Results 201 to 210 of about 8,627,478 (377)

Tetrafluoroisopropylation of alkenes and alkynes enabled by photocatalytic consecutive difluoromethylation with CF2HSO2Na

Nature Communications
Direct assembly of complex fluorinated motifs from simple fluorine sources is an attractive frontier of synthetic chemistry. Reported herein is an unconventional protocol for achieving tetrafluoroisopropylation by using commercially available CF2HSO2Na ...
Yuwei Hong, Jiayan Qiu, Zhenzhen Wu, Sangxuan Xu, Hanliang Zheng, Gangguo Zhu   +5 more
doaj   +1 more source

Using behavioural science to enhance use of core outcome sets in trials: protocol [PDF]

, 2023
Karen Matvienko‐Sikar, Molly Byrne, Mike Clarke, Jamie J Kirkham, Jan Kottner, Katie Mellor, Fiona Quirke, Ian J. Saldanha, Valerie Smith, Elaine Toomey, Paula Williamson   +10 more
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Selection Protocol for Replication in Sports and Exercise Science

, 2021
Jennifer Murphy, Cristian Mesquida, Aaron R. Caldwell, Brian D. Earp, Joe Warne   +4 more
openalex   +1 more source

Optimising scale-up for public health impact: a multimethod implementation science research protocol to improve infant health outcomes in Ethiopia [PDF]

, 2023
Dieudonne Hakizimana, Kegnie Shitu, Katherine C Rankin, Getahun Asres Alemie, Judd L. Walson, Brandon L. Guthrie, Arianna Rubin Means   +6 more
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Perspective: leveraging review protocols to advance implementation science in support of older adults’ health equity

Frontiers in Public Health
Globally, there has been an increasing call for dissemination and implementation science to improve the health equity of older adults. However, improving the health equity of older adults requires methods that allow for an in-depth understanding of the ...
Juanita-Dawne Bacsu, Avery Pottle, Florriann Fehr, Megan Funk, Matthew Lee Smith   +4 more
doaj   +1 more source

Effectiveness of Vachadi Ointment in the management of Pama Kushta (Scabies): A Novel Research Protocol Using Science of Ayurveda

, 2021
Rakesh Khatana, Renu Rathi, P Scholar
openalex   +2 more sources

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Governance and responses of health and surveillance systems to COVID-19 in BRICS countries: A scoping review protocol.

PLoS ONE
RegistrationThis protocol is registered on the Open Science Framework (OSF) (available at https://doi.org/10.17605/OSF.IO/SN5ZY) and Figshare (available at https://doi.org/10.6084/m9.figshare.25908340) platforms.
Adelyne Maria Mendes Pereira, Monique Azevedo Esperidião, Sílvia Karla Azevedo Vieira Andrade, João Felipe Marques Silva, Louise Celeste Rolim Silva, Adriano Silva, Isabela Barboza da Silva Tavares Amaral, Isabel Domingos Martinez Dos Santos, Thalyta Cássia de Freitas Martins, Aline Degrave   +9 more
doaj   +1 more source