The integrated HIV-1 provirus in patient sperm chromosome and its transfer into the early embryo by fertilization. [PDF]
PLoS ONE, 2011 Complete understanding of the route of HIV-1 transmission is an important prerequisite for curbing the HIV/AIDS pandemic. So far, the known routes of HIV-1 transmission include sexual contact, needle sharing, puncture, transfusion and mother-to-child ...
Dian Wang +10 more
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Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1983 Human retrovirus adult T-cell leukemia virus (ATLV) has been shown to be closely associated with human adult T-cell leukemia (ATL) [Yoshida, M., Miyoshi, I. & Hinuma, Y. (1982) Proc. Natl. Acad. Sci. USA 79, 2031-2035]. The provirus of ATLV integrated in
Motoharu Seiki +3 more
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mBio, 2022 Current antiretroviral treatment fails to cure HIV-1 infection since latent provirus resides in long-lived cellular reservoirs, rebounding whenever therapy is discontinued.
Julie Janssens +3 more
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Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1984 The genome of human T-cell leukemia virus (HTLV) was surveyed in fresh tumor cells of 163 patients with lymphoma and leukemia from the southwest part of Japan where adult T-cell leukemia (ATL) is endemic.
Minoru Yoshida +3 more
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Lower HIV provirus levels are associated with more APOBEC3G protein in blood resting memory CD4+ T lymphocytes of controllers in vivo. [PDF]
PLoS ONE, 2013 Immunodeficiency does not progress for prolonged periods in some HLA B57- and/or B27-positive subjects with human immunodeficiency virus type 1 (HIV) infection, even in the absence of antiretroviral therapy (ART).
Mariapia De Pasquale +3 more
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Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines
Nature Communications, 2018 During HIV infection, antiviral therapy can suppress viraemia to undetectable levels and hinder the progression towards AIDS; however the HIV-1 provirus can remain in long-lived CD4+ memory T cells.
Sean Matthew McCauley +6 more
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Chromatin maturation of the HIV-1 provirus in primary resting CD4+ T cells.
PLoS Pathogens, 2020 Human immunodeficiency virus type 1 (HIV-1) infection is a chronic condition, where viral DNA integrates into the genome. Latently infected cells form a persistent, heterogeneous reservoir that at any time can reactivate the integrated HIV-1.
Birgitta Lindqvist +4 more
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Scientific Reports, 2017 HIV/AIDS remains a major health threat despite significant advances in the prevention and treatment of HIV infection. The major reason is the inability of existing treatments to eradicate the multiple HIV reservoirs in the human body, including ...
Zaohua Huang, Madahavan Nair
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Heparanase, a host gene that potently restricts retrovirus transcription [PDF]
mBioHeparanase (HPSE) is a heterodimeric β-D-glucuronidase that is critical in mammalian cells for the enzymatic cleavage of membrane-associated heparan sulfate moieties.
Brandon Waxman +5 more
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Impact of chromatin on HIV-1 latency: a multi-dimensional perspective [PDF]
Epigenetics & ChromatinHuman immunodeficiency virus type 1 (HIV-1) is a retrovirus that infects multiple immune cell types and integrates into host cell DNA termed provirus.
Joanna E. Jones +3 more
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