Results 81 to 90 of about 6,953,213 (308)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Women in Science: Where We Stand?—The WHEN Protocol

Education Sciences
Gender disparity in scientific fields, identified with the acronym STEM, is a complex issue whose multiple causes have distant origins in time.
Francesca Arnaboldi, Alessia Macagno, Marialuisa Villani, Giacomo Biganzoli, Francesca Bianchi   +4 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Protocol to Manage Heritage-Building Interventions Using Heritage Building Information Modelling (HBIM)

, 2018
The workflow in historic architecture projects presents problems related to the lack of clarity of processes, dispersion of information and the use of outdated tools.
Isabel Jordan-Palomar, P. Tzortzopoulos, J. García-Valldecabres, E. Pellicer   +3 more
semanticscholar   +1 more source

THE DEVELOPMENT OF THE KOREAN TEACHING OBSERVATION PROTOCOL (KTOP) FOR IMPROVING SCIENCE TEACHING AND LEARNING

Journal of Baltic Science Education, 2014
An observational instrument called the KTOP (Korean Teaching Observation Protocol) was developed to analyze science teaching and to identify the components of teaching that need improvement.
Jongwon Park, Young-Shin Park, Young-min Kim, Jongseok Park, Jin-Su Jeong   +4 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

An updated protocol for a systematic review of implementation-related measures

Systematic Reviews, 2018
BackgroundImplementation science is the study of strategies used to integrate evidence-based practices into real-world settings (Eccles and Mittman, Implement Sci. 1(1):1, 2006).
C. Lewis, Kayne D. Mettert, Caitlin N. Dorsey, Ruben G. Martinez, B. Weiner, Elspeth A Nolen, Cameo F. Stanick, Heather M. Halko, B. Powell   +8 more
semanticscholar   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Critiques protocolaires d’Internet : comparaison des projets IPFS et SecureScuttleButt

Tic & Société
This article highlights the political a priori and debates around two critical infrastructures proposed as alternatives to current Internet protocols: the IPFS (Interplanetary File System) and SSB (SecureScuttlebutt). Using critical discourse analysis to
Pierre DEPAZ
doaj   +1 more source

Biological hazards that can affect the health of the workers that handle hospital waste

International Journal of Occupational and Environment Safety, 2019
Technological advances allow the science development, with the creation of new materials / equipment and the offer of different products and services. Some of these materials, after use, are discarded, becoming waste.
Trajano Felipe Barrabas Xavier da Silva, Humberto Costa, Marcelo Ribeiro, Joana Guedes   +3 more
doaj   +1 more source