Results 111 to 120 of about 40,345 (282)

BI-2536 and BI-6727, dual Polo-like kinase/bromodomain inhibitors, effectively reactivate latent HIV-1

open access: yesScientific Reports, 2018
HIV-1 latent reservoirs harbouring silenced but replication-competent proviruses are a major obstacle against viral eradication in infected patients. The “shock and kill” strategy aims to reactivate latent provirus with latency reversing agents (LRAs) in
Jin Gohda   +7 more
doaj   +1 more source

Prevalence of feline leukaemia provirus DNA in feline lymphomas

open access: greenJournal of Feline Medicine and Surgery, 2010
A significant drop in the prevalence of feline leukaemia virus (FeLV) antigenaemic cats and antigen-associated lymphomas has been observed after the introduction of FeLV vaccination and antigen-testing with removal of persistently antigenaemic cats. However, recent reports have indicated that regressively infected cats may contain FeLV provirus DNA ...
Alexander Th. A. Weiss   +2 more
openalex   +4 more sources

Development and validation of a new high-throughput method to investigate the clonality of HTLV-1-infected cells based on provirus integration sites

open access: yesGenome Medicine, 2014
Transformation and clonal proliferation of T-cells infected with human T-cell leukemia virus type-I (HTLV-1) cause adult T-cell leukemia. We took advantage of next-generation sequencing technology to develop and internally validate a new methodology for ...
Sanaz Firouzi   +6 more
semanticscholar   +1 more source

Transcriptional competence of the integrated HIV‐1 provirus at the nuclear periphery [PDF]

open access: yesThe EMBO Journal, 2009
Spatial distribution of genes within the nucleus contributes to transcriptional control, allowing optimal gene expression as well as constitutive or regulated gene repression. Human immunodeficiency virus type 1 (HIV-1) integrates into host chromatin to transcribe and replicate its genome. Lymphocytes harbouring a quiescent but inducible provirus are a
M. Dieudonné   +6 more
semanticscholar   +5 more sources

Adaptive evolution of koala retrovirus transcription silencing and what it means for conservation

open access: yesClinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Abstract Koala populations in Australia face a barrage of threats, chiefly, habitat degradation and the effects of climate change including drought and bushfire. Further, high rates of chlamydiosis, linked to koala retrovirus (KoRV) viral load, is a major contributing factor to northern population decline. However, recent work by Yu et al., (Cell, 2024)
Keith J. Chappell   +3 more
wiley   +1 more source

Is the innate bio-protection power against human virus the same between males and females? A conclusion based on blood donor data of HTLV-I infection [PDF]

open access: yes, 2008
Human T-cell leukemia virus type I (HTLV-I) is a retrovirus that causes adult T-cell leukemia. The male-to-female transmission is stronger than the reverse, so the carrier proportion of women is greater than that of men.
Minoru Tabata   +3 more
core   +1 more source

A Multiplex Real‐Time PCR for Qualitative Detection of Mutton, Pork, Chicken, and Duck in Processed Meat Products

open access: yesFood Science &Nutrition, Volume 13, Issue 7, July 2025.
This study aimed to develop a multiplex real‐time PCR method for the qualitative detection of pork, chicken, and duck adulteration in mutton products. The method exhibited high specificity, accuracy, and sensitivity through method validation. To evaluate its applicability, we analyzed 35 commercial processed meat products, and the results confirmed the
Lijuan Chang   +3 more
wiley   +1 more source

A defective ecotropic provirus closely linked to the albino locus [PDF]

open access: yesJournal of Virology, 1985
A congenic mouse strain (NFS.C) carrying the albino region of chromosome 7 from strain C58/Lw on an ecotropic virus-negative NFS background inherited a noninducible but apparently full-size provirus reactive with an ecotropic virus-specific probe. This unexpressed ecotropic provirus maps close to the albino locus but is distinct from the Fgv-1 provirus
openaire   +3 more sources

Dendritic Cell-induced Activation of Latent HIV-1 Provirus in Actively Proliferating Primary T Lymphocytes

open access: yesPLoS Pathogens, 2013
HIV-1 latency remains a formidable barrier towards virus eradication as therapeutic attempts to purge these reservoirs are so far unsuccessful. The pool of transcriptionally silent proviruses is established early in infection and persists for a lifetime,
Renée M. Van der Sluis   +6 more
semanticscholar   +1 more source

Dual Targeting of Pim and PI3 Kinases in Mature T‐Cell Lymphoma

open access: yesEuropean Journal of Haematology, Volume 115, Issue 1, Page 82-95, July 2025.
ABSTRACT Provirus Integration site for Moloney leukemia virus (Pim) family members are well‐known oncogenes, with an expression that is restricted to few cell types including hematopoietic cells in adult organisms, making it a promising target for lymphoma treatment.
M. Lohrberg   +13 more
wiley   +1 more source

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