Results 271 to 280 of about 3,341,855 (333)

Stimulation methods for collecting urine from hospitalised precontinent infants: study protocol for a prospective, multicentre, open-label, three-arm, parallel-group randomised controlled trial. [PDF]

BMJ Open
Li F, Yuan C, Cao F, Feng P, Li S, Xiang L, Hu Q, Feng L, Wang C, Bao P, Zhang M, Mei L, Li J, Cheng Y, Zheng Z, Huang W.   +15 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Feasibility of shortening the ¹⁸F-FDG Patlak scan time in a high-sensitivity short-axial field-of-view positron emission tomography-computed tomography system for oncological studies using deep learning denoising algorithms. [PDF]

Quant Imaging Med Surg
Wang L, Zhang S, Yang S, Ma R, Li H, Liu J, Gao J, Wei Y, Fu L.   +8 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Effect of social and digital media mental health messaging on mental health help-seeking behaviors in the sub-Saharan African population: A systematic review protocol. [PDF]

PLoS One
Boateng PA, Osei Duah Junior I, Ampong J, Dowuona-Hammond M, Schulz PJ, Marciano L.   +5 more
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Evaluation of Reduced Single-Photon Emission Computed Tomography Imaging Protocols and Software Variability in ¹⁷⁷Lu-DOTATATE Dosimetry: Protocol for an Exploratory Observational Trial.

JMIR Res Protoc
Yagihashi T, Miwa K, Miyaji N, Sugimoto S, Hayakawa H, Kobayashi N, Takano S, Murai T.   +7 more
europepmc   +1 more source

Petit volunteer protocol for loneliness alleviation in community-dwelling older adults in Japan: a randomised controlled trial. [PDF]

BMJ Open
Tomida K, Shimoda T, Nakajima C, Kawakami A, Shimada H.   +4 more
europepmc   +1 more source