Results 41 to 50 of about 511 (225)

Alterity and Occidentalism in Fourteenth-Century Icelandic Texts: Narratives of Travel, Conversion, and Dehumanization [PDF]

, 2020
This article analyses five fourteenth-century Old Norse travel narratives in light of the learned geographical tradition of medieval Iceland. Three of the narratives, Þorvalds þáttr víðfǫrla, Eiríks saga víðfǫrla, and Yngvars saga víðfǫrla, focus on the ...
Vídalín, Arngrímur
core   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Aristotle’s Politics on Greeks and non-Greeks. [PDF]

, 2021
Scholars of race in antiquity commonly claim that Aristotle holds proto-racist views about βάρβαροι or non-Greeks. But a careful examination of Aristotle’s remarks in his Politics about slavery, non-Greek political institutions, and Greek and non-Greek ...
Lockwood, Thornton
core  

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

The Medieval Archive of Antisemitism in Nineteenth-Century Sweden [PDF]

This book is the first study of the development of antisemitism in nineteenth-century Sweden, based on an analysis of 150 books and pamphlets. The significance of religion for the development of modern racist antisemitism is a much debated topic – the ...
Heß, Cordelia
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

The Sin of Skin: Color and ‘Other’ in the Greco-Roman World [PDF]

, 2017
Many Scholars have denied the presence of racial categorizing in European Antiquity. Though there was no institutionalized system of ‘racial oppression’ like we are familiar with in today’s society, I contend that there are cultural precursors of ‘race ...
Gill, Grace
core   +1 more source

Génesis glotopolítica del raciolingüismo. El multilingüismo contemporáneo ante la construcción histórica del privilegio lingüístico [PDF]

, 2022
The article explores the historical bases of linguistic racism. The text locates proto-racism against Andalusia in al-Andalus as the origin of Andalusian discursive and social practices, fully consolidated from the 16th century to the present day.
Rodríguez-Iglesias, Ígor
core   +1 more source