Results 121 to 130 of about 6,745,951 (330)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Study protocol of “From Science 2 School”—prevalence of sports and physical exercise linked to omnivorous, vegetarian and vegan, diets among Austrian secondary schools [PDF]

open access: gold, 2022
Katharina Wirnitzer   +8 more
openalex   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Bridging behavior science and gaming theory: Using the Intervention Mapping Protocol to design a serious game against cyberbullying [PDF]

open access: green, 2015
Ann DeSmet   +10 more
openalex   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

A mixed-methods study on the design of Artificial Intelligence and data science-based strategies to inform public health responses to COVID-19 in different local health ecosystems: A study protocol for COLEV [PDF]

open access: gold, 2022
Catalina González-Uribe   +12 more
openalex   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Open Science Practices in Integrated Assessment Models [version 2; peer review: 2 approved, 1 approved with reservations]

open access: yesOpen Research Europe
Background Open science emphasizes the free and accessible dissemination of scholarly outputs to a wide audience, including scientists, stakeholders, and the general public. Its core principle is the open sharing of knowledge to enable reuse, replication,
Jon Sampedro   +4 more
doaj  

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