Results 171 to 180 of about 31,892 (198)

To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway.

World J Gastrointest Oncol
Bao ZC, Liu ZD, Zhang Y, Dai HJ, Jia H, Ren F, Li N, Zhao L, Wang YW, Lv SY, Zhang Y.   +10 more
europepmc   +1 more source

Challenges and resistance mechanisms to EGFR targeted therapies in head and neck cancers and breast cancer: Insights into RTK dependent and independent mechanisms. [PDF]

Oncotarget
Shyamsunder S, Lu Z, Takiar V, Waltz SE.
europepmc   +1 more source

Dapagliflozin in Chronic Kidney Disease: Insights from Network Pharmacology and Molecular Docking Simulation. [PDF]

Life (Basel)
Phongphithakchai A, Tedasen A, Netphakdee R, Leelawattana R, Srithongkul T, Raksasuk S, Huang JC, Chatatikun M.   +7 more
europepmc   +1 more source

Differential Role of CD318 in Tumor Immunity Affecting Prognosis in Colorectal Cancer Compared to Other Adenocarcinomas. [PDF]

J Clin Med
Patel B, Curcic M, Eltokhy MA, Prasad S.
europepmc   +1 more source

Targeting Self-Binding Peptides as a Novel Strategy To Regulate Protein Activity and Function: A Case Study on the Proto-oncogene Tyrosine Protein Kinase c-Src

Journal of Chemical Information and Modeling, 2017
Previously, we have reported a new biomolecular phenomenon spanning between protein folding and binding, termed as self-binding peptides (SBPs), where a short peptide segment in monomeric protein functions as a molecular switch by dynamically binding to/unbinding from its cognate domain in the monomer (Yang et al. J. Chem. Inf.2015, 55, 329-342). Here,
Zhengya Bai, Shasha Hou, Shilei Zhang, Zhongyan Li, Peng Zhou   +4 more
openaire   +4 more sources

Cardiotoxin III suppresses the invasiveness of MDA-MB-231 cells by targeting proto-oncogene tyrosine-protein kinase Src and reversing mesenchymal-to-epithelial transition

Toxicological & Environmental Chemistry, 2016
ABSTRACTThe epithelial-to-mesenchymal transition is the first step required for breast cancer to initiate metastasis. The aberrant activation of proto-oncogene tyrosine-protein kinase Src regulates multiple functions during tumor progression. Cardiotoxin III, a basic polypeptide isolated from Naja naja atra venom, has been shown to exhibit anticancer ...
Long-Sen Chang, Yi-Ling Lin, Shinne-Ren Lin, Yaw-Syan Fu, Pei-Chien Tsai   +4 more
openaire   +3 more sources

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Trends in kinase drug discovery: targets, indications and inhibitor design

Nature Reviews Drug Discovery, 2021
Helgi B Schiöth, Misty M Attwood, Stefan Knapp   +2 more
exaly  

Kinase drug discovery 20 years after imatinib: progress and future directions

Nature Reviews Drug Discovery, 2021
Darren Cross, Pasi A Jänne, Philip Cohen   +2 more
exaly  

Kinase inhibition in autoimmunity and inflammation

Nature Reviews Drug Discovery, 2021
Ali A Zarrin, Bruno Hochhegger, Katherine Bao   +2 more
exaly