Results 111 to 120 of about 3,341,855 (333)

The interrater and intrarater reliability of the flexibility and strength tests included in the Sport Science Lab® screening protocol amongst professional rugby players

, 2021
Candice MacMillan, Benita Olivier, Natalie Benjamin‐Damons   +2 more
openalex   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Systems thinking and complexity science methods and the policy process in non-communicable disease prevention: a systematic scoping review protocol [PDF]

, 2021
Chloe Clifford Astbury, Elizabeth McGill, Matt Egan, Tarra L. Penney   +3 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Characteristics of deep-sea microbial cellulases: key determinants of the ultimate fate of plant biomass on Earth

Journal of Wood Science
Land plants, especially those with significant woody biomass, represent the largest source of biomass on Earth, making the biodegradation of lignocellulosic materials critical to understanding the global carbon cycle.
Mikako Tachioka, Mikiko Tsudome, Miwako Tsuda, Satoshi Hiraoka, Masayuki Miyazaki, Yoshihiro Takaki, Shigeru Deguchi   +6 more
doaj   +1 more source

Implementation of Open Science Practices: Experience of the Vernadskyi National Library of Ukraine

University Library at a New Stage of Social Communications Development
Objective. The scientific publication aims to analyse the possibilities of integrating library collections into the open science infrastructure and demonstrate the achievements of the Vernadskyi National Library of Ukraine in this direction. Methods.
T. V. SYMONENKO, V. M. ZAYIKA
doaj   +1 more source

Conducting transformative research protocols in sports science

Frontiers in Sports and Active Living
This article presents a methodology for “fundamental field research” in sports science, from a transdisciplinary and transformative perspective. It is based on a close and symmetrical partnership between researchers and practitioners. The approach is structured around four detailed and illustrated methodological stages: (1) researchers develop an ...
Santi, Robin, Isserte, Simon, Gaudin, Cyrille, Chaliès, Sébastien   +3 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Implementation evaluation of staff support and wellbeing programmes at an academic health science centre during COVID-19: study protocol [PDF]

, 2021
Barbora Krausova, Sam Gnanapragasam, Len Demetriou, Alison Beck, Renata Pires-Yfantouda, Mary Docherty, Nick Sevdalis   +6 more
openalex   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source