Results 151 to 160 of about 40,345 (282)

Use of integrase-minus lentiviral vector for transient expression [PDF]

open access: yes, 2012
Objective: Lentivirus-derived vectors are among the most promising viral vectors for gene therapy which is currently available, but their use in clinical practice is limited due to associated risk of insertional mutagenesis.
Azadeh, H.   +5 more
core   +2 more sources

Transcription of HIV-1 at sites of intact latent provirus integration

open access: yesJournal of Experimental Medicine
AbstractHIV-1 anti-retroviral therapy is highly effective but fails to eliminate a reservoir of latent proviruses leading to a requirement for life-long treatment. How the site of integration of authentic intact latent proviruses might impact their own or neighboring gene expression or reservoir dynamics is poorly understood. Here we report on proviral
Ana Rafaela Teixeira   +12 more
openaire   +3 more sources

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles [PDF]

open access: yes, 1996
Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of
Aster, Jon C.   +6 more
core  

Gesicle-Mediated Delivery of CRISPR/Cas9 Ribonucleoprotein Complex for Inactivating the HIV Provirus.

open access: yesMolecular Therapy, 2019
Lee A. Campbell   +5 more
semanticscholar   +1 more source

Quantitation of Human Immunodeficiency Virus Provirus and Circulating Virus: Relationship with Immunologic Parameters [PDF]

open access: yes, 2017
Virologic and seroimmunologic parameters were determined in 56 persons infected with human immunodeficiency virus (HIV). The provirus level varied from 10 to 100,000/106 CD4+ lymphocytes, and genomic HIV RNA was detectable in 39 of 56 patients at a ...
Chamot, E.   +3 more
core  

In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models.

open access: yesMolecular Therapy, 2017
Chaoran Yin   +14 more
semanticscholar   +1 more source

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