Results 251 to 260 of about 5,053,091 (357)

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source

Commissioning of a 142.4 MeV ultra-high dose rate (UHDR) proton beamline in a synchrotron-based proton therapy system. [PDF]

Med Phys
Yin L, Sforza D, Miles D, Masumi U, Ota K, Jia X, Li H.   +6 more
europepmc   +1 more source

Proton therapy.

RADIOISOTOPES, 1989
openaire   +3 more sources

UV‐Triggered Cascading Degradation of Silicone Elastomer via Self‐Fluoride Amplification

Advanced Science, EarlyView.
UV‐triggered degradable materials offer proficient control of functional lifetime, while having issues with trigger efficiency. This work enhances the UV‐triggered degradation mechanism of silicone elastomer by introducing the UV‐initiated synergetic fluoride self‐amplification. The silicone composite shows excellent mechanical properties and on‐demand
Yoon‐Nam Kim, Woojin Jeon, Min‐Ha Oh, Hee‐June Seo, Min Sang Kwon, Seung‐Kyun Kang   +5 more
wiley   +1 more source

Instantaneous in vivo distal edge verification in intensity-modulated proton therapy by means of PET imaging. [PDF]

Med Phys
Zapien-Campos B, Ahmadi Ganjeh Z, Perotti-Bernardini G, Free J, Both S, Dendooven P.   +5 more
europepmc   +1 more source

Dual‐Targeted Nanovesicles Induced Cancer Stem‐Like Cell Differentiation to Sensitize Hepatocellular Carcinoma Radiotherapy

Advanced Science, EarlyView.
The existence of Pin1 and Notch1 crosstalk is identified and verified in HCC, and the crucial function of this crosstalk in sustaining the aggressive phenotypes of CSCs and radioresistance. A biomimetic nanovesicle is now developed to block the crosstalk between Pin1 and Notch1 for inducing CSCs differentiation and sensitizing HCC radiotherapy ...
Hongmei Cao, Qian Wang, Yanan Niu, Shuxiang Wang, Haixue Jia, Dianyu Wang, Jinjian Liu, Wei Yuan, Lijun Yang, Jianfeng Liu   +9 more
wiley   +1 more source

Estimates of cardiac implanted electronic device neutron dose for a pencil beam scanning proton therapy system. [PDF]

Med Phys
Hopfensperger KM, Li W, Sheldon SH, Rotondo RL, Chen RC, James SS, Lin Y.   +6 more
europepmc   +1 more source

Tumor Control in RG2 Glioma-Bearing Rats: A Comparison Between Proton Minibeam Therapy and Standard Proton Therapy.

International Journal of Radiation Oncology, Biology, Physics, 2019
Y. Prezado, G. Jouvion, C. Guardiola, W. González, M. Juchaux, J. Bergs, C. Nauraye, D. Labiod, L. de Marzi, F. Pouzoulet, A. Patriarca, R. Dendale   +11 more
semanticscholar   +1 more source

Capsaicin Alleviates Autophagy‐Lysosomal Dysfunction via PPARA‐Mediated V‐ATPase Subunit ATP6V0E1 Signaling in 3xTg‐AD Mice

Advanced Science, EarlyView.
Capsaicin enhances lipid metabolism, reduces lipid deposition, and alleviates AD‐related pathologies. Capsaicin activates PPARA, promoting the expression of PPAR signaling pathway‐related genes and accelerating lipid metabolism. Capsaicin upregulates ATP6V0E1‐V‐ATPase‐mediated lysosomal acidification, enhancing lipid droplet clearance. PPARA is the key
Haitao Yu, Jia Chen, Fangzhou Wang, Dongdong Jia, Shuguang Bi, Yuming Mao, Yu‐qi Zhang, Tian‐long Gao, Liu Yang, Jia‐xu Du, Zi‐han Zhou, Xi‐Chen Zhu, Gao‐shang Chai   +12 more
wiley   +1 more source