Results 291 to 300 of about 5,021,050 (358)

A Unique THN Motif Is Critical for Enabling Efficient C‐Terminal Traceless Cleavage

Advanced Science, EarlyView.
THN is identified as the key motif to facilitate the rapid traceless cleavage of gp41‐1. The deflection of THN motif not only avoids the interaction between C‐exteins and active sites, but also separates Asp107 away from Asn125. In addition, a flexible block F contributes to faster C‐cleavage.
Ruocheng Gu, Yunuo Lin, Rouyu Di, Tongtong Zhou, Tingwen Fan, Wei Li, Lili Miao, Huaiyi Yang   +7 more
wiley   +1 more source

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

Advanced Science, EarlyView.
Doxorubicin‐induced cardiomyopathy involves mitochondrial energy metabolism dysfunction, exacerbated by cardiomyocyte‐specific Slc25a49 deficiency via oxidative phosphorylation (OXPHOS) suppression and glycolysis activation. The Slc25a49–glucose‐6‐phosphate (G6P)–activator protein‐1 (AP‐1) axis drives myocardial injury by upregulating Sln, disrupting ...
Sitong Wan, Jingyi Qi, Yi Xia, Chang Fan, Teng Xu, Xu Zhang, Jiaxin Shi, Chenxuan Wang, Yitong Cheng, Dongyuan Zhang, Rong Liu, Yinhua Zhu, Changchang Cao, Dekui Jin, Peng An, Yongting Luo, Junjie Luo   +16 more
wiley   +1 more source

Manganese‐Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides

Advanced Science, EarlyView.
A Mn(II)‐catalyzed electrochemical method achieves site‐selective diazidation of dehydroalanine peptides with NaN₃. This radical relay process tolerates diverse functional groups, delivers high yields, and enables precise peptide modification, offering a powerful tool for bioconjugation and therapeutic development.
Xinwei Hu, Chengwei Zheng, Xiaotong Song, Balati Hasimujiang, Mu Chen, Zhixiong Ruan   +5 more
wiley   +1 more source

Ecofriendly Sunlight‐Mediated Nontoxic Bimetallic Nanoparticles: Synthesis, Reusable Catalytic Membrane, and Biosensor Applications

Advanced Science, EarlyView.
A novel sunlight‐driven synthesis produces Ag–Cu bimetallic nanoparticles (NPs) in just 10 min using nontoxic surfactants. These high‐quality NPs show excellent catalytic activity, functioning as reusable polytetrafluoroethylene (PTFE) and activated carbon fiber (ACF) supported catalysts for efficient conversion of p‐nitrophenol to p‐aminophenol, and ...
Samy M. Shaban, Sihyeok Kim, N. M. El Basiony, Jincymol Kappen, Mohamed H. Mostafa, Ahmed Y. Elbalaawy, Mohamed R. Elmasry, Jihoon Shin, Il Jeon, Dong‐Hwan Kim   +9 more
wiley   +1 more source

m6A‐Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT

Advanced Science, EarlyView.
TMCO3 as a downstream target of ALKBH5 is found, which regulates its expression in an m6A‐dependent manner, and then a new phosphorylation site on TMCO3 is identified and determines the specific mechanism of TMCO3 with AKT. Moreover, the combined treatment of targeting the TMCO3 and inhibition of AKT in mice models with HCC achieves great results ...
Xinxin Li, Mengzhen Han, He Zhu, Yonglong Pan, Chen Su, Yachong Liu, Zhibin Liao, Bixiang Zhang, Xiaoping Chen   +8 more
wiley   +1 more source

Tβ4‐Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing

Advanced Science, EarlyView.
A separable microneedle patch is designed for Tβ4–modified ADSC‐derived extracellular vesicles delivery. The overexpressed Tβ4 released from the microneedles can mitigate cellular senescence and promote wound healing via the PTEN/PI3K/AKT pathway, offering a promising approach for diabetic wound treatment. This bioengineered therapeutic system serve as
Youjun Ding, Jinglin Wang, Jiaye Li, Yi Cheng, Shuyin Zhou, Yepeng Zhang, Yuanjin Zhao, Min Zhou   +7 more
wiley   +1 more source

Exploring the Bioengineering Potential of CoFe2O4‐BaTiO3 Nanoparticles: A Dive into the Magnetoelectric Coefficient

Advanced Electronic Materials, EarlyView.
Magnetoelectric (ME) core–shell nanoparticles, particularly made of CoFe2O4‐BaTiO3, are emerging as promising materials for bioengineering applications. This perspective explores the evolution of measurement methodologies for their ME coefficient (α), highlighting variations in reported values.
Martina Lenzuni, Alessandra Marrella, Emma Chiaramello, Giulia Suarato, Paolo Ravazzani   +4 more
wiley   +1 more source

Ultrafine‐Mn‐Loaded N,O‐Doped Nanocarbon via Mott‒Schottky Effect for Photo‐Enhanced Antibacterial Therapy and Wound Healing

Aggregate, EarlyView.
Herein, we used the Mott–Schottky effect to synthesize an ultrafine‐Mn‐loaded N,O‐doped porous nanocarbons (Mn‐PNCs) nanozyme. The fabricated Mn‐PNCs nanozyme using a sustainable and efficient heteroatom‐doped strategy exhibited excellent photothermal‐enhanced, peroxidase‐like activity, thereby contributing to effective antibacterial treatment for ...
Xueyu Jiang, Fanwei Zeng, Yan Li, Yang Yi, Xiaodong Tang, Ang Lu   +5 more
wiley   +1 more source

Multifunctional Biomimetic Nanotherapeutics for Anti‐Oxidative and Anti‐Inflammatory Synergistic Therapy of Corneal Neovascularization

Aggregate, EarlyView.
An anti‐inflammatory and antioxidant metal‐organic framework (MOF) nanoplatform was prepared via one‐pot self‐assembly. In vitro and in vivo studies demonstrated that the prepared MVPC nanoparticles can effectively scavenge overproduced reactive oxygen species at diseased sites, enhance IL‐10 secretion, and suppress VEGFA expression, offering a novel ...
Shundong Cai, Mengdie Li, Jinfa Ye, Mingyou Zhang, Jingbin Zhuang, Yuhang Cheng, Hongjin Li, Lang Ke, Xingyuan Wei, Yun Han, Huanhuan Liu, Gang Liu, Chengchao Chu   +12 more
wiley   +1 more source

Mechanism of Cationic Peptide‐Induced Assembly of Gold Nanoparticles: Modulation of Electrostatic Repulsion

Aggregate, EarlyView.
Cationic peptides aggregate citrate‐capped gold nanoparticles (AuNPs), producing a colorimetric change. The figure highlights the interplay between the intermolecular attractive and repulsive forces governing the colloidal stability of the nanoparticles.
Benjamin Lam, Robert Ramji, Margaret Mullooly, Kristina D. Closser, Tod A. Pascal, Jesse V. Jokerst   +5 more
wiley   +1 more source