Results 51 to 60 of about 5,204,838 (351)

Implementation of Monte Carlo based PET verification of ion beam delivery into a TPS

Radiation Medicine and Protection, 2022
Objective: To develop and implement an ion beam teletherapy verification system based upon simulations of induced radioactivity and comparison with patient positron emission tomography (PET) scans.
Pablo Yepes, Zhuangming Shen, Michael F. Moyers, Qianxia Wang, Hongliang Chen, Jie Li, Yongqiang Li, James Lin   +7 more
doaj   +1 more source

Online daily adaptive proton therapy.

British Journal of Radiology, 2020
It is recognised that the use of a single plan calculated on an image acquired some time before the treatment is generally insufficient to accurately represent the daily dose to the target and to the organs at risk. This is particularly true for protons,
F. Albertini, M. Matter, L. Nenoff, Ye Zhang, A. Lomax   +4 more
semanticscholar   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

Outcomes and Prognostic Factors for Locally Recurrent Rectal Cancer Treated With Proton Beam Therapy

Advances in Radiation Oncology, 2023
Purpose: Our objective was to report the outcome and prognostic factors for patients with locally recurrent rectal cancer (LRRC) treated with proton beam therapy (PBT) at our institution.
Yoshiaki Takagawa, MD, Motohisa Suzuki, MD, Hisashi Yamaguchi, MD, Ichiro Seto, MD, Yusuke Azami, MD, PhD, Masanori Machida, MD, Kanako Takayama, DDS, PhD, Takuya Tominaga, DDS, Masao Murakami, MD, PhD   +8 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Dosimetric analysis of local failures in skull-base chordoma and chondrosarcoma following pencil beam scanning proton therapy

Radiation Oncology, 2020
Background Despite combined modality treatment involving surgery and radiotherapy, a relevant proportion of skull-base chordoma and chondrosarcoma patients develop a local recurrence (LR).
Lucas Basler, Robert Poel, Christina Schröder, Alessandra Bolsi, Antony Lomax, Stephanie Tanadini-Lang, Matthias Guckenberger, Damien C. Weber   +7 more
doaj   +1 more source

Verification of an independent dose calculation method for portal-specific QA of proton and carbon ion beams

Radiation Medicine and Protection, 2022
Objective: To verify the accuracy of an independent dose calculation method, as incorporated into an in-house developed treatment planning system (TPS), for performing quality assurance of dose distributions delivered to a water phantom planned by a ...
Michael F. Moyers, Qianxia Wang, Yu Deng, Hongliang Chen, Zhi Chen, Xiaoli Liu, Nicki Schlegel, Jie Li, Zhuangming Shen, James Lin, Pablo Yepes   +10 more
doaj   +1 more source

AAPM task group 224: Comprehensive proton therapy machine quality assurance.

Medical Physics (Lancaster), 2019
PURPOSE  Task Group (TG) 224 was established by the American Association of Physicists in Medicine's Science Council under the Radiation Therapy Committee and Work Group on Particle Beams.
B. Arjomandy, P. Taylor, C. Ainsley, S. Safai, N. Sahoo, M. Pankuch, J. Farr, Sung Yong Park, E. Klein, J. Flanz, E. Yorke, D. Followill, Y. Kase   +12 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source