Results 131 to 140 of about 66,750 (285)

Transcriptional provirus silencing as a crosstalk of de novo DNA methylation and epigenomic features at the integration site

Nucleic Acids Research, 2012
The autonomous transcription of integrated retroviruses strongly depends on genetic and epigenetic effects of the chromatin at the site of integration. These effects are mostly suppressive and proviral activity can be finally silenced by mechanisms, such
F. Šenigl, Miroslav Auxt, J. Hejnar
semanticscholar   +1 more source

Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection.

PLoS Pathogens, 2013
The regulation of proviral latency is a central problem in retrovirology. We postulate that the genomic integration site of human T lymphotropic virus type 1 (HTLV-1) determines the pattern of expression of the provirus, which in turn determines the ...
Anat Melamed, Daniel J Laydon, Nicolas A Gillet, Yuetsu Tanaka, Graham P Taylor, Charles R M Bangham   +5 more
doaj   +1 more source

Sequence Instability in the Proviral Long Terminal Repeat and gag Regions from Peripheral Blood and Tissue-Derived Leukocytes of FIV-Infected Cats during the Late Asymptomatic Phase. [PDF]

, 2016
Feline immunodeficiency virus (FIV) infection results in viral persistence, a prolonged asymptomatic phase, and progressive immunopathology. During the asymptomatic phase, a cohort of experimentally FIV-infected cats exhibits features of viral latency in
Eckstrand, Christina D, Hillman, Chadwick, Murphy, Brian G   +2 more
core   +3 more sources

El TARGA como factor determinante en el tamaño del reservorio y la diversidad de los genes accesorios y reguladores del provirus del VIH-1

, 2022
Luis León Fuentes Romero
openalex   +2 more sources

Distribution, diversity and evolution of endogenous retroviruses in perissodactyl genomes [PDF]

, 2018
The evolution of mammalian genomes has been shaped by interactions with endogenous retroviruses (ERVs). In this study, we investigated the distribution and diversity of ERVs in the mammalian order Perissodactyla, with a view to understanding their impact
Gifford, Robert, Murcia, Pablo Ramiro, Zhu, Henan   +2 more
core   +1 more source

Isolation of the mouse mammary tumor virus sequences not transmitted as germinal provirus in the C3H and RIII mouse strains [PDF]

, 1977
William N. Drohan, R. Kettmann, David Colcher, Jeffrey Schlom   +3 more
openalex   +1 more source

Suboptimal Provirus Expression Explains Apparent Nonrandom Cell Coinfection with HIV-1 [PDF]

, 2012
Christelle Brégnard, Grégory Pacini, Olivier Danos, Stéphane Basmaciogullari   +3 more
openalex   +1 more source

People Living With HIV Have More Intact HIV DNA in Circulating CD4+ T Cells if They Have History of Pulmonary Tuberculosis

Pathogens and Immunity
Background: A primary barrier to curing HIV is the HIV reservoir. The leading infectious cause of death worldwide for people living with HIV is tuberculosis (TB), but we do not know how TB impacts the HIV reservoir.
Marc Antoine Jean Juste, Yvetot Joseph, Dominique Lespinasse, Alexandra Apollon, Parmida Jamshidi, Myung Hee Lee, Maureen Ward, Esther Brill, Yanique Duffus, Uche Chukwukere, Ali Danesh, Winiffer Alberto, Daniel Fitzgerald, Jean Pape, R Jones, Kathryn Dupnik   +15 more
doaj   +1 more source

Challenges in Quantifying Cytosine Methylation in the HIV Provirus

mBio, 2019
DNA methylation is an epigenetic mechanism most commonly associated with transcriptional repression. While it is clear that DNA methylation can silence HIV proviral expression in in vitro latency models, its correlation with HIV persistence and expression in vivo is ambiguous, particularly in
Sarah A. LaMere, Antoine Chaillon, Christina Huynh, Davey M. Smith, Sara Gianella   +4 more
openaire   +5 more sources

Impact of chromatin on HIV-1 latency: a multi-dimensional perspective

Epigenetics & Chromatin
Human immunodeficiency virus type 1 (HIV-1) is a retrovirus that infects multiple immune cell types and integrates into host cell DNA termed provirus.
Joanna E. Jones, Chelsea E. Gunderson, Brian Wigdahl, Michael R. Nonnemacher   +3 more
doaj   +1 more source