Pathological Mechanisms Involved in HIV-Associated Lymphomagenesis: Novel Targeted Therapeutic Approaches. [PDF]
CellsStraista M +4 more
europepmc +1 more source
EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer
Advanced Science, EarlyView.Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang +7 more
wiley +1 more source
The Simultaneous Treatment of PC-3 Cells with the DNA-Demethylating Agent Decitabine and S-Adenosylmethionine Leads to Synergistic Anticancer Effects. [PDF]
Genes (Basel)Schmidt T, Sticht C.
europepmc +1 more source
Advanced Science, EarlyView.FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song +17 more
wiley +1 more source
Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy
Aggregate, EarlyView.Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang +6 more
wiley +1 more source
Investigating the Role of Osteopontin (OPN) in the Progression of Breast, Prostate, Renal and Skin Cancers. [PDF]
BiomedicinesKundu G, Elangovan S.
europepmc +1 more source
Artificial Intelligences: A Bridge Toward Diverse Intelligence and Humanity's Future
Advanced Intelligent Systems, EarlyView.Many discussions of artificial intelligence fail to address deeper questions being raised by advances in developmental biology, neuroscience, bioengineering, and philosophy of mind. Novel beings, including technologically and biologically augmented humans, engineered life forms, hybrots, and others, require tools of the emerging field of diverse ...
Michael Levin
wiley +1 more source
Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC has increased worldwide in the last few decades, both in medullary and follicular‐derived subtypes. Several drugs, including multikinase and selective inhibitors, have been explored.
Sara Gil‐Bernabé +5 more
wiley +1 more source
Footprint-free induced pluripotent stem cells can be successfully differentiated into mesenchymal stromal cells in the feline model. [PDF]
Stem Cell Res TherWeeratunga P +3 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.BSN suppresses the cell viability of colorectal cancer by inducing GPX4‐regulated ferroptosis. BSN may bind to NRF2 protein to inactivate the NRF2 signaling, inhibiting the expression of p62 and HO‐1. Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties.
Shi‐Yuan Wen +5 more
wiley +1 more source