Results 51 to 60 of about 3,912 (301)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
One-particle spectral densities and phase diagrams of one-dimensional proton conductors
Condensed Matter Physics, 2021 The equilibrium states of one-dimensional proton conductors in the systems with hydrogen bonds are investigated. Our extended hard-core boson lattice model includes short-range interactions between hydrogen ions, their transfer along the hydrogen bonds ...
R. Ya. Stetsiv
doaj +1 more source
Proton Dynamics and Structural Modifications in the Protonic Conductor Perovskites [PDF]
Journal of the Physical Society of Japan, 2010 Quasi-elastic neutron scattering, neutron diffraction as well as in situ and ex situ Raman studies were performed on the proton conducting (Ba/Sr)Zr 1- x Ln x O 3-δ dense ceramics. The results confirm the homogeneous distribution of the bulk protonic species, their variable content as a function of Ln content and sample processing as well as successive
Colomban, P. +7 more
openaire +1 more source
Chitosan-based biopolysaccharide proton conductors for synaptic transistors on paper substrates [PDF]
, 2014 Chitosan is a natural biopolymer and has been widely used for bio- and medical-materials. In this letter, with protonic acid doping, chitosan-based biopolysaccharide proton conductors were prepared with a high proton conductivity of 6 x 10(-3) S cm(-1 ...
Zhang, Jin +4 more
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H/D isotope effects in high temperature proton conductors [PDF]
, 2015 The atomic mass ratio of ca. 2 between deuterium and hydrogen is the highest for any pair of stable isotopes and results in significant and measurable H/D isotope effects in high temperature proton conductors containing these species.
Poulsen, Finn Willy +5 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Tuning anhydrous proton conduction in single-ion polymers by crystalline ion channels
Nature Communications, 2018 High-conductivity solid-state electrolyte materials with minimal polarization loss are difficult to synthesize. Here the authors show single-ion block copolymers with crystalline protogenic channels having a promising potential to be used as efficient ...
Onnuri Kim +3 more
doaj +1 more source
Proton conductivity in BCY20-Pd ionic hybrid material in solid state proton conductors [PDF]
, 2011 1
Nigel Mark Sammes
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