Results 121 to 130 of about 7,056,691 (346)

Implementation evaluation of staff support and wellbeing programmes at an academic health science centre during COVID-19: study protocol [PDF]

, 2021
Barbora Krausova, Sam Gnanapragasam, Len Demetriou, Alison Beck, Renata Pires-Yfantouda, Mary Docherty, Nick Sevdalis   +6 more
openalex   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Research Software vs. Research Data II: Protocols for Research Data dissemination and evaluation in the Open Science context

, 2022
Teresa Gomez-Diaz, Tomás Recio
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Implementation of Open Science Practices: Experience of the Vernadskyi National Library of Ukraine

University Library at a New Stage of Social Communications Development
Objective. The scientific publication aims to analyse the possibilities of integrating library collections into the open science infrastructure and demonstrate the achievements of the Vernadskyi National Library of Ukraine in this direction. Methods.
T. V. SYMONENKO, V. M. ZAYIKA
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Characteristics of deep-sea microbial cellulases: key determinants of the ultimate fate of plant biomass on Earth

Journal of Wood Science
Land plants, especially those with significant woody biomass, represent the largest source of biomass on Earth, making the biodegradation of lignocellulosic materials critical to understanding the global carbon cycle.
Mikako Tachioka, Mikiko Tsudome, Miwako Tsuda, Satoshi Hiraoka, Masayuki Miyazaki, Yoshihiro Takaki, Shigeru Deguchi   +6 more
doaj   +1 more source

Study protocol of EUREST-PLUS - European Regulatory Science on Tobacco: Policy Implementation to Reduce Lung Disease [PDF]

, 2018
Constantine Vardavas, Nicolas Bécuwe, Tibor Demjén, Esteve Fernández, Ann McNeill, Ute Mons, Yannis Tountas, Antigona Trofor, Aristides Tsatsakis, Gernot Rohde, Marc C. Willemsen, Krzysztof Przewoźniak, Witold Zatoński, Geoffrey T. Fong   +13 more
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Science Commons protocol for open data

, 2007
Announcing the Protocol for Implementing Open Access Data, Science Commons blog, December 16, 2007.  From the protocol itself: <strong> Comments </strong> This protocol is much needed and well conceived.  It&#39;s a very good sign that so many key stakeholders are already part of the process and support it.
openaire   +1 more source