Results 21 to 30 of about 66,750 (285)
Endogenous Retroviruses as Modulators of Innate Immunity
Pathogens, 2023 Endogenous retroviruses (ERVs), or LTR retrotransposons, are a class of transposable elements that are highly represented in mammalian genomes. Human ERVs (HERVs) make up roughly 8.3% of the genome and over the course of evolution, HERV elements ...
Eric Russ, Sergey Iordanskiy
doaj +1 more source
Microbiology Spectrum, 2023 In the search for control of human immunodeficiency virus type 1 (HIV-1) infection without antiretroviral therapy, posttreatment controllers (PTCs) are models of HIV remission.
Pauline Trémeaux +12 more
doaj +1 more source
mBio, 2023 Combination antiretroviral therapy (cART) suppresses viral replication but does not cure HIV infection because a reservoir of infectious (intact) HIV proviruses persists in long-lived CD4+T cells.
Johannes C. Botha +11 more
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The chromatin landscape at the HIV-1 provirus integration site determines viral expression
Nucleic Acids Research, 2020 HIV-1 persists lifelong in memory cells of the immune system as latent provirus that rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an HIV cure.
G. Vansant +6 more
semanticscholar +1 more source
The Impact of Cellular Proliferation on the HIV-1 Reservoir
Viruses, 2020 Human immunodeficiency virus (HIV) is a chronic infection that destroys the immune system in infected individuals. Although antiretroviral therapy is effective at preventing infection of new cells, it is not curative.
Maria C. Virgilio, Kathleen L. Collins
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The host genomic environment of the provirus determines the abundance of HTLV-1–infected T-cell clones [PDF]
Blood, 2011 Human T-lymphotropic virus type 1 (HTLV-1) persists by driving clonal proliferation of infected T lymphocytes. A high proviral load predisposes to HTLV-1–associated diseases.
Nicolas Gillet +9 more
openalex +2 more sources
Journal of Virus Eradication, 2022 Background and objectives: HIV-1 provirus integration in host genomes provides a lifelong reservoir of virally infected cells. Although not able to generate viral progeny, the expression of defective proviruses has been associated with activation ...
Gabriella Rozera +13 more
doaj +1 more source
HIV-1 transcription but not intact provirus levels are associated with systemic inflammation.
Journal of Infectious Diseases, 2020 HIV-1 infected individuals have increased inflammation, which has been associated with age-associated diseases. Plasma markers, cell-associated (ca) virus levels, and ability to stimulate RNA transcription in latently infected cell lines was examined in ...
A. Olson +4 more
semanticscholar +1 more source
Remnants of an ancient deltaretrovirus in the genomes of horseshoe aats (Rhinolophidae) [PDF]
, 2018 Endogenous retrovirus (ERV) sequences provide a rich source of information about the long-term interactions between retroviruses and their hosts. However, most ERVs are derived from a subset of retrovirus groups, while ERVs derived from certain other ...
Benda, Petr +7 more
core +5 more sources
Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9
Viruses, 2020 The major barrier to HIV-1 cure is the persistence of latent provirus, which is not eradicated by antiretroviral therapy. The “shock and kill” approach entails stimulating viral production with latency-reversing agents followed by the killing of cells ...
A. Olson +5 more
semanticscholar +1 more source