Results 231 to 240 of about 3,364,671 (289)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

FOCU.SE trial: a nationwide Swedish drug repurposing protocol and research framework. [PDF]

Acta Oncol
Abel E, Östling P, Hallersjö Hult E, Kulbacka K, Babacic H, Baan A, Carneiro A, De Petris L, Fagman H, Friesland S, Frisell O, Hellström M, Lindahl G, Steen Carlsson K, Tamborero D, Valachis A, Öhlund D, Lehtiö J, Rosenquist R, Edsjö A, FOCU.SE trial group.   +20 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Older adults as active research partners: protocol for an umbrella review. [PDF]

BMJ Open
Hedqvist AT, Strandberg S, Holmberg B, Niklasson J, Violasdotter Nilsson P, Carlsson W, Andreassen M, Bergstrand S, Holmberg M, Nilsen C.   +9 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Correction: ISCEV extended protocol for the photoreceptor directed ERG using full-field silent substitution stimuli. [PDF]

Doc Ophthalmol
Kremers J, Barboni MTS, Zele AJ, Feigl B, McAnany JJ, Robson AG, Nagy BV, Parry N, Mahroo OA, Huchzermeyer C.   +9 more
europepmc   +1 more source

The Role of Artificial Intelligence and Professional Expertise in Adapted Physical Activity Prescription for Orthopedic Rehabilitation. [PDF]

J Funct Morphol Kinesiol
Sortino M, Trovato B, Chiaramonte R, Carrera A, Sapienza M, Roggio F, Musumeci G.   +6 more
europepmc   +1 more source

Implementation of a Direct Oral Anticoagulants Interruption Protocol. [PDF]

TH Open
Gimelfarb D, Ghorbanzadeh A, Tafur AJ.
europepmc   +1 more source

Protocol for isolating plant-derived extracellular vesicles. [PDF]

STAR Protoc
Chen Y, Xu L, Yu Y, Xu Z, Xiao S, Mai H.
europepmc   +1 more source

Protocol update to: Protocol to generate dual-target compounds using a transformer-based chemical language model. [PDF]

STAR Protoc
Srinivasan S, Bajorath J.
europepmc   +1 more source