Results 241 to 250 of about 2,293,849 (307)
A modular "Catch-and-Play" platform for rapid T-cell engager target assembly for personalised cancer treatment. [PDF]
Signal Transduct Target TherXi X +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Response to letter regarding 'local large arterial perivascular adipose tissue metabolic and anatomical features are associated with hypertensive clinical outcomes: a PET/CT-Based study'. [PDF]
Ann MedLong HY, Chen GD, Chen BQ.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Potential Distribution Pattern and Ecological Suitability Analysis of <i>Hippophae Tibetana</i> Schltdl in China Based on the MaxEnt Model. [PDF]
Ecol EvolMa T, Yong D, Xu D, He Z, Zhuo Z.
europepmc +1 more source