Results 71 to 80 of about 6,745,951 (330)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Defining the biomethane potential (BMP) of solid organic wastes and energy crops: a proposed protocol for batch assays.

Water Science and Technology, 2009
The application of anaerobic digestion technology is growing worldwide because of its economic and environmental benefits. As a consequence, a number of studies and research activities dealing with the determination of the biogas potential of solid ...
I. Angelidaki, M. Alves, D. Bolzonella, L. Borzacconi, J. L. Campos, A. Guwy, S. Kalyuzhnyi, P. Jeníček, J. Lier   +8 more
semanticscholar   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

A survey of researchers’ methods sharing practices and priorities [PDF]

PeerJ
Missing or inaccessible information about the methods used in scientific research slows the pace of discovery and hampers reproducibility. Yet little is known about how, why, and under what conditions researchers share detailed methods information, or ...
Marcel LaFlamme, James Harney, Iain Hrynaszkiewicz   +2 more
doaj   +2 more sources

The European Stag Beetle (Lucanus cervus) Monitoring Network: International Citizen Science Cooperation Reveals Regional Differences in Phenology and Temperature Response

Insects, 2021
To address the decline in biodiversity, international cooperation in monitoring of threatened species is needed. Citizen science can play a crucial role in achieving this challenging goal, but most citizen science projects have been established at ...
Arno Thomaes, Sylvie Barbalat, Marco Bardiani, Laura Bower, Alessandro Campanaro, Natalia Fanega Sleziak, João Gonçalo Soutinho, Sanne Govaert, Deborah Harvey, Colin Hawes, Marcin Kadej, Marcos Méndez, Bruno Meriguet, Markus Rink, Sarah Rossi De Gasperis, Sanne Ruyts, Lucija Šerić Jelaska, John Smit, Adrian Smolis, Eduard Snegin, Arianna Tagliani, Al Vrezec   +21 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

MicroMundo Upside Down: Targeted Searching for Antibiotics-Producing Bacteria From Soil With Reverse Antibiosis Approaches

Frontiers in Microbiology, 2020
Tiny Earth (TE) is a popular international citizen science program aimed at improving public awareness on the growing antimicrobial resistance problem of which MicroMundo Albacete is a Spanish node.
María Alvarado, María Alvarado, Pilar Clemente-Casares, Pilar Clemente-Casares, Diego A. Moreno, Diego A. Moreno, Piet W. J. de Groot, Piet W. J. de Groot, Piet W. J. de Groot, Piet W. J. de Groot   +9 more
doaj   +1 more source

Dearomative triple elementalization of quinolines driven by visible light

Nature Communications, 2023
Organoboron and organosilicon compounds have potential applications in various fields including materials science and medicinal chemistry. Here the authors report a protocol that enables the dearomative carbo-sila-boration of quinolines.
Shiho Ishigaki, Yuki Nagashima, Daiki Yukimori, Jin Tanaka, Takashi Matsumoto, Kazunori Miyamoto, Masanobu Uchiyama, Ken Tanaka   +7 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source