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Structure of a Defective Provirus of Bovine Leukemia Virus
Microbiology and Immunology, 1987AbstractDefective proviruses of bovine leukemia virus (BLV) in the genomes of infected cells were investigated by using Southern blotting hybridization analysis with various portions of a cloned BLV DNA as probes. When nine independent tumors of enzootic bovine leukosis with a single proviral copy per cell were examined, a single defective provirus of ...
Y, Ogawa +6 more
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Attacking HIV Provirus: Therapeutic Strategies to Disrupt Persistent Infection
Infectious Disorders - Drug Targets, 2006The therapeutic armamentarium for human immunodeficiency virus type 1 (HIV-1) infection continues to expand. New targets such as entry and integration have recently been successfully exploited. However, HIV-infected patients in need of treatment are currently committed to lifelong suppressive therapy.
David M, Margolis, Nancy M, Archin
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Correlation between HIV provirus burden and in utero transmission
AIDS, 1993No predictive parameters of in utero or perinatal vertical transmission of HIV to newborns are known at present. Vertical transmission may be related to several biological parameters of maternal HIV infection: (1) immunological parameters (neutralizing antibodies); (2) the concentration of viral particles and/or infected cells; and (3) the selection of
P, Roques +9 more
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In vivo transfection of bovine leukemia provirus into sheep
Virology, 1992Bovine leukemia virus is horizontally transmitted mainly through infected cells by direct blood transfer. In this report, a cloned bovine leukemia virus (BLV) provirus was examined for its infectivity by direct inoculation into sheep. One hundred micrograms of plasmid DNA containing a complete provirus was mixed with a cationic liposome solution and ...
Willems, Luc +6 more
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Regulation of HIV-1 provirus transcription
2001Transcription of the HIV-genome is regulated by the interaction of viral long terminal repeat (LTR) cis-acting sequences with a complex of viral regulatory proteins and cellular transcription factors. The complex interplay between the cellular-, and/or viral proteins and LTR of different subtypes may play a role in the control of HIV-1 latency versus ...
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Revue d'histoire des sciences, 1994
Our purpose here is to retrace the history of the concept of prophage, to show how it expands into that of the episome and provirus. Its prehistory is that of lysogeny. We stress the relations between heredity and infection, the discovery of a non infectioius phase of the phage. André Lwoff is responsible for the concept of prophage.
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Our purpose here is to retrace the history of the concept of prophage, to show how it expands into that of the episome and provirus. Its prehistory is that of lysogeny. We stress the relations between heredity and infection, the discovery of a non infectioius phase of the phage. André Lwoff is responsible for the concept of prophage.
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Synthesis, Integration, and Transcription of the Retroviral Provirus
1983The RNA genome of a retrovirus is copied into DNA by the viral enzyme, RNA-dependent DNA polymerase, and the DNA copy of the retrovirus genome is inserted into one of the host’s chromosomes. This DNA copy, called a provirus, is transcribed into RNA by host enzymes, giving rise to both viral genomic RNA and viral messenger RNA.
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Not Beyond Reasonable Doubt: Howard Temin’s Provirus Hypothesis Revisited
Journal of the History of Biology, 2009During the 1960s, Howard M. Temin (1934-1994), dared to advocate a "heretical" hypothesis that appeared to be at variance with the central dogma of molecular biology, understood by many to imply that information transfer in nature occurred only from DNA to RNA. Temin's provirus hypothesis offered a simple explanation of both virus replication and viral-
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