Results 1 to 10 of about 66,750 (285)
Transcriptional and Epigenetic Regulatory Mechanisms Affecting HTLV-1 Provirus [PDF]
Viruses, 2016 Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus associated with human diseases, such as adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/Tropic spastic paraparesis (HAM/TSP). As a retrovirus, its life cycle includes a step where HTLV-1 is integrated into the host genomic DNA and forms proviral DNA.
Paola Miyazato +3 more
semanticscholar +6 more sources
mBio, 2022 Current antiretroviral treatment fails to cure HIV-1 infection since latent provirus resides in long-lived cellular reservoirs, rebounding whenever therapy is discontinued.
Julie Janssens +3 more
doaj +3 more sources
A CRISPR/Cas9 guidance RNA screen platform for HIV provirus disruption and HIV/AIDS gene therapy in astrocytes [PDF]
Scientific Reports, 2017 HIV/AIDS remains a major health threat despite significant advances in the prevention and treatment of HIV infection. The major reason is the inability of existing treatments to eradicate the multiple HIV reservoirs in the human body, including ...
Zaohua Huang, Madahavan Nair
doaj +3 more sources
Provirus activation plus CD59 blockage triggers antibody-dependent complement-mediated lysis of latently HIV-1-infected cells [PDF]
Journal of Immunology, 2014 Latently HIV-1-infected cells are recognized as the last barrier toward viral eradication and cure. To purge these cells, we combined a provirus stimulant with a blocker of human CD59, a key member of the regulators of complement activation, to trigger ...
Amet, Tohti +10 more
core +5 more sources
The integrated HIV-1 provirus in patient sperm chromosome and its transfer into the early embryo by fertilization. [PDF]
PLoS ONE, 2011 Complete understanding of the route of HIV-1 transmission is an important prerequisite for curbing the HIV/AIDS pandemic. So far, the known routes of HIV-1 transmission include sexual contact, needle sharing, puncture, transfusion and mother-to-child ...
Dian Wang +10 more
doaj +4 more sources
Evolutionary insights into provirus-encoded CRISPR-Cas systems in halophilic archaea. [PDF]
MicrolifeNaki D, Gophna U.
europepmc +4 more sources
t-RNA mediates provirus deletion in HIV-infected cells. [PDF]
RetrovirologyGurgo C, Franchini G.
europepmc +3 more sources
Cells, 2021 Eradication of latent human immunodeficiency virus (HIV) infection is a global health challenge. Reactivation of HIV latency and killing of virus-infected cells, the so-called “kick and kill” or “shock and kill” approaches, are a popular strategy for HIV
Sushant Khanal +4 more
doaj +1 more source
Viruses, 2021 Feline leukemia virus (FeLV) is a retrovirus of cats worldwide. High viral loads are associated with progressive infection and the death of the host, due to FeLV-associated disease. In contrast, low viral loads, an effective immune response, and a better
A. Katrin Helfer-Hungerbuehler +5 more
doaj +1 more source
The First Genomic Analysis of Visna/Maedi Virus Isolates in China
Frontiers in Veterinary Science, 2022 Visna/Maedi virus (VMV) is a neglected pathogen that damages sheep and goats' nervous and respiratory systems. The virus was discovered 80 years ago and has been endemic in China for nearly four decades; nevertheless, there is little information ...
Jian-Yong Wu +6 more
doaj +1 more source