Results 111 to 120 of about 6,745,951 (330)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

A Dynamic, Multi-Protocol Data Storage Integration Framework for Multi-Tenanted Science Gateway Middleware [PDF]

, 2021
Dimuthu Wannipurage, Suresh Marru, Eroma Abeysinghe, Isuru Ranawaka, Marcus Christie, Marlon Pierce   +5 more
openalex   +1 more source

A program to help students of life sciences prepare a research protocol

Research in Learning Technology, 2002
This paper describes a Web-based program that has been written in JavaScript to help honours-level students to design a protocol for their research project. It consists of several screens which contain text-input boxes and options, that students can select to determine what statistical test is appropriate.
openaire   +5 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

New quality and quantity indices in science (NewQIS): the study protocol of an international project [PDF]

, 2009
Beatrix Groneberg‐Kloft, Tanja C. Fischer, David Quarcoo, Cristian Scutaru   +3 more
openalex   +1 more source

Pedagogical Approaches and Learning Activities, Content, and Resources Used in the Design of Massive Open Online Courses (MOOCs) in the Health Sciences: Protocol for a Scoping Review (Preprint) [PDF]

, 2021
Øystein Røynesdal, Jeanette H. Magnus, Anne Moen   +2 more
openalex   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Detection of Exaggerated Blood Pressure Response Using Laboratory of Physical Science Protocol and Risk of Future Hypertension [PDF]

, 2010
Tsutomu Odahara, Masataka Irokawa, Hiroshi Karasawa, Shinya Matsuda   +3 more
openalex   +1 more source

How is resilience conceptualized and operationalized in occupational therapy and occupational science literature? Protocol for a scoping review [PDF]

, 2022
Justin Turner, William C. Miller, Holly Reid, Débora Petry Moecke, Stephanie Crosbie, Ivan Kamurasi, Mirha Girt, Maryke Peter, Polina Petlitsyna, Madeline Friesen, Jessica Towle, Alexandra Knox, Ashley Winter, Pat G. Camp   +13 more
openalex   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source