Results 71 to 80 of about 6,953,213 (308)

The inhibitory SAPS3–AMPK interaction detected in HEK293 cells is not detectable in muscle or liver from humans or mice

FEBS Letters, EarlyView.
This study challenges the idea that Sit4‐associated protein subunit 3 (SAPS3) inhibits the energy‐sensing enzyme AMP‐activated protein kinase (AMPK) in muscle and liver tissue. Although SAPS3 interacts with AMPK in cultured cells, we found no such interaction in human or mouse tissues subjected to fasting, exercise, or a high‐fat diet.
Jesper B. Birk, Maria A. Møller, Jørgen F.P. Wojtaszewski, Rasmus Kjøbsted   +3 more
wiley   +1 more source

Translating knowledge into action for child obesity treatment in partnership with Parks and Recreation: study protocol for a hybrid type II trial

Implementation Science, 2023
Background Safe and effective treatment exists for childhood obesity, but treatment recommendations have largely not been translated into practice, particularly among racial and ethnic minorities and low-wealth populations.
Cody D. Neshteruk, Asheley C. Skinner, Julie Counts, Emily M. D’Agostino, Leah Frerichs, Janna Howard, Mary Story, Sarah C. Armstrong   +7 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

A systematic review of protocol studies on conceptual design cognition: Design as search and exploration

Design Science, 2017
This paper reports findings from the first systematic review of protocol studies focusing specifically on conceptual design cognition, aiming to answer the following research question: What is our current understanding of the cognitive processes involved
L. Hay, A. Duffy, C. McTeague, Laura M Pidgeon, T. Vuletic, M. Grealy   +5 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Updating the critical steps of the quality implementation framework: a protocol for an umbrella review of reviews

BMJ Open
Introduction Implementation science focuses on improving the dissemination, uptake and adoption of evidence into practice. Over the last decade, implementation science research has proliferated, particularly in healthcare and social science.
Jeffrey Braithwaite, Louise A Ellis, Søren Paaske Johnsen, Kathrine Hald, Julie Midtgaard, Anne Gulbech Ording, Lisa Pagano, Georgia Fisher, Samantha Spanos, Martin Jorsal   +9 more
doaj   +1 more source

Protocol for the treatment of patients with a spectrum of opiomyelitis-associated diseases using bone marrow stromal cells in the State Institution "Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine" [PDF]

, 2022
Natalia Voloshyna, Vitalii Vasylovskyi, Maksym Chernenko   +2 more
openalex   +1 more source

C4MIP – The Coupled Climate–Carbon Cycle Model Intercomparison Project: Experimental protocol for CMIP6

, 2016
. Coordinated experimental design and implementation has become a cornerstone of global climate modelling. Model Intercomparison Projects (MIPs) enable systematic and robust analysis of results across many models, by reducing the influence of ad hoc ...
C. Jones, V. Arora, P. Friedlingstein, L. Bopp, V. Brovkin, J. Dunne, H. Graven, F. Hoffman, T. Ilyina, J. John, M. Jung, M. Kawamiya, C. Koven, J. Pongratz, T. Raddatz, J. Randerson, S. Zaehle   +16 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Strengthening health systems response to violence against women: protocol to test approaches to train health workers in India

Pilot and Feasibility Studies, 2020
Background Globally, including in low- and middle-income [LMIC] countries, there is increased attention to and investment in interventions to prevent and respond to violence against women; however, most of these approaches are delivered outside of formal
Sarah R. Meyer, Sangeeta Rege, Prachi Avalaskar, Padma Deosthali, Claudia García-Moreno, Avni Amin   +5 more
doaj   +1 more source