Results 121 to 130 of about 40,345 (282)

The host genomic environment of the provirus determines the abundance of HTLV-1–infected T-cell clones

Blood, 2011
Human T-lymphotropic virus type 1 (HTLV-1) persists by driving clonal proliferation of infected T lymphocytes. A high proviral load predisposes to HTLV-1–associated diseases.
N. Gillet, N. Malani, A. Melamed, N. Gormley, Richard J. Carter, D. Bentley, C. Berry, F. Bushman, G. Taylor, C. Bangham   +9 more
semanticscholar   +1 more source

HTLV‐1 infection altered expression of CCR2, CXCR2, eNOS genes, and oxidative stress in aorta and heart of male mice

Physiological Reports, Volume 13, Issue 11, June 2025.
Abstract Viral infections are associated with the disruption of oxidative stress and the progression of inflammatory mechanisms that play pivotal roles in cardiovascular diseases. In the present study, several inflammatory and oxidative stress markers were examined in HTLV‐1‐infected male BALB/c mice.
Saeed Niazmand, S. A. Rahim Rezaee, Jamshid Gholizadeh Navashenaq, Nema Mohamadian Roshan, Mohsen Ghoryani, Houshang Rafatpanah, Maryam Mahmoudabady, Yousef Baghcheghi, Maryam Paseban, Mahdiyeh Hedayati‐Moghadam   +9 more
wiley   +1 more source

Passive Immunization in the Prevention and Treatment of Viral Infections

European Journal of Immunology, Volume 55, Issue 5, May 2025.
The development of new technologies for generating monoclonal antibodies has made it possible to extend the use of monoclonal antibodies for controlling viral infections. Here, we discuss the advances in antibody cloning techniques and the current use of passive immunization both as a preventative measure and treatment of viral infection.
Romila Moirangthem, Yotam Bar‐On
wiley   +1 more source

Conserved presence of G-quadruplex forming sequences in the Long Terminal Repeat Promoter of Lentiviruses [PDF]

, 2017
G-quadruplexes (G4s) are secondary structures of nucleic acids that epigenetically regulate cellular processes. In the human immunodeficiency lentivirus 1 (HIV-1), dynamic G4s are located in the unique viral LTR promoter.
A Ayouba, A Henderson, A Rambaut, AK Todd, AM Fleming, AN Lane, AR Haeusler, B Berkhout, B Zhou, BF Keele, D Piekna-Przybylska, D Qu, D Rhodes, D Sen, DJ Patel, E Tosoni, EA Raiber, F Barre-Sinoussi, F Benachenhou, F Bibollet-Ruche, F Heuverswyn Van, F Turrini, G Biffi, GE Crooks, IT Holder, J Felsenstein, J Norseen, J Qiu, J Song, J Yamaguchi, JE Clements, JF Fisette, JP Taylor, K Tamura, K Tluckova, KA Jones, LA Pereira, M Fry, M Metifiot, M Sala, M Scalabrin, MA Larkin, N Maizels, ND Perkins, NH Campbell, P Fratta, P Ivanov, P Murat, P Sket, R Perrone, R Perrone, R Perrone, R Perrone, RC Edgar, RC Gallo, RJ Gifford, S Amrane, S Artusi, S Artusi, S Balasubramanian, S Bhatia, S Broos, S Burge, S Pohlmann, SE Tong-Starksen, SR Wang, SR Wang, Y Wang   +67 more
core   +1 more source

Proviral location affects cognate peptide–induced virus production and immune recognition of HIV-1–infected T cell clones

The Journal of Clinical Investigation, 2023
BACKGROUND HIV-1–infected CD4+ T cells contribute to latent reservoir persistence by proliferating while avoiding immune recognition. Integration features of intact proviruses in elite controllers (ECs) and people on long-term therapy suggest that ...
Filippo Dragoni, Abena K. Kwaa, Caroline C. Traut, Rebecca T. Veenhuis, Bezawit A. Woldemeskel, Angelica Camilo-Contreras, Hayley E. Raymond, Arbor G. Dykema, Eileen P. Scully, Amanda M. Rosecrans, Kellie N. Smith, Frederic D. Bushman, Francesco R. Simonetti, Joel N. Blankson   +13 more
doaj   +1 more source

Genetic Evolution Between HIV‐1 Groups M and O: HIV‐1/MO Recombinant Forms

Journal of Medical Virology, Volume 97, Issue 5, May 2025.
ABSTRACT HIV exhibits significant genetic diversity, with genetic recombination being a major evolutionary process. The co‐circulation of HIV‐1/M and HIV‐1/O variants has led to the description of 20 HIV‐1/M+O dual infections since 1998. Despite the genetic divergence between these variants, HIV‐1/M+O dual infections have resulted in the emergence of ...
Alice Moisan, Fabienne Tombette, Jean‐Christophe Plantier   +2 more
wiley   +1 more source

Intramolecular integration within Moloney murine leukemia virus DNA [PDF]

, 1981
By screening a library of unintegrated, circular Moloney murine leukemia virus (M-MuLV) DNA cloned in lambda phage, we found that approximately 20% of the M-MuLV DNA inserts contained internal sequence deletions or inversions.
Baltimore, David, Goff, Stephen P., Hoffmann, Joseph, Shoemaker, Charles   +3 more
core  

A preclinical model for the ATLL lymphoma subtype with insights into the role of microenvironment in HTLV-1-mediated lymphomagenesis [PDF]

, 2018
\uef7f View references (83) Adult T cell Leukemia/Lymphoma (ATLL) is a mature T cell malignancy associated with Human T cell Leukemia Virus type 1 (HTLV-1) infection.
Adriana Mattiolo, Alberto Amadori, Alberto Amadori, Barbara Montini, Ilaria Cavallari, Luigi Chieco-Bianchi, Maria Assunta Piano, Maria Luisa Calabrò, Mattia Vicario   +8 more
core   +2 more sources

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection

Viruses, 2018
Despite significant improvements in therapy, the HIV/AIDS pandemic remains an important threat to public health. Current treatments fail to eradicate HIV as proviral DNA persists in long-living cellular reservoirs, leading to viral rebound whenever ...
Zeger Debyser, Gerlinde Vansant, Anne Bruggemans, Julie Janssens, Frauke Christ   +4 more
doaj   +1 more source

Proviruses with Long-Term Stable Expression Accumulate in Transcriptionally Active Chromatin Close to the Gene Regulatory Elements: Comparison of ASLV-, HIV- and MLV-Derived Vectors

Viruses, 2018
Individual groups of retroviruses and retroviral vectors differ in their integration site preference and interaction with the host genome. Hence, immediately after infection genome-wide distribution of integrated proviruses is non-random.
Dalibor Miklík, Filip Šenigl, Jiří Hejnar   +2 more
doaj   +1 more source