Results 21 to 30 of about 40,345 (282)

The First Genomic Analysis of Visna/Maedi Virus Isolates in China

Frontiers in Veterinary Science, 2022
Visna/Maedi virus (VMV) is a neglected pathogen that damages sheep and goats' nervous and respiratory systems. The virus was discovered 80 years ago and has been endemic in China for nearly four decades; nevertheless, there is little information ...
Jian-Yong Wu, Xiao-Yun Mi, Xue-Yun Yang, Jie Wei, Xiao-Xiao Meng, Hongduzi Bolati, Yu-Rong Wei   +6 more
doaj   +1 more source

Detection of HTLV-1 proviral DNA in cell-free DNA: Potential for non-invasive monitoring of Adult T cell leukaemia/lymphoma using liquid biopsy?

Frontiers in Immunology, 2023
IntroductionFragmented genomic DNA is constitutively released from dying cells into interstitial fluid in healthy tissue. In cancer, this so-called ‘cell-free’ DNA (cfDNA) released from dying malignant cells encodes cancer-associated mutations.
Thomas Joris, Thomas Joris, Jana Haddow, Graham P. Taylor, Graham P. Taylor, Lucy B. M. Cook, Lucy B. M. Cook, Lucy B. M. Cook, Lucy B. M. Cook, Aileen G. Rowan   +9 more
doaj   +1 more source

BET Inhibitor JQ1 Attenuates Feline Leukemia Virus DNA, Provirus, and Antigen Production in Domestic Cat Cell Lines

Viruses, 2023
Feline leukemia virus (FeLV) is a cosmopolitan gammaretrovirus that causes lifelong infections and fatal diseases, including leukemias, lymphomas, immunodeficiencies, and anemias, in domestic and wild felids.
Garrick M. Moll, Cheryl L. Swenson, Vilma Yuzbasiyan-Gurkan   +2 more
doaj   +1 more source

Single-Cell Imaging of HIV-1 Provirus (SCIP) [PDF]

Proceedings of the National Academy of Sciences, 2013
Recent advances in fluorescence microscopy provided tools for the investigation and the analysis of the viral replication steps in the cellular context. In the HIV field, the current visualization systems successfully achieve the fluorescent labeling of the viral envelope and proteins, but not the genome.
C. Di Primio, V. Quercioli, A. Allouch, R. Gijsbers, F. Christ, Z. Debyser, D. Arosio, A. Cereseto   +7 more
semanticscholar   +5 more sources

Remnants of an ancient deltaretrovirus in the genomes of horseshoe aats (Rhinolophidae) [PDF]

, 2018
Endogenous retrovirus (ERV) sequences provide a rich source of information about the long-term interactions between retroviruses and their hosts. However, most ERVs are derived from a subset of retrovirus groups, while ERVs derived from certain other ...
Benda, Petr, Elleder, Daniel, Farkašová, Helena, Gifford, Robert J., Görföl, Tamás, Hron, Tomáš, Hulva, Pavel, Pačes, Jan   +7 more
core   +9 more sources

Adeno-Associated Vector-Delivered CRISPR/SaCas9 System Reduces Feline Leukemia Virus Production In Vitro

Viruses, 2021
Feline leukemia virus (FeLV) is a retrovirus of cats worldwide. High viral loads are associated with progressive infection and the death of the host, due to FeLV-associated disease. In contrast, low viral loads, an effective immune response, and a better
A. Katrin Helfer-Hungerbuehler, Jimit Shah, Theres Meili, Eva Boenzli, Pengfei Li, Regina Hofmann-Lehmann   +5 more
doaj   +1 more source

In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control

Microbiology Spectrum, 2023
In the search for control of human immunodeficiency virus type 1 (HIV-1) infection without antiretroviral therapy, posttreatment controllers (PTCs) are models of HIV remission.
Pauline Trémeaux, Frédéric Lemoine, Adeline Mélard, Marine Gousset, Faroudy Boufassa, Sylvie Orr, Valérie Monceaux, Olivier Gascuel, Olivier Lambotte, Laurent Hocqueloux, Asier Saez-Cirion, Christine Rouzioux, Véronique Avettand-Fenoel   +12 more
doaj   +1 more source

Host sequences flanking the HIV provirus [PDF]

Nucleic Acids Research, 1990
A conserved property of retroviral proviruses is the presence of a direct repeat in the host DNA immediately flanking the viral sequence; each virus generates a repeat with a characteristic length. By sequencing the viral/host DNA junctions from five HIV-1 proviral clones, we have confirmed that integration of HIV results in the generation of a five ...
Deborah York-Higgins, Karen A. Vincent, Patrick O. Brown, Margarita Quiroga   +3 more
openaire   +3 more sources

The largest HIV-1-infected T cell clones in children on long-term combination antiretroviral therapy contain solo LTRs

mBio, 2023
Combination antiretroviral therapy (cART) suppresses viral replication but does not cure HIV infection because a reservoir of infectious (intact) HIV proviruses persists in long-lived CD4+T cells.
Johannes C. Botha, Dimiter Demirov, Carli Gordijn, Mary Grace Katusiime, Michael J. Bale, Xiaolin Wu, Daria Wells, Stephen H. Hughes, Mark F. Cotton, John W. Mellors, Mary F. Kearney, Gert U. van Zyl   +11 more
doaj   +1 more source

Sensitive HIV-1 DNA Pol Next-Generation Sequencing for the Characterisation of Archived Antiretroviral Drug Resistance

Viruses, 2023
Modern HIV-1 treatment effectively suppresses viral amplification in people living with HIV. However, the persistence of HIV-1 DNA as proviruses integrated into the human genome remains the main barrier to achieving a cure.
Johannes C. Botha, Matthew Byott, Moira J. Spyer, Paul R. Grant, Kathleen Gärtner, Wilson X. Chen, James Burton, Alasdair Bamford, Laura J. Waters, Carlo Giaquinto, Anna Turkova, Cindy L. Vavro, Eleni Nastouli   +12 more
doaj   +1 more source