Results 171 to 180 of about 7,056,691 (346)

How has the philosophy of pragmatism been addressed in occupational therapy and occupational science? Protocol for a scoping review

open access: gold
Naila Pereira Souza   +4 more
openalex   +1 more source

Yale Program for Psychedelic Science (YPPS) Manual for Psilocybin-OCD Session Monitors for Protocol HIC: 2000020355

open access: gold, 2022
Terence H. W. Ching   +4 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Informationally complete distributed metrology without a shared reference frame. [PDF]

open access: yesNat Commun
Xu HQ   +8 more
europepmc   +1 more source

More on the Science Commons open data protocol

open access: yes, 2008
Thinh Nguyen, Freedom to Research: Keeping Scientific Data Open, Accessible, and Interoperable, <em> Science Commons </em> , April 23, 2008.  (Thanks to the Science Commons blog.)  Nguyen is the Counsel for Science Commons.
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Protocol, mainstreaming Open Science

open access: yes
Protocol for baselining and bestpractice assessment of Mainstreaming Open Science ...
openaire   +1 more source

MOUSS protocol for the Pacific Islands Fisheries Science Center

open access: green, 2020
Dianna R. Miller-Greene   +2 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

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