Results 41 to 50 of about 249,684 (338)

On the accuracy of Monte Carlo based beam dynamics models for the degrader in proton therapy facilities

, 2018
In a cyclotron-based proton therapy facility, the energy changes are performed by means of a degrader of variable thickness. The interaction of the proton beam with the degrader creates energy tails and increases the beam emittance.
Adelmann, A., Baumgarten, C., Meer, D., Rizzoglio, V., Snuverink, J., Talanov, V.   +5 more
core   +1 more source

Nuclear Emulsion Film Detectors for Proton Radiography: Design and Test of the First Prototype

, 2009
Proton therapy is nowadays becoming a wide spread clinical practice in cancer therapy and sophisticated treatment planning systems are routinely used to exploit at best the ballistic properties of charged particles.
Braccini, Saverio, Ereditato, Antonio, et al.,, Kreslo, Igor, Moser, Urs, Pistillo, Ciro, Scampoli, Paola, Studer, Simone   +7 more
core   +1 more source

Towards 3D printed multifunctional immobilization for proton therapy: initial materials characterization [PDF]

, 2016
Purpose: 3D printing technology is investigated for the purpose of patient immobilization during proton therapy. It potentially enables a merge of patient immobilization, bolus range shifting, and other functions into one single patient-speci c structure.
Ahn, American Society for Testing and Materials, Antoine D’Hollander, Attix, Barker, Barten, Bazalova, Crijns, Edmond Sterpin, Engelsman, Georg, Gottschalk, Guozhi Zhang, Hünemohr, Hünemohr, Jean-Marc Denis, Johns, Ju, Karin Haustermans, Kenneth Poels, Landry, Langendijk, Lindsay, Lomax, Lomax, Mathias Kersemans, Matsumoto, Mayer, Melchels, Nicolas Lammens, Palta, Ramaekers, Rutherford, Safai, Saito, Sandra Nuyts, Schneider, Seltzer, Sisterson, Steven Michiels, Titt, Tom Depuydt, Zhang, Zhao, Zou   +44 more
core   +2 more sources

First-in-human trial using mixed-reality visualization for patient setup during breast or chest wall radiotherapy

Radiation Oncology
Background The purpose of this study is to assess the feasibility of mixed-reality (MixR) visualization for patient setup in breast and chest wall radiotherapy (RT) by performing a first-in-human clinical trial comparing MixR with a 3-point alignment ...
Perry B. Johnson, Julie Bradley, Samsun Lampotang, Amanda Jackson, David Lizdas, William Johnson, Eric Brooks, Raymond B. Mailhot Vega, Nancy Mendenhall   +8 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Radiation Therapy Medical Physics Review – Delivery, Interactions, Safety, Feasibility, and Head to Head Comparisons of the Leading Radiation Therapy Techniques [PDF]

, 2017
Radiation therapy uses high energy radiation to kill cancer cells. Radiation therapy for cancer treatment can take the form of photon therapy (using x-rays and gamma rays), or charged particle therapy including proton therapy and electron therapy. Within
Collins, Cielle
core   +1 more source

Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver [PDF]

, 2013
Proton relative biological effectiveness (RBE) is known to depend on the (alpha/beta)(x) of irradiated tissues, with evidence of similar to 60% variation over (alpha/beta)(x) values from 1-10 Gy.
Carabe, Alejandro, Espana Palomares, Samuel, Grassberger, Clemens, Paganetti, Harald   +3 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

The Future of Proton Therapy

, 2021
Proton therapy is increasing in utilization worldwide at a rapid rate. With process improvements in costs, footprints, and continued advances in the delivery of care, including intensity modulation and image guidance, proton therapy may evolve into standard treatment with photon radiation therapy.
Allison Sacher, Michael Anderegg, Kevin C. O’Connor, James Shen, Fenghong Liu, Linda Ding, Ameer L. Elaimy, Eric Ko, Jack Bailey, T.J. FitzGerald, Harry Bushe, Daniel Han, I-Lin Kuo, Paul Rava, Jonathan Saleeby, Suhong Yu, Janaki Moni, Carla Bradford, M. Giulia Cicchetti, Christopher Riberdy, Shirin Sioshansi, Maryann Bishop-Jodoin, Yankhua Fan   +22 more
openaire   +4 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source