Results 251 to 260 of about 40,345 (282)

Longitudinal changes in the transcriptionally active and intact HIV reservoir after starting ART during acute infection. [PDF]

J Virol
Janssens J, Wedrychowski A, Kim SJ, Isbell C, Hoh R, Pillai SK, Henrich TJ, Deeks SG, Roan NR, Lee SA, Yukl SA.   +10 more
europepmc   +1 more source

BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription. [PDF]

Nat Commun
Pellaers E, Janssens J, Wils L, Denis A, Bhat A, Van Belle S, Feng D, Christ F, Zhan P, Debyser Z.   +9 more
europepmc   +1 more source

Differential HIV-1 Proviral Defects in Children vs. Adults on Antiretroviral Therapy. [PDF]

Viruses
Hasson JM, Katusiime MG, Capoferri AA, Bale MJ, Luke BT, Shao W, Cotton MF, van Zyl G, Patro SC, Kearney MF.   +9 more
europepmc   +1 more source

A simple phylogenetic approach to analyze hypermutated HIV proviruses reveals insights into their dynamics and persistence during antiretroviral therapy. [PDF]

Virus Evol
Shahid A, Jones BR, Duncan MC, MacLennan S, Dapp MJ, Kuniholm MH, Aouizerat B, Archin NM, Gange S, Ofotokun I, Fischl MA, Kassaye S, Goldstein H, Anastos K, Joy JB, Brumme ZL.   +15 more
europepmc   +1 more source

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A provirus put to work

Nature, 2000
Retroviruses incorporate themselves into a host genome in the form of a provirus, and can be passed on to the host's offspring. Evidence now emerges that one such provirus has been subverted to benefit of humans and other mammals that have a placenta — its protein product, called syncitin, may play an essential part in placental formation.
John M. Coffin, Jonathan P. Stoye
openaire   +2 more sources

Retroviruses as mutagens: Insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus

Cell, 1981
Integration of retroviral DNA appears to occur randomly in host genomes, suggesting that retroviruses can act as insertion mutagens. We have confirmed this prediction by showing that the nontransforming retrovirus, Moloney murine leukemia virus (M-MuLV), can insert its provirus within the selectable target provided by a single provirus in a clonal rat ...
Harold E. Varmus, Nancy Quintrell, Suzanne Ortiz   +2 more
openaire   +3 more sources

Structure of a Defective Provirus of Bovine Leukemia Virus

Microbiology and Immunology, 1987
AbstractDefective proviruses of bovine leukemia virus (BLV) in the genomes of infected cells were investigated by using Southern blotting hybridization analysis with various portions of a cloned BLV DNA as probes. When nine independent tumors of enzootic bovine leukosis with a single proviral copy per cell were examined, a single defective provirus of ...
Noriyuki Sagata, Hisao Izawa, Hiroyuki Koyama, Misao Onuma, Yasuki Ogawa, Yasuki Ogawa, Yoji Ikawa, Junko Tsuzuku-Kawamura   +7 more
openaire   +3 more sources

A physical map of caprine arthritis-encephalitis provirus

Virology, 1984
Terminally redundant linear proviral DNA of approximately 9.5 kb was the major unintegrated species recovered in the Hirt supernatant fraction of caprine synovial membrane cells infected with strain 75-G63 caprine arthritis-encephalitis virus. A physical map based on the cleavage sites of 13 restriction endonucleases was deduced for this proviral DNA.
William P. Cheevers, S.M. Roberson
openaire   +3 more sources

Virus, provirus et cancer

Revue d'histoire des sciences, 1994
RÉSUMÉ. — Nous nous proposons de retracer l'histoire du concept de prophage et de montrer son extension à celle du concept d'épisome et de provirus. Cette histoire se confond avec celle de la lysogénie, c'est-à-dire celle des relations d'un virus — à l'un de ses stades — à son hôte.
openaire   +4 more sources

The DNA Provirus Hypothesis

Science, 1976
I have discussed the observations and experiments that led to the formulation and establishment of the provirus hypothesis and the DNA provirus hypothesis, which includes RNA-directed DNA synthesis for the formation of the provirus. I have also discussed some aspects of the present status of our knowledge of the mechanism of formation of the ...
openaire   +3 more sources