Results 111 to 120 of about 190,002 (301)

Islet Amyloid Polypeptide Modelled to Simulate Diabetes Co‐Oligomerized with β‐Amyloid 1‐42 Reproducing the Pathological Cascade of Alzheimer's Disease in Human Cerebral Organoids

Advanced Science, EarlyView.
Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan, Zhimeng Tang, Yanyu Luo, Bin Liu, Xinxin Huang, Jun Wei, Feng Yue   +6 more
wiley   +1 more source

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

Orthognathic correction and corticobasal implant-supported prostheses as a treatment modality for partial edentulism with mandibular prognathism: A case report and review of literature. [PDF]

Int J Surg Case Rep, 2022
Ahmad AG, Osman M, Awadalkreem F.
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Experimental Performances of Titanium Redox Electrodes as the Substitutes for the Ruthenium-Iridium Coated Electrodes Used in the Reverse Electrodialysis Cells for Hydrogen Production. [PDF]

Membranes (Basel)
Han Z, Wu X, Xu L, He P.
europepmc   +1 more source

Fabrication of Polymer Microfluidics: An Overview. [PDF]

Polymers (Basel), 2022
Juang YJ, Chiu YJ.
europepmc   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Bacterial Leakage Testing in Dentistry: A Comprehensive Review on Methods, Models, and Clinical Relevance. [PDF]

Scientifica (Cairo)
Snigdha NT, Karobari MI.
europepmc   +1 more source

Examination of the Long-term Subsurface Warming Observed at the Apollo 15 and 17 Sites Utilizing the Newly Restored Heat Flow Experiment Data from 1975 to 1977 [PDF]

The Apollo Heat Flow Experiment (HFE) was conducted at landing sites 15 and 17. On Apollo 15, surface and subsurface temperatures were monitored from July 1971 to January 1977. On Apollo 17, monitoring took place from December 1972 to September 1977. The
Kiefer, W. S., Nagihara, S., Nakamura, Y., Taylor, P. T., Williams, D. R.   +4 more
core   +1 more source

Engineered Interpenetrating MXene Networks in Aramid Layered Films for Antioxidant and Broadband Electromagnetic Interference Shielding

Advanced Science, EarlyView.
This study introduces an innovative interpenetrating layered structure, comprising alternating aramid nanofiber (ANF) layers and MXene layers, fabricated through a directional freeze–thaw intercalation–gel‐film formation strategy. Unlike traditional homogeneous layered films, this unique layered structure features mutually embedded conductive and ...
Hongli Cheng, Gaojie Han, Congqi Liu, Yang Zhou, Yiming Wang, Bing Zhou, Yuezhan Feng, Chuntai Liu, Hao‐Bin Zhang, Changyu Shen   +9 more
wiley   +1 more source