while ...
Kairui Wan, Ke Tang, Linglong Wang, Qin Tian, Mingwei Zheng, Cheng Qian, Limei Liu   +6 more
wiley   +1 more source

Efficacy and Safety of Initial Low‐Dose, Extended‐Interval Nivolumab Monotherapy in a 91‐Year‐Old Patient With Locally Advanced NSCLC and Poor Performance Status: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT The incidence of non‐small cell lung cancer (NSCLC) increases with age, with approximately half of the cases diagnosed in individuals aged 70 and older. In numerous clinical trials, immune checkpoint inhibitors (ICIs) have demonstrated significant efficacy in treating NSCLC without driver gene mutations.
Dan Kou, Xiang Yan, Qi Huang, Jingye Zhong, Qiongcheng Chen, Tao Zhao, Xianhua Xu   +6 more
wiley   +1 more source

Identification of the product of two oncogenic rearranged forms of the RET proto-oncogene in papillary thyroid carcinomas.

, 1992
In papillary thyroid carcinomas, we have identified two tumor-specific rearrangements of the RET proto-oncogene leading to the formation of different transforming fusion products sharing the tyrosine kinase (tk) domain of the proto-oncogene and ...
M. Grieco, SANTORO, MASSIMO, A. Migliazza, G. D. Porta, M. G. Borrello, F. Zunino, C. Lanzi, FUSCO, ALFREDO, R. A. Gambetta, I. Bongarzone   +9 more
core   +1 more source

Distribution of RET proto-oncogene variants in children with appendicitis [PDF]

Background: In addition to patient-related systemic factors directing the immune response, the pathomechanisms of appendicitis (AP) might also include insufficient drainage leading to inflammation caused by decreased peristalsis.
Fitze, Guido, Schultz, Jerek, Glatte, Patrick, Ziegler, Andreas, Freibothe, Ines, Görgens, Heike, Barreton, Gustavo, Haase, Michael   +7 more
core   +1 more source

Involvement of RET oncogene in human tumours: specificity of RET activation to thyroid tumours.

, 1993
Non-thyroid neoplasia were analysed by Southern blot of genomic DNA and DNA prepared by reverse transcription and amplification by polymerase chain reaction (RT/PCR) for the activation of the RET oncogene. It is known that the rearrangement of RET occurs
M. Grieco, M. Santoro, T. Ushijima, CARLOMAGNO, Francesca, M. L. Martelli, C. Paulin, N. Sabino, A. Cerrato, C. Battaglia, Y. Ishizaka   +9 more
core   +2 more sources

Expression of the ret Proto-oncogene in Human Medullary Thyroid Carcinomas and Pheochromocytomas of MEN 2A [PDF]

, 1992
We studied the expression of the ret proto-oncogene (proto-ret) in human medullary thyroid carcinomas (MTCs) and pheochromocytomas of multiple endocrine neoplasia type 2A (MEN 2A) by Northern blot analysis.
Yamamoto, Masayuki, Ishizaka, Yukihito, Karakawa, Katsu, Toyoshima, Kumao, Takai, Shin-Ichiro, Morimoto, Hideki, Mori, Takesada, Miya, Akihiro, Tanaka, Norifumi, Shin, Esei   +9 more
core   +1 more source

Multiple Endocrine Neoplasia type 2B and RET proto-oncogene.

, 2012
Multiple Endocrine Neoplasia type 2B (MEN 2B) is an autosomal dominant complex oncologic neurocristopathy including medullary thyroid carcinoma, pheochromocytoma, gastrointestinal disorders, marphanoid face, and mucosal multiple ganglioneuromas ...
Lombardi, L, Del Rossi Cg,, Lerone, M, Tonini, Gp, Bricco, L, MARTUCCIELLO, GIUSEPPE, Bernasconi, S.   +6 more
core   +1 more source

RET proto-oncogene and thyroid cancer [PDF]

, 2018
TheRET proto-oncogene has not only conclusively been identified as responsible for the three subtypes of the inherited cancer syndrome multiple endocrine neoplasia type 2 (MEN-2) but also shown to be involved in the molecular evolution of sporadic ...
Komminoth, Paul
core  

RET Proto-Oncogene Mutation in Medullary Thyroid Carcinoma

, 2002
Background: The molecular pathogenesis of hereditary medullary thyroid carcinoma is well known to be associated with germ-line mutation in the RET proto-oncogene and sporadic medullary thyroid carcinoma has been shown to carry somatic RET mutation ...
조남훈
core   +1 more source