Results 51 to 60 of about 249,684 (338)

Dosimetric comparison study between intensity modulated radiation therapy and three-dimensional conformal proton therapy for pelvic bone marrow sparing in the treatment of cervical cancer. [PDF]

, 2010
The objective was to compare intensity-modulated radiation therapy (IMRT) with 3D conformal proton therapy (3DCPT) in the treatment of cervical cancer. In particular, each technique's ability to spare pelvic bone marrow (PBM) was of primary interest in ...
Huh, Soon N, Liang, Yun, Mell, Loren K, Mundt, Arno J, Nichols, R Charles, Song, William Y, Watkins, W Tyler, White, Greg   +7 more
core   +2 more sources

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Clinical outcomes of image-guided proton therapy for histologically confirmed stage I non-small cell lung cancer

Radiation Oncology, 2018
Background Two prospective phase II trials were designed to assess the efficacy and safety of image-guided proton therapy (IGPT) for either medically inoperable or operable stage I non-small cell lung cancer (NSCLC). The present study reports the interim
Koichiro Nakajima, Hiromitsu Iwata, Hiroyuki Ogino, Yukiko Hattori, Shingo Hashimoto, Toshiyuki Toshito, Kensuke Hayashi, Kenji Akita, Fumiya Baba, Katsumi Nakamae, Jun-etsu Mizoe, Yuta Shibamoto   +11 more
doaj   +1 more source

Spatial fractionation of the dose in proton therapy: Proton minibeam radiation therapy

Cancer/Radiothérapie, 2019
In radiation therapy, a renewed interest is emerging for the study of spatially fractionated irradiation. In this article, a few applications using spatial fractionation of the dose will be discussed with a focus on proton minibeam radiation therapy. Examples of calculated dose (1D profiles and 2D dose distributions) and biological evidence obtained so
Consuelo Guardiola, Consuelo Guardiola, Annalisa Patriarca, T. Schneider, T. Schneider, H. Mammar, Frederic Pouzoulet, Yolanda Prezado, Yolanda Prezado, Rémi Dendale, L. De Marzi, L. De Marzi, Catherine Nauraye, P. Lansonneur   +13 more
openaire   +6 more sources

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

The grid-dose-spreading algorithm for dose distribution calculation in heavy charged particle radiotherapy [PDF]

, 2007
A new variant of the pencil-beam (PB) algorithm for dose distribution calculation for radiotherapy with protons and heavier ions, the grid-dose spreading (GDS) algorithm, is proposed.
Ahnesjö, Azusa Ishizaki, Bortfeld, Deasy, Endo, Hollmark, Hong, Kanai, Kanematsu, Kanematsu, Kanematsu, Kanematsu, Kanematsu, Kohno, Krämer, Langen, Lomax, Mackie, Mackie, Nobuyuki Kanematsu, Noda, Petti, Russell, Schaffner, Sharpe, Shunsuke Yonai, Soukup, Szymanowski, Tsuji, Yan   +29 more
core   +3 more sources

Proton beam therapy achieves excellent local control for recurrent epithelial ovarian cancer: a single-center retrospective study

Journal of Ovarian Research
Background Previous studies have demonstrated the benefit of radiation therapy for patients with recurrent epithelial ovarian cancer; however, the effects of proton beam therapy in these patients remain unelucidated.
Yuta Endo, Yoshiaki Takagawa, Yuki Yoshimoto, Masanori Machida, Yuntao Dai, Yusuke Azami, Ichiro Seto, Kanako Takayama, Motohisa Suzuki, Tatsuhiko Nakasato, Yasuhiro Kikuchi, Takahiro Kato, Akiko Yamaguchi, Shu Soeda, Keiya Fujimori, Masao Murakami   +15 more
doaj   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

Proton Pump Inhibitors Therapy in Children with Gastroesophageal Reflux [PDF]

, 2013
Proton pump inhibitors (PPI) has been widely used by clinicians to treat diseases that require suppression of gastric acid. PPI work by inhibiting the proton pump in gastric parietal cells.In adult patients, PPI hasbeen widely studied and showed ...
Hegar, B. (Badriul), Reynaldo, A. (Aldo)
core