Results 101 to 110 of about 66,750 (285)

Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses [PDF]

, 2017
G-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter.
A Ayouba, A Henderson, A Rambaut, AK Todd, AM Fleming, AN Lane, AR Haeusler, B Berkhout, B Zhou, BF Keele, D Piekna-Przybylska, D Qu, D Rhodes, D Sen, DJ Patel, E Tosoni, EA Raiber, F Barre-Sinoussi, F Benachenhou, F Bibollet-Ruche, F Heuverswyn Van, F Turrini, G Biffi, GE Crooks, IT Holder, J Felsenstein, J Norseen, J Qiu, J Song, J Yamaguchi, JE Clements, JF Fisette, JP Taylor, K Tamura, K Tluckova, KA Jones, LA Pereira, M Fry, M Metifiot, M Sala, M Scalabrin, MA Larkin, N Maizels, ND Perkins, NH Campbell, P Fratta, P Ivanov, P Murat, P Sket, R Perrone, R Perrone, R Perrone, R Perrone, RC Edgar, RC Gallo, RJ Gifford, S Amrane, S Artusi, S Artusi, S Balasubramanian, S Bhatia, S Broos, S Burge, S Pohlmann, SE Tong-Starksen, SR Wang, SR Wang, Y Wang   +67 more
core   +1 more source

Activation of an oncogenic microRNA cistron by provirus integration [PDF]

Proceedings of the National Academy of Sciences, 2006
Retroviruses can cause tumors when they integrate near a protooncogene or tumor suppressor gene of the host. We infected >2,500 mice with the SL3-3 murine leukemia virus; in 22 resulting tumors, we found provirus integrations nearby or within the gene that contains the mir-17-92 microRNA (miRNA) cistron.
Clifford L, Wang, Bruce B, Wang, Gábor, Bartha, Lauri, Li, Namitha, Channa, Mark, Klinger, Nigel, Killeen, Matthias, Wabl   +7 more
openaire   +2 more sources

Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1

Retrovirology, 2015
BackgroundHIV-1 escapes antiretroviral drugs by integrating into the host DNA and forming a latent transcriptionally silent HIV-1 provirus. This provirus presents the major hurdle in HIV-1 eradication and cure.
M. Tyagi, S. Iordanskiy, T. Ammosova, N. Kumari, Kahli A. Smith, Denitra Breuer, A. Ilatovskiy, Yasemin Saygideğer Kont, Andrey Ivanov, Aykut Üren, D. Kovalskyy, M. Petukhov, F. Kashanchi, S. Nekhai   +13 more
semanticscholar   +1 more source

CXCR3/CXCL10 Axis‐Mediated T Cell Infiltration in the Lungs of Patients With HTLV‐1‐Associated Diseases: Implications for Subclinical Pulmonary Involvement

Journal of Medical Virology, Volume 98, Issue 1, January 2026.
Abstract HTLV‐1 is a retrovirus associated with adult T cell leukemia/lymphoma (ATL) and inflammatory diseases, including HTLV‐1‐associated myelopathy (HAM) and HTLV‐1‐associated bronchopneumonopathy (HAB). Although pulmonary complications are common in HTLV‐1‐associated diseases, the underlying mechanisms remain unclear.
Kanako Tsuchimoto, Ayasa Mori, Masakazu Tanaka, Shiho Arishima, Daisuke Kodama, Mika Dozono, Satoshi Nozuma, Hiroshi Takashima, Ryuji Kubota   +8 more
wiley   +1 more source

BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1

Scientific Reports, 2018
HIV-1 latent reservoirs harbouring silenced but replication-competent proviruses are a major obstacle against viral eradication in infected patients. The “shock and kill” strategy aims to reactivate latent provirus with latency reversing agents (LRAs) in
Jin Gohda, Kazuo Suzuki, Kai Liu, Xialin Xie, Hiroaki Takeuchi, Jun-ichiro Inoue, Yasushi Kawaguchi, Takaomi Ishida   +7 more
doaj   +1 more source

Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals [PDF]

, 2020
Background: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regulation in cultured cells.
De Meyer, Tim, De Spiegelaere, Ward, Kinloch-de Loes, Sabine, Kint, Sam, Malatinková, Eva, Trypsteen, Wim, Van Criekinge, Wim, Vandekerckhove, Linos   +7 more
core   +2 more sources

Genomic Validation of PERV‐C‐Free Pigs to Support Xenotransplantation

Xenotransplantation, Volume 33, Issue 1, January/February 2026.
ABSTRACT Porcine endogenous retroviruses (PERVs) are present in the germ lines of domesticated pigs (Sus scrofa) and related suids. There are three types of PERVs, PERV‐A, ‐B, and ‐C, which differ in their host range. PERV‐A and ‐B can infect human and porcine cells, while PERV‐C only infects porcine cells. PERV‐A and ‐B are found in the genomes of all
Neal R. Benjamin, Giovanni Madrigal, Yasuko Ishida, Julian Catchen, Kari L. Allen, Brent Pepin, Alfred L. Roca   +6 more
wiley   +1 more source

Differential Expression of Human Endogenous Retroviruses‐W in Multiple Sclerosis and Epilepsy: A Comparative Study With Healthy Controls

Advances in Virology, Volume 2026, Issue 1, 2026.
Human endogenous retroviruses (HERVs) are the remnants of viral infections that occurred in our ancestors, subsequently integrated into the human genome. They make up about 8% of the human genome. Increased HERV expression occurs in physiological and pathological conditions, especially neurological diseases.
Sina Mahdavi, Vahdat Poortahmasebi, Daryoush Savadi Oskouei, Arezou Azadi, Sara Mafi, Javid Sadeghi, Hossein Bannazadeh Baghi, Mahin Ahangar Oskouee, Jasbir Arora (RSS)   +8 more
wiley   +1 more source

Provirus Mutations of Human T-Lymphotropic Virus 1 and 2 (HTLV-1 and HTLV-2) in HIV-1-Coinfected Individuals

mSphere, 2020
Provirus mutations of human T-lymphotropic virus 1 (HTLV-1), mostly the lack of the 5′ long terminal repeat (LTR) genomic region, have been described and associated with severe adult T cell leukemia/lymphoma (ATLL), non-sense point mutations with low ...
Karoline Rodrigues Campos, Adele Caterino-de-Araujo   +1 more
doaj   +1 more source

Development and validation of a new high-throughput method to investigate the clonality of HTLV-1-infected cells based on provirus integration sites

Genome Medicine, 2014
Transformation and clonal proliferation of T-cells infected with human T-cell leukemia virus type-I (HTLV-1) cause adult T-cell leukemia. We took advantage of next-generation sequencing technology to develop and internally validate a new methodology for ...
Sanaz Firouzi, Yosvany López, Yutaka Suzuki, K. Nakai, S. Sugano, T. Yamochi, Toshiki Watanabe   +6 more
semanticscholar   +1 more source