Results 111 to 120 of about 48,025 (297)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Precision shooting: Sampling long transition pathways
, 2008 The kinetics of collective rearrangements in solution, such as protein folding and nanocrystal phase transitions, often involve free energy barriers that are both long and rough.
Dellago, C. +2 more
core +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Cogent Social SciencesThe phenomenon of protracted refugee situations and the conditions of refugees living in the same situation have renewed debates on durable refugee solutions.
Samuel Opono, Frank Ahimbisibwe
doaj +1 more source
Recovery of normal heat conduction in harmonic chains with correlated disorder
, 2015 We consider heat transport in one-dimensional harmonic chains with isotopic disorder, focussing our attention mainly on how disorder correlations affect heat conduction.
Herrera-González, I. F. +2 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Daring to dream of an end to exile in sub-Saharan Africa [PDF]
Forced Migration Review, 2009 Almost 98% of the refugees in Africa today could beconsidered as in protracted refugee situations. We needconcerted efforts to draw as many as possible to a close.
Marjon Kamara
doaj
The Political Economy of Refugee Migration [PDF]
This article examines the driving forces of the magnitude, composition and duration of refugee movements caused by conflict and persecution. The decision to seek temporary or permanent refuge in the region of origin or in a more distant asylum ...
Mathias Czaika
core
Selective wear of cuttings elements of working organs of tillage machines with realization of self-sharpening effect [PDF]
, 2013 The clause of strengthening of cuttings elements is conditioning and realization of such selforganization process as a self-sharpening. Sharpening of horizontal and vertical cuttings elements of working organs of tillage machines (CE WOTM) is considered ...
Aulin, V. +2 more
core