Results 91 to 100 of about 40,345 (282)
The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells. [PDF]
, 2015 Lentiviral vectors designed for the treatment of the hemoglobinopathies require the inclusion of regulatory and strong enhancer elements to achieve sufficient expression of the β-globin transgene.
Baldwin, Kismet M +12 more
core +4 more sources
The latent HIV reservoir: current advances in genetic sequencing approaches
mBio, 2023 Multiple cellular HIV reservoirs in diverse anatomical sites can undergo clonal expansion and persist for years despite suppressive antiretroviral therapy, posing a major barrier toward an HIV cure.
Preeti Moar +3 more
doaj +1 more source
Dimerisation of HIV-2 genomic RNA is linked to efficient RNA packaging, normal particle maturation and viral infectivity. [PDF]
, 2007 BACKGROUND: Retroviruses selectively encapsidate two copies of their genomic RNA, the Gag protein binding a specific RNA motif in the 5' UTR of the genome.
Andrew ML Lever (60785) +3 more
core +3 more sources
Dynamical Analysis of an HIV Infection Model Including Quiescent Cells and Immune Response
Mathematical Methods in the Applied Sciences, EarlyView.ABSTRACT This research gives a thorough examination of a human immunodeficiency virus (HIV) infection model that includes quiescent cells and immune response dynamics in the host. The model, represented by a system of ordinary differential equations, captures the complex interaction between the host's immune response and viral infection.
Ibrahim Nali +3 more
wiley +1 more source
Journal of Virology, 2016 Understanding the mechanisms of HIV proviral latency is essential for development of a means to eradicate infection and achieve a cure. We have previously described an in vitro latency model that reliably identifies HIV expression phenotypes of infected ...
F. Hashemi +5 more
semanticscholar +1 more source
Microbiology and Immunology, EarlyView.ABSTRACT Bovine leukemia virus (BLV) causes Enzootic bovine leukosis (EBL) in approximately 1%–5% of infected cattle after a long latent period. Few biomarkers effectively distinguish non‐EBL from EBL cattle. Given the rapid turnover of tumor cells, we hypothesized that cell‐free DNA (cfDNA) in plasma could serve as a more effective biomarker for EBL ...
M. Ishrat Jahan +11 more
wiley +1 more source
Highly Efficient Gene Expression in B Lymphocytes Mediating by Lentivirus Vector [PDF]
, 2012 Gene transduction and expression efficiencies among several type cell lines were compared by using vesicular stomatitis virus-glycoprotein (VSV-G) pseudotyped human immunodeficiency virus type-1 (HIV-1) based lentivirus vector. Large discrepancies of the
Akira Tempaku
core +1 more source
Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption. [PDF]
, 2018 Combination antiretroviral therapy controls but does not cure HIV-1 infection because a small fraction of cells harbor latent viruses that can produce rebound viremia when therapy is interrupted. The circulating latent virus reservoir has been documented
Barton, John +13 more
core +1 more source
Prevalence of Different Courses of Feline Leukaemia Virus Infection in Four European Countries
Viruses, 2023 Prevalence of progressive feline leukaemia virus (FeLV) infection is known to still be high in cats in Europe, especially in Southern Europe, but the prevalence of other outcomes of FeLV infection has not been determined in most countries.
Juliana Giselbrecht +13 more
doaj +1 more source
Australian Veterinary Journal, EarlyView.Progressive feline leukaemia virus (FeLV) infection dramatically shortens the lives of infected cats, causing acquired immunodeficiency, aplastic anaemia, lymphoma, leukaemia and other myeloproliferative diseases. The potential impact of regressive FeLV infection on the development of disease remains largely unknown, although there is evidence it ...
ME Westman +6 more
wiley +1 more source