Results 191 to 200 of about 3,341,855 (333)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

On the prior use of high-fidelity simulation to improve clinical trial development and implementation. [PDF]

J Clin Transl Sci
Taekman J.
europepmc   +1 more source

Social Science Protocols

, 2018
openaire   +1 more source

Peer Review Report For: Tracking the Evolving Role of Artificial Intelligence in Implementation Science: Protocol for a Living Scoping Review of Applications, Evaluation Approaches and Outcomes [version 2; peer review: 2 approved]

James L David
openalex   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Surgical Induction of Mid-Thoracic Aortic Coarctation in Mice: A Reproducible Preclinical Model of Pressure-Induced Vascular Remodeling. [PDF]

Curr Protoc
Lauver DA, Garver H, Kreiger-Burke T, Rendón CJ, Contreras GA, Watts SW, Fink GD.   +6 more
europepmc   +1 more source

Additional file 1 of Bridging Indigenous and science-based knowledge in coastal-marine research, monitoring, and management in Canada: a systematic map protocol

, 2019
Steven M. Alexander, Jennifer F. Provencher, Dominique Henri, Jessica J. Taylor, Steven J. Cooke   +4 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Protocol for biomass and carbon storage estimation in tropical rainforests via remote sensing imagery. [PDF]

STAR Protoc
Ngo DT, Nguyen HD, Viet Nguyen HH, Dang NT, Gorbunov R, Pham NC.   +5 more
europepmc   +1 more source

Executive Agreements Database, Statement Regarding Agreement To Amend and Extend The Protocol On Cooperation In The Field Of Marine and Fishery Science and Technology Between The United States and China Signed At Beijing July 21, 2004

, 2020
Oona A. Hathaway, Curtis A. Bradley, Jack L. Goldsmith   +2 more
openalex   +1 more source