Results 241 to 250 of about 7,398,890 (347)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Therapeutic hypothermia for newborns with hypoxic-ischaemic encephalopathy. [PDF]

open access: yesCochrane Database Syst Rev
Fink A   +11 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

EasyBOPT: A Digitally Standardized Protocol to Simplify and Reproduce the Biologically Oriented Preparation Technique (BOPT)-Technique Description and Case Series. [PDF]

open access: yesJ Clin Med
Agustín-Panadero R   +7 more
europepmc   +1 more source

Improved Energy-Based Efficient Routing Protocol for Underwater Wireless Sensor Networks

open access: diamond
S. Y. Barde   +5 more
openalex   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Sex-based physiological responses to a 750-m swim at critical velocity estimated by the three-parameter model. [PDF]

open access: yesClinics (Sao Paulo)
Souza VRDA   +7 more
europepmc   +1 more source

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