Results 91 to 100 of about 66,750 (285)

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

Scientific Reports, 2013
Even though highly active anti-retroviral therapy is able to keep HIV-1 replication under control, the virus can lie in a dormant state within the host genome, known as a latent reservoir and poses a threat to re-emerge at any time.
Hirotaka Ebina, N. Misawa, Yuka Kanemura, Y. Koyanagi   +3 more
semanticscholar   +1 more source

Impact of BoLA‐DRB3 Polymorphisms on Clonality of Bovine Leukaemia Virus‐Infected Cells of Cattle With Lymphoma

HLA, Volume 107, Issue 2, February 2026.
ABSTRACT Bovine leukaemia virus (BLV) infects cattle, integrates into the host genome as a provirus, and induces a persistent infection that remains asymptomatic but can cause leukaemia/lymphoma. Most BLV‐infected cell clones are created by massive depletion, and a few of these infected cell clones expand through the mitotic cycle, leading to the onset
Noriko Fukushi, Meripet Polat Yamanaka, Ryosuke Matsuura, Sonoko Watanuki, Susumu Saito, Yasunobu Matsumoto, Keisuke Fukumoto, Kazuyoshi Hosomichi, Jinliang Wang, Shin‐nosuke Takeshima, Yoko Aida   +10 more
wiley   +1 more source

Defective HIV proviruses: possible involvement in the HIV infection pathogenesis

Вопросы вирусологии
This review article analyzes information obtained from a literature search on defective HIV genomes (HIV-1, Human Immunodeficiency Virus, Lentivirus, Orthoretrovirinae, Retroviridae). It discusses the origins of defective HIV genomes, their potential for
Marina R. Bobkova
doaj   +1 more source

The latent HIV reservoir: current advances in genetic sequencing approaches

mBio, 2023
Multiple cellular HIV reservoirs in diverse anatomical sites can undergo clonal expansion and persist for years despite suppressive antiretroviral therapy, posing a major barrier toward an HIV cure.
Preeti Moar, Thomas A. Premeaux, Andrew Atkins, Lishomwa C. Ndhlovu   +3 more
doaj   +1 more source

Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. [PDF]

, 2019
BackgroundHIV-infected cell lines are widely used to study latent HIV infection, which is considered the main barrier to HIV cure. We hypothesized that these cell lines differ from each other and from cells from HIV-infected individuals in the mechanisms
Aran, Dvir, Butte, Atul J, Greene, Warner C, Hsieh, Christine, Joshi, Sunil, Kim, Peggy, Montano, Mauricio, Morón-López, Sara, Telwatte, Sushama, Wong, Joseph K, Yukl, Steven A   +10 more
core   +1 more source

Diagnostic utility and pitfalls of human T‐lymphotropic virus serology in adult T‐cell leukemia/lymphoma: evidence from a 25‐year pathology‐based nonendemic cohort

The Journal of Pathology: Clinical Research, Volume 12, Issue 1, January 2026.
Abstract Adult T‐cell leukemia/lymphoma (ATLL) is a distinct type of peripheral T‐cell lymphoma (PTCL) driven by human T‐lymphotropic virus type I (HTLV‐1)–infected T cells, but diagnosis can be confounded by histological overlap with non‐ATLL PTCL. While molecular testing is the diagnostic gold standard in endemic areas, HTLV‐1/2 serology is often ...
Chang‐Tsu Yuan, Li‐Yu Sun, Shih‐Sung Chuang, Kennosuke Karube, Hsiao‐Bai Yang, Sze‐Hwei Lee, Ren‐Ching Wang, Kung‐Chao Chang, Chein‐Jun Kao, Huai‐Hsuan Huang, Wen‐Chien Chou   +10 more
wiley   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Distinct viral reservoirs and immune signatures in individuals on long-term antiretroviral therapy with perinatally acquired HIV-1

Cell Reports Medicine
Summary: Early initiation of antiretroviral therapy (ART) following HIV-1 infection restricts the size of the latent reservoir, following both horizontal and vertical infections.
Benjamin Bone, Nicola Cotugno, Chiara Pighi, Arianna Rotili, Seohyun Hong, Leah Carrere, Elena Morrocchi, Giuseppe Rubens Pascucci, Ce Gao, Nicole Colantoni, Weiwei Sun, Giovanna Leone, David R. Collins, Mpho J. Olatotse, Giovanna Del Principe, Toong Seng Tan, Melanie Lancien, Alessia Neri, Libera Sessa, Giulio Olivieri, Kailey Shapiro, Isabelle Roseto, Catherine Koofhethile, Elena Emili, Stefania Bernardi, Ann Chahroudi, Paolo Rossi, Bruce D. Walker, Xu G. Yu, Mathias Lichterfeld, Paolo Palma   +30 more
doaj   +1 more source

Retroviral DNA—the silent winner: blood transfusion containing latent feline leukemia provirus causes infection and disease in naïve recipient cats

Retrovirology, 2015
The feline leukemia virus (FeLV) is a gamma-retrovirus of domestic cats that was discovered half a century ago. Cats that are infected with FeLV may develop a progressive infection resulting in persistent viremia, immunodeficiency, tumors, anemia and ...
Stefanie Nesina, A. Katrin Helfer-Hungerbuehler, B. Riond, F. Boretti, B. Willi, M. Meli, P. Grest, R. Hofmann-Lehmann   +7 more
semanticscholar   +1 more source

Diversity and Ecological Potentials of Marine Viruses Inhabiting Continental Shelf Seas

Advanced Science, Volume 13, Issue 1, 5 January 2026.
To the best of the knowledge, this study provides the largest viral genome dataset from a continental shelf sea. It reveals that over half of vOTUs are novel, highlighting the remarkable viral novelty in the eastern continental shelf seas of China (ECSSC).
Xiaoyue Guo, Yantao Liang, Chen Gao, Hao Yu, Meiwen Wang, Hongbing Shao, Yeqing Yang, David Paez‐Espino, Andrew McMinn, Min Wang   +9 more
wiley   +1 more source