Results 111 to 120 of about 66,750 (285)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, Volume 19, Issue 12, Page 3750-3768, December 2025.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses. [PDF]

, 2019
A stable latent reservoir for HIV-1 in resting CD4+ T cells is the principal barrier to a cure1-3. Curative strategies that target the reservoir are being tested4,5 and require accurate, scalable reservoir assays.
Antar, Annukka AR, Beg, Subul A, Bender, Alexandra M, Bertagnolli, Lynn N, Blankson, Joel N, Bruner, Katherine M, Bushman, Frederic D, Capoferri, Adam A, Deeks, Steven G, Fray, Emily J, Gregg, John, Ho, Ya-Chi, Jenike, Katharine M, Kufera, Joshua T, Kwon, Kyungyoon J, Laird, Gregory M, Margolick, Joseph B, Nobles, Christopher, Sengupta, Srona, Siliciano, Janet D, Siliciano, Robert F, Simonetti, Francesco R, Timmons, Andrew, Wada, Nikolas, Wang, Zheng, Zhang, Hao   +25 more
core   +1 more source

Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I. [PDF]

, 2006
In the past several years, a number of cellular proteins have been identified as candidate entry receptors for hepatitis C virus (HCV) by using surrogate models of HCV infection.
Barth, Heidi, Baumert, Thomas, Chisari, Francis V, Kapadia, Sharookh B, McKeating, Jane A   +4 more
core   +2 more sources

Immune‐Related Protein and Non‐Coding RNA Cargo of Extracellular Vesicles Participate in the Chronic Inflammation Induced by HIV Infection

Journal of Extracellular Biology, Volume 4, Issue 12, December 2025.
ABSTRACT Extracellular vesicles (EVs) promote intercellular communication, playing a key role in the secondary immune‐related pathologies driven by chronic inflammation in people living with HIV (PLWH). To identify molecular components within large EVs (lEVs) from PLWH's plasma that may influence immune function and contribute to the pathological ...
Humberto Doriguêtto Gravina, Ricardo Cardoso Castro, Ana Margarida Gonçalves, Julia Oliveira Lima, Fabrícia Heloísa Cavicchioli Sugiyama, Brenda Cavalin Moreira, Mateus da Silva Matias Antunes, Caroline Fontanari, Valdes Roberto Bollela, Yann Yves Lamarre, Fausto Almeida, Simone Kashima, Margarida Saraiva, Nuno Osório, Fabiani Gai Frantz   +14 more
wiley   +1 more source

Exploration of Human Skin Phageome to Reveal Endolysins and Novel Antimicrobial Peptides for Therapeutic Applications

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study uncovers diverse endolysins and novel antimicrobial peptides from the human skin phageome, highlighting their potential to target antibiotic‐resistant pathogens and disrupt virulence mechanisms, paving the way for next‐generation skin therapeutics.
Jibon Kumar Paul, Arzuba Akter, Nurnabi Azad Jewel, Mohimenul Haque Rolin, Daniyal Karim, Raphael Kabir Niloy, Shakhinur Islam Mondal   +6 more
wiley   +1 more source

Importance of continuous monitoring of bovine leukaemia virus infection on farms in bovine leukaemia virus‐endemic areas of Japan

Veterinary Record Open, Volume 12, Issue 2, December 2025.
Abstract Background Enzootic bovine leukosis (EBL), caused by the bovine leukaemia virus (BLV), has exhibited increasing infection rates in Japan. While many farms implement various infection prevention measures, practical challenges—such as barn structure and availability of replacement cattle—can hinder farm purification efforts.
Chikako Tani, Jiazhou Li, Hirohisa Mekata, Kazuhiro Morishita, Shingo Nakahata   +4 more
wiley   +1 more source

Provirus-Anchored Long-Range (PAL) Mapping of Mammalian Genomes

Genomics, 1993
To design a strategy for more efficient long-range physical mapping of large mammalian genomes, we have developed a method for directional mapping from anchor points of randomly integrated retroviral proviruses containing sequences that provide unique cleavage sites in the genome.
B, Kurdi-Haidar, F, Levine, K, Roemer, P, LaPorte, T, Friedmann   +4 more
openaire   +2 more sources

Age‐Associated Expansion of HIV/SIV Reservoirs in People With HIV and SIV‐Infected Macaques

Aging Cell, Volume 24, Issue 12, December 2025.
Virally suppressed older people with HIV have larger peripheral blood CD4+ T‐cell reservoirs than younger individuals, correlating with CD4+ and CD8+ T‐cell activation. Similar results were seen in SIV‐infected, ART‐treated aged rhesus macaques. ABSTRACT With the advancement of combination antiretroviral therapy (ART), over 50% of people with HIV (PWH)
Arpan Acharya, Debapriya Sutar, Mahesh Mohan, Varan Govind, Francois Villinger, Suresh Pallikkuth, Siddappa N. Byrareddy   +6 more
wiley   +1 more source

Dendritic Cell-induced Activation of Latent HIV-1 Provirus in Actively Proliferating Primary T Lymphocytes

PLoS Pathogens, 2013
HIV-1 latency remains a formidable barrier towards virus eradication as therapeutic attempts to purge these reservoirs are so far unsuccessful. The pool of transcriptionally silent proviruses is established early in infection and persists for a lifetime,
Renée M. Van der Sluis, T. van Montfort, G. Pollakis, R. Sanders, D. Speijer, B. Berkhout, R. Jeeninga   +6 more
semanticscholar   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, Volume 599, Issue 21, Page 3012-3028, November 2025.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source