Results 91 to 100 of about 3,333,768 (293)
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Critiques protocolaires d’Internet : comparaison des projets IPFS et SecureScuttleButt
Tic & SociétéThis article highlights the political a priori and debates around two critical infrastructures proposed as alternatives to current Internet protocols: the IPFS (Interplanetary File System) and SSB (SecureScuttlebutt). Using critical discourse analysis to
Pierre DEPAZ
doaj +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Cluster-Based Load Balancing Algorithms for Grids
, 2011 E-science applications may require huge amounts of data and high processing power where grid infrastructures are very suitable for meeting these requirements. The load distribution in a grid may vary leading to the bottlenecks and overloaded sites.
Dagdeviren, Orhan +2 more
core
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
PLoS ONEProtocol registrationThis study protocol has been preregistered with the Open Science Framework (OSF) to enhance transparency, reproducibility, and methodological rigour.
Houda Al Kalaf +4 more
doaj +1 more source
Biological hazards that can affect the health of the workers that handle hospital waste
International Journal of Occupational and Environment Safety, 2019 Technological advances allow the science development, with the creation of new materials / equipment and the offer of different products and services. Some of these materials, after use, are discarded, becoming waste.
Trajano Felipe Barrabas Xavier da Silva +3 more
doaj +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source